{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T13:34:26Z","timestamp":1788960866896,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T00:00:00Z","timestamp":1753315200000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173944"],"award-info":[{"award-number":["82173944"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2021A1515011510"],"award-info":[{"award-number":["2021A1515011510"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Millettia speciosa<\/jats:italic>\n                    Champ. is a traditional medicinal and edible plant. Its aerial parts are often discarded, leading to resource waste. The aim of this study is to address the effective utilization of the aerial parts of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>M. speciosa<\/jats:italic>\n                    <\/jats:styled-content>\n                    and explore the potential mechanisms by which its active components improve metabolic disorders. HPLC\u2010Q\u2010TOF\u2010MS\/MS analysis identified a total of 41 chemical compounds in the stems, branches, and leaves of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>M. speciosa<\/jats:italic>\n                    <\/jats:styled-content>\n                    . Network pharmacology screening identified formononetin (FMN) as a key compound of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>M. speciosa<\/jats:italic>\n                    <\/jats:styled-content>\n                    . FMN could downregulate the expression of Iba\u20101 and GFAP in the hypothalamus of metabolic syndrome mice and alleviate neuronal damage in the hypothalamus. It may also improve glycolipid metabolism disorders by inhibiting the central NF\u2010\u03baB signaling pathway. In this study, we preliminarily demonstrated that the aerial parts of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>M. speciosa<\/jats:italic>\n                    <\/jats:styled-content>\n                    have significant medicinal value, providing theoretical guidance for the effective utilization of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>M. speciosa<\/jats:italic>\n                    <\/jats:styled-content>\n                    resources.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.70601","type":"journal-article","created":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T13:49:51Z","timestamp":1753364991000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Analysis of the Aerial Parts of\n                    <i>Millettia speciosa<\/i>\n                    Champ. and Mechanistic Study of Its Active Ingredient Formononetin in Improving Metabolic Syndrome"],"prefix":"10.1002","volume":"13","author":[{"given":"Wenjing","family":"Niu","sequence":"first","affiliation":[{"name":"Key Laboratory of Glucolipid Metabolic Diseases of the Ministry of Education, Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine Guangdong Pharmaceutical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruhai","family":"Jian","sequence":"additional","affiliation":[{"name":"Key Laboratory of Glucolipid Metabolic Diseases of the Ministry of Education, Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine Guangdong Pharmaceutical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lishen","family":"Zeng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Glucolipid Metabolic Diseases of the Ministry of Education, Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine Guangdong Pharmaceutical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyue","family":"Huang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Glucolipid Metabolic Diseases of the Ministry of Education, Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine Guangdong Pharmaceutical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9888-4331","authenticated-orcid":false,"given":"Jinyan","family":"Cai","sequence":"additional","affiliation":[{"name":"Key Laboratory of Glucolipid Metabolic Diseases of the Ministry of Education, Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine Guangdong Pharmaceutical University  Guangzhou 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