{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T12:04:51Z","timestamp":1791374691153,"version":"4.3.1"},"reference-count":38,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T00:00:00Z","timestamp":1752710400000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study aimed to optimize the ethanol extraction conditions of sun\u2010dried apricot (\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Prunus armeniaca<\/jats:italic>\n                    <\/jats:styled-content>\n                    L.) and evaluate the antioxidant capacity, phenolic, and flavonoid contents of the obtained extracts. Response surface methodology (RSM) was applied to determine the optimal extraction conditions, which were identified as 60\u00b0C temperature, 34% ultrasonic power, 46\u2009min sonication time, and a 4\u2009g\/mL solid\u2013liquid ratio. Under these conditions, the extract exhibited a total phenolic content (TPC) of 4.20\u2009mg GAE\/g, a total flavonoid content (TFC) of 7.09\u2009mg QE\/g, a DPPH (2,2\u2010diphenyl\u20101\u2010picrylhydrazyl) radical scavenging capacity of 1.37\u2009mg TE\/g, a ferric reducing antioxidant power (FRAP) value of 9.12\u2009mg TE\/g, and a thiobarbituric acid reactive substances (TBARS) level of 1.69\u2009mg MDA\/g. The artificial neural network (ANN) model provided highly accurate predictions for these parameters. Additionally, cell culture experiments demonstrated that the extract exerted a dose\u2010dependent cytotoxic effect on HCT116 colon cancer cells, significantly reducing their viability. These findings highlight the potential of sun\u2010dried apricot extracts as natural antioxidants with possible applications in the functional food and pharmaceutical industries.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.70610","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T12:09:03Z","timestamp":1752754143000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Optimization of Ethanol Extraction Conditions From Sun\u2010Dried Apricot and Prediction of Antioxidant, Phenolic, and Flavonoid Contents and Their Effects on\n                    <scp>HCT116<\/scp>\n                    Cells Using Artificial Neural Networks"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3715-8739","authenticated-orcid":false,"given":"K\u00fcbra","family":"Cinar Topcu","sequence":"first","affiliation":[{"name":"Ayd\u0131ntepe Vocational School, Department 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Sulusoglu","family":"Durul","sequence":"additional","affiliation":[{"name":"Agricultural Faculty, Department of Horticulture Kocaeli University  Kocaeli Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mizgin","family":"Ay","sequence":"additional","affiliation":[{"name":"Agricultural Faculty, Department of Horticulture Harran University  Sanliurfa Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Alyafei","sequence":"additional","affiliation":[{"name":"Department of Integrative Agriculture, College of Agriculture and Veterinary Medicine United Arab Emirates University  Al Ain UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8762-9693","authenticated-orcid":false,"given":"Faisal","family":"Hayat","sequence":"additional","affiliation":[{"name":"Department of Integrative Agriculture, College of Agriculture and Veterinary Medicine United Arab Emirates University  Al Ain 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