{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T11:05:23Z","timestamp":1790161523231,"version":"4.1.0"},"reference-count":77,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T00:00:00Z","timestamp":1751587200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Since plant essential oil contains medicinally valuable compounds, its usability as a pharmacotherapeutic agent has been the focus of attention within the century's needs. The lack of sufficient studies on the medical and pharmacological evaluation of\n                    <jats:italic>Fibigia clypeata<\/jats:italic>\n                    (L.) Medik has made this plant the target of our study. This study analyzes the phytochemical composition and biological activity of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>F. clypeata<\/jats:italic>\n                    <\/jats:styled-content>\n                    essential oil. As a result, dimethyl disulfide and dimethyl trisulfide were found to be the main compounds of the plant essential oil, with rates of 73.13% and 19.87%, respectively. The antifungal property of plant essential oil is more effective than its antibacterial property, with MIC values ranging between 0.039 and 0.312\u2009\u03bcL\/mL for fungal species and up to 3.750\u2009\u03bcL\/mL for bacterial species. The enzyme inhibition profiles were investigated towards two enzymes, namely, anticholinesterase and \u03b1\u2010glucosidase, targeted for anti\u2010diabetic studies. Anticholinesterase activity was proved with the IC\n                    <jats:sub>50<\/jats:sub>\n                    values of 17.31 and 4.78\u2009\u03bcg\/mL for Acetylcholinesterase (AChE) and Butyrylcholinesterase (BChE) enzymes, respectively. DPPH and CUPRAC activities were the most promising antioxidant studies, with values of 1.54 and 3.72\u2009\u03bcg\/mL. It was observed that \u03b1\u2010Terpineol made a hydrogen bond with ASN80, and 1\u2010(2,6,6\u2010Trimethyl\u20101,3\u2010cyclohexadien\u20101\u2010yl)ethanol made a hydrogen bond with SER82. Although molecular dock scores were better for antifungal activity, it was determined that no interactions, such as hydrogen bonding or pi interaction, were observed. This preliminary study showed that\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>F. clypeata<\/jats:italic>\n                    <\/jats:styled-content>\n                    essential oil is a natural source with promising in\u00a0vitro antimicrobial, antioxidant, and anticholinesterase activities that warrants further investigation, including safety assessments, due to the high concentration of sulfur\u2010containing compounds. Molecular docking and ADME prediction results showed that \u03b1\u2010Terpineol and 1\u2010(2,6,6\u2010Trimethyl\u20101,3\u2010cyclohexadien\u20101\u2010yl)ethanol were more prone to antimicrobial activity.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.70493","type":"journal-article","created":{"date-parts":[[2025,7,5]],"date-time":"2025-07-05T02:03:48Z","timestamp":1751681028000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Shedding Light on the Phytochemical and Biological Fingerprints of\n                    <i>Fibigia clypeata<\/i>\n                    (L.) Medik Essential Oil as a Pharmacotherapeutic Agent"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8655-2716","authenticated-orcid":false,"given":"Tuba","family":"Unver","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Microbiology, Faculty of Pharmacy Inonu University  Malatya Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3909-0694","authenticated-orcid":false,"given":"Murat","family":"Bingul","sequence":"additional","affiliation":[{"name":"Department of Basic Pharmaceutical Sciences, Faculty of Pharmacy Dicle University  Diyarbak\u0131r Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8827-8557","authenticated-orcid":false,"given":"Harun","family":"Uslu","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy F\u0131rat University  Elaz\u0131\u011f Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7017-2447","authenticated-orcid":false,"given":"Ismet","family":"Gurhan","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Botany, Faculty of Pharmacy Inonu University  Malatya Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2345-7313","authenticated-orcid":false,"given":"Bunyamin","family":"Goktas","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy F\u0131rat University  Elaz\u0131\u011f Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8325-8116","authenticated-orcid":false,"given":"Hasan","family":"Sahin","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy Dicle University  Diyarbak\u0131r Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4163-9962","authenticated-orcid":false,"given":"Mehmet","family":"Boga","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Faculty of Pharmacy Dicle University  Diyarbak\u0131r Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2019.112466"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjbs.2018.05.007"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/10715760500210145"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.2955"},{"key":"e_1_2_10_6_1","first-page":"155","article-title":"Methode d'\u00e9tudes des propri\u00e9tes antiseptiques des huiles essentielles par contact direct en milieu gelose [Thymus capitatus, Rosmarinus officinalis, Eucalyptus globulus, Artemisia Herba Alba]","volume":"2","author":"Benjilali B.","year":"1986","journal-title":"Plantes M\u00e9dicinales et Phytoth\u00e9rapie"},{"key":"e_1_2_10_7_1","first-page":"3603","article-title":"Insecticidal Activity of Six Apiaceae Essential Oils Against Spodoptera Littoralis Biosduval (Lepidoptera: Noctuidae)","volume":"55","author":"Ben\u2010Khalifa N. 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