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Preclinical studies have extensively explored its impact on neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, and Huntington's disease, revealing its capacity to modulate key pathological processes. Mechanistically, BBR is shown to mitigate neuroinflammation, oxidative stress, and endoplasmic reticulum stress, thereby reducing neuronal damage and apoptosis. While these mechanistic insights and preclinical data are robust, clinical evidence remains nascent, necessitating further rigorous investigation to fully understand BBR's therapeutic efficacy and translate its promise into clinical practice. This narrative review provides a comprehensive examination of BBR's application in treating neurological conditions, emphasizing its molecular signaling pathways and critically evaluating the current translational landscape. It also identifies promising directions for future research into BBR's neuroprotective roles.<\/jats:p>","DOI":"10.1002\/fsn3.70563","type":"journal-article","created":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T06:49:23Z","timestamp":1754117363000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Beneficial Effects of Berberine on Brain Functions in Age\u2010Related Neurological Disorders: From Molecular Signaling to Treatment"],"prefix":"10.1002","volume":"13","author":[{"given":"Xiaolan","family":"Wang","sequence":"first","affiliation":[{"name":"Medical College Xijing University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiliang","family":"Hou","sequence":"additional","affiliation":[{"name":"Medical College Xijing University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, the Second Affiliated Hospital Xi'an Jiaotong University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, the Second Affiliated Hospital Xi'an Jiaotong University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4318-6320","authenticated-orcid":false,"given":"Melika","family":"Malek","sequence":"additional","affiliation":[{"name":"Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, the Second Affiliated Hospital Xi'an Jiaotong University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8]]},"reference":[{"key":"e_1_2_21_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0891988704267463"},{"key":"e_1_2_21_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-015-9652-6"},{"key":"e_1_2_21_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph15030281"},{"key":"e_1_2_21_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2003.02068.x"},{"key":"e_1_2_21_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharep.2015.03.002"},{"key":"e_1_2_21_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-021-00427-6"},{"key":"e_1_2_21_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.762654"},{"key":"e_1_2_21_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2019.03.024"},{"key":"e_1_2_21_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4274(02)00427-7"},{"key":"e_1_2_21_11_1","first-page":"53","article-title":"Neuroprotective Effect of Berberine Chloride on Cognitive Impairment and Hippocampal Damage in Experimental Model of Vascular Dementia","volume":"21","author":"Aski M. 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