{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T16:00:58Z","timestamp":1785254458652,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T00:00:00Z","timestamp":1752105600000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Purslane, as a traditional edible and medicinal herb, has been proven to have good anti\u2010inflammatory activity. In this study, it was clarified that stearic acid was the main anti\u2010inflammatory substance in purslane and could decrease the secretion of inflammatory cytokines, tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1), interleukin\u20106 (IL\u20106), and interleukin\u201010 (IL\u201010) in lipopolysaccharide (LPS)\u2010stimulated RAW 264.7 cells. Meanwhile, the inhibitory effect of liposoluble extract of purslane (PLE) and stearic acid on LPS\u2010induced ulcerative enteritis was determined. LPS\u2010induced enteritis, including body weight loss, reduced weight of the small intestine, and histological intestinal damage, was significantly ameliorated in mice fed PLE and stearic acid. In particular, PLE could significantly reduce the levels of TNF\u2010\u03b1, IL\u20106, and interleukin\u20101\u03b2 (IL\u20101\u03b2) in the small intestine through NF\u2010\u03baB and MAPK signaling pathways. Thus, our results proved that purslane could be considered a natural anti\u2010inflammatory medicine to combat LPS\u2010induced inflammation and provide a theoretical basis for future applications in the field of medicine or functional food.<\/jats:p>","DOI":"10.1002\/fsn3.70596","type":"journal-article","created":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T04:30:02Z","timestamp":1752208202000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Anti\u2010Inflammatory Activity and Mechanism of Stearic Acid Extract From Purslane"],"prefix":"10.1002","volume":"13","author":[{"given":"Xiao\u2010Min","family":"Lin","sequence":"first","affiliation":[{"name":"Guangdong Provincial Key Lab of Biotechnology for Plant Development, School of Life Sciences South China Normal University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai\u2010Jing","family":"Chen","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Lab of Biotechnology for Plant Development, School of Life Sciences South China Normal University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui\u2010Min","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Food Science South China Agricultural University  Guangzhou China"},{"name":"Guozhen Health Technology (Beijing) Co. 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