{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T04:25:49Z","timestamp":1793075149229,"version":"4.5.0"},"reference-count":57,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T00:00:00Z","timestamp":1752105600000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Liver fibrosis, closely linked to oxidative stress, remains a significant global health challenge. Fucoxanthin (Fx), a marine carotenoid extracted from brown algae, exhibits potent antioxidant properties, yet its molecular mechanism in liver fibrosis remains unclear. In the present study, a murine model of liver fibrosis was established through intraperitoneal injection of carbon tetrachloride (CCl\n                    <jats:sub>4<\/jats:sub>\n                    ) to investigate the therapeutic potential and underlying mechanisms of Fx. Histological staining and transmission electron microscopy were utilized to evaluate liver morphology, while assessments were conducted on hepatic function indicators, antioxidant indices, liver fibrosis markers, and inflammatory factors. Notably, treatment with Fx resulted in a significant improvement in serum liver function indicators compared to CCl\n                    <jats:sub>4<\/jats:sub>\n                    model mice. Furthermore, the levels of liver fibrosis markers and inflammatory factors were significantly decreased following Fx treatment. Moreover, Fx treatment led to a significant downregulation of hydroxyproline and alpha\u2010smooth muscle actin (\u03b1\u2010SMA) expression, while upregulating key antioxidative and ferroptosis\u2010related proteins. These proteins include nuclear factor erythroid 2\u2010related factor 2 (Nrf2), heme oxygenase\u20101 (HO\u20101), NAD(P)H:quinone oxidoreductase 1 (NQO1), glutamate\u2013cysteine ligase modifier (GCLM), glutathione peroxidase 4 (GPX4), solute carrier family 7 member 11 (SLC7A11), transferrin receptor 1 (TFR1), and ferritin light chain (FTL) protein expression, in comparison to the CCl\n                    <jats:sub>4<\/jats:sub>\n                    model mice. These findings suggest that Fx could effectively ameliorate liver fibrosis by mitigating CCl\n                    <jats:sub>4<\/jats:sub>\n                    \u2010induced oxidative stress and ferroptosis, highlighting its therapeutic potential in liver fibrosis management.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.70589","type":"journal-article","created":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T04:10:31Z","timestamp":1752207031000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Fucoxanthin Ameliorates Carbon Tetrachloride\u2010Induced Liver Fibrosis in Mice via Nrf2\/\n                    <scp>HO<\/scp>\n                    \u20101\/\n                    <scp>GPX4<\/scp>\n                    \u2010Mediated Ferroptosis Pathway"],"prefix":"10.1002","volume":"13","author":[{"given":"Zhongliang","family":"Liu","sequence":"first","affiliation":[{"name":"Zhoushan Hospital of Traditional Chinese 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