{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T16:00:56Z","timestamp":1785254456023,"version":"3.55.0"},"reference-count":49,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T00:00:00Z","timestamp":1752624000000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Cornus macrophylla<\/jats:italic>\n                    <\/jats:styled-content>\n                    Wall. Bark has been traditionally utilized for its therapeutic properties; however, limited scientific evidence is available that supports its role as having anti\u2010inflammatory and neuroprotective properties. Exploring the neuroprotective and anti\u2010inflammatory properties of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>C. macrophylla<\/jats:italic>\n                    <\/jats:styled-content>\n                    Wall. Bark may help in validating the therapeutic properties, presenting insights into its use as a potent natural component for modulating inflammation and oxidative stress\u2010related neurological ailments. In this study, crude extract along with different fractions of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>C. macrophylla<\/jats:italic>\n                    <\/jats:styled-content>\n                    Wall. Bark have been investigated for anti\u2010inflammatory and neuroprotective effects. In the in\u00a0vivo anti\u2010inflammatory assay, the ethyl acetate (EA) fraction showed activity of 68.3%, 79.7%, and 83.7% at dosages of 50, 100, and 200\u2009mg\/kg B.W. (Body weight) of all the mice decreased when treated with LPS while it increased when treated with aspirin, crude extract, dichloromethane (DCM), and EA, respectively. Rectal temperature increased when treated with lipopolysaccharide (LPS) and gradually decreased with aspirin, crude, DCM, and EA fraction. Moreover, locomotor activity was weak when treated with LPS and enhanced when treated with aspirin, crude, DCM, and EA, respectively. Neuroprotective ex\u00a0vivo results showed that the EA fraction decreased oxidative stress by restoring the glutathione (GSH) level by 21.10, 18.20, and 14.04\u2009\u03bcM\/mg proteins at doses of 100, 200, and 300\u2009mg\/kg body weight, respectively. The EA fraction decreased oxidative stress by restoring the superoxide dismutase (SOD) level by 0.17, 0.15, and 0.13\u2009units\/mg proteins at doses of 100, 200, and 300\u2009mg\/kg BW, respectively. The EA fraction decreased oxidative stress by restoring the malondialdehyde (MDA) level by 0.17, 0.15, and 0.13\u2009units\/mg proteins at dosages of 100, 200, and 300\u2009mg\/kg body weight, respectively. The EA fraction markedly increases the level of catalase (CAT) by 46.26, 41.12, and 39.37\u2009units\/mg proteins at doses of 100, 200, and 300\u2009mg\/kg body weight, respectively. In\u00a0vivo results validated the in\u00a0vitro results of different fractions of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>C. macrophylla<\/jats:italic>\n                    <\/jats:styled-content>\n                    .\n                  <\/jats:p>","DOI":"10.1002\/fsn3.70620","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T03:05:20Z","timestamp":1752721520000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Assessment of Preclinical Antioxidative and Anti\u2010Inflammatory Activities of\n                    <scp>\n                      <i>Cornus macrophylla<\/i>\n                    <\/scp>\n                    Wall. Bark"],"prefix":"10.1002","volume":"13","author":[{"given":"Ali","family":"Khan","sequence":"first","affiliation":[{"name":"Professional Institute of Health Sciences  Mardan KP Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aini","family":"Pervaiz","sequence":"additional","affiliation":[{"name":"Professional Institute of Health Sciences  Mardan KP Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Saeed","family":"Jan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Bacha Khan University  Charsadda KP Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bushra","family":"Ansari","sequence":"additional","affiliation":[{"name":"Professional Institute of Health Sciences  Mardan KP Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imad","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Professional Institute of Health Sciences  Mardan KP Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed Muhammad Mukarram","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of Swabi  Swabi KP Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdur","family":"Rauf","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Swabi  Khyber Pakhtunkhwa Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4674-9378","authenticated-orcid":false,"given":"Ahood","family":"Khalid","sequence":"additional","affiliation":[{"name":"University Institute of Diet and Nutritional Sciences, Allied Health Sciences The University of Lahore  Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3662-0933","authenticated-orcid":false,"given":"Anees Ahmed","family":"Khalil","sequence":"additional","affiliation":[{"name":"University Institute of Diet and Nutritional Sciences, Allied Health Sciences The University of Lahore  Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan A.","family":"Hemeg","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Sciences College of Applied Medical Sciences  Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yahya S.","family":"Al\u2010Awthan","sequence":"additional","affiliation":[{"name":"Department of Biology, Science University of Tabuk  Tabuk Saudi Arabia"},{"name":"Biodiversity Genomics Unit, Science University of Tabuk  Tabuk Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar S.","family":"Bahattab","sequence":"additional","affiliation":[{"name":"Department of Biology, Science University of Tabuk  Tabuk Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Mansour","family":"Quradha","sequence":"additional","affiliation":[{"name":"College of Education Seiyun University  Yemen"},{"name":"Pharmacy Department, Medical Sciences Aljanad University for Science and Technology  Taiz Yemen"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,16]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"121","volume-title":"Methods in Enzymology","author":"Aebi H.","year":"1984"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sajb.2022.01.018"},{"issue":"4","key":"e_1_2_10_4_1","article-title":"Protective Effect of Cornus mas Fruits Extract on Serum Biomarkers in CCl4\u2010Induced Hepatotoxicity in Male Rats","volume":"14","author":"Alavian S. 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