{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T16:00:59Z","timestamp":1785254459057,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T00:00:00Z","timestamp":1752624000000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS\u20102023\u201000220894"],"award-info":[{"award-number":["RS\u20102023\u201000220894"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Cancer cachexia is a complex syndrome involved in muscle wasting, fat depletion, fatigue, reduced appetite, and unintentional weight loss. Recent studies have suggested that natural products can prevent cancer cachexia; however, there have been no studies on the effects of\n                    <jats:italic>Litsea japonica<\/jats:italic>\n                    fruit extract on cancer cachexia. This study aimed to identify compounds of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>L. japonica<\/jats:italic>\n                    <\/jats:styled-content>\n                    fruit extracted from water (LJFE\u2010W) and those extracted from 30% ethanol (LJFE\u2010E) for cancer cachexia treatment. In\u00a0vitro and in\u00a0vivo models were used for C26 conditioned medium (CM)\u2010induced C2C12 myotubes and C26 tumor\u2010bearing mice. We demonstrated that LJFE\u2010W and LJFE\u2010E regulated myostatin (MSTN), E3 ligase muscle\u2010specific RING finger protein\u20101 (MuRF1), and muscular atrophy fbox\u20101 protein (MAFbx32) expression in a CM\u2010induced in\u00a0vitro model. LJFE\u2010E ameliorated conditioned medium\u2010induced myotube atrophy in cultured C2C12 myotubes. In contrast, LJFE\u2010W and LJFE\u2010E stimulated the Akt\u2013mTOR signaling pathway for protein synthesis in C2C12 myotubes. In animal models, the LJFE\u2010E\u2010injected C26 tumor\u2010bearing group showed lower transcript\u2010level expression of MSTN, MuRF1, and MAFbx32 in the gastrocnemius muscles than the C26 tumor\u2010bearing group. LJFE ameliorated muscle atrophy in the cancer cachexia model by inhibiting MSTN. Thus, LJFE can be used as a supplement to cancer cachexia therapy.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.70624","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T03:26:16Z","timestamp":1752722776000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Extract of\n                    <i>Litsea japonica<\/i>\n                    (Thunba.) Jussieu Fruit Reduces Muscle Atrophy in Cancer Cachexia"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-4759-0564","authenticated-orcid":false,"given":"Sang Woo","family":"Woo","sequence":"first","affiliation":[{"name":"Department of Anatomy Korea University College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooreum","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Anatomy Korea University College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihye","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Anatomy Korea University College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho Jin","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Anatomy Korea University College of Medicine  Seoul 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