{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:44:53Z","timestamp":1786977893830,"version":"build-2736575974"},"reference-count":45,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T00:00:00Z","timestamp":1751932800000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82474456"],"award-info":[{"award-number":["82474456"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Ulcerative colitis (UC) is a chronic inflammatory bowel disease in which dysbiosis of the intestinal flora plays a critical role in its pathogenesis.\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">Polygonum hydropiper<\/jats:styled-content>\n                      L\u2010Coptis chinensis Franch\n                    <\/jats:italic>\n                    (PH\u2010CC) known for its anti\u2010inflammatory properties and ability to regulate gut microbiota, has been demonstrated to alleviate UC. The aim of this study was to investigate the effects of PH\u2010CC on dysbiosis of intestinal flora and metabolic disorders in dextran sodium sulfate (DSS)\u2010induced UC mice. A UC mouse model was induced using a 3% DSS solution, and histopathological changes in the colon were assessed through hematoxylin and eosin staining. The composition and diversity of the intestinal flora were analyzed using 16S rDNA technology, whereas metabolomics was employed to identify potential differential metabolites and metabolic pathways through multivariate statistical analysis. Pearson correlation analysis was performed between metabolites, inflammatory factors, the NLRP3\/Caspase\u20101 pathway, and differential flora. The results revealed that treatment with PH\u2010CC improved the morphological structure of colon tissue and reduced damage in UC mice, while the model group exhibited significant damage to the crypt structure, exfoliation of the colonic mucosal epithelium, loss of glands, and infiltration of inflammatory cells. Analysis of 16S rDNA sequencing data indicated that PH\u2010CC regulated the DSS\u2010induced changes in gut microbiota, significantly decreasing the abundance of\n                    <jats:italic>norank_f_norank_o_Rhodospirillales, norank_f_UCG\u2010010, Corynebacterium, and Eubacterium_nodatum_group.<\/jats:italic>\n                    The differential microbiota exhibited a strong correlation with the NLRP3\/Caspase\u20101 pathway and downstream inflammatory factors. Additionally, 27 differential metabolites identified in fecal samples were primarily associated with phenylalanine metabolism and bile secretion, showing a high correlation with the differential microbiota. In conclusion, PH\u2010CC regulates dysbiosis in intestinal flora and metabolic disorders in UC mice by reducing the abundance of specific bacterial groups, thereby alleviating inflammatory damage to the colonic mucosa and improving the overall condition of UC.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.70584","type":"journal-article","created":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T07:54:33Z","timestamp":1751961273000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Herbal Pair\n                    <scp>\n                      <i>Polygonum hydropiper<\/i>\n                    <\/scp>\n                    <i>L\u2010Coptis chinensis Franch<\/i>\n                    Attenuate\n                    <scp>DSS<\/scp>\n                    \u2010Induced Ulcerative Colitis by Modulating Metabolism and Intestinal Flora"],"prefix":"10.1002","volume":"13","author":[{"given":"Feifei","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Pathology, The First Affiliated Hospital and School of Basic Medicine and Life Science Hainan Medical University  Haikou China"},{"name":"Engineering Research Center of Tropical Medicine Innovation and Transformation of Ministry of Education, International Joint Research Center of Human\u2010Machine Intelligent Collaborative for Tumor Precision Diagnosis and Treatment of Hainan Province, Hainan Provincial Key Laboratory of Research and Development on Tropical Herbs, School of Pharmacy Hainan Medical University  Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenhui","family":"Ren","sequence":"additional","affiliation":[{"name":"School of Life Sciences Hainan University  Haikou 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Herbs, School of Pharmacy Hainan Medical University  Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyu","family":"Mei","sequence":"additional","affiliation":[{"name":"Engineering Research Center of Tropical Medicine Innovation and Transformation of Ministry of Education, International Joint Research Center of Human\u2010Machine Intelligent Collaborative for Tumor Precision Diagnosis and Treatment of Hainan Province, Hainan Provincial Key Laboratory of Research and Development on Tropical Herbs, School of Pharmacy Hainan Medical University  Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Niu","sequence":"additional","affiliation":[{"name":"Department of Pathology, The First Affiliated Hospital and School of Basic Medicine and Life Science Hainan Medical University  Haikou 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