{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T16:00:59Z","timestamp":1785254459017,"version":"3.55.0"},"reference-count":53,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T00:00:00Z","timestamp":1752624000000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100016692","name":"Key Research and Development Program of Ningxia","doi-asserted-by":"publisher","award":["2024BEG01006"],"award-info":[{"award-number":["2024BEG01006"]}],"id":[{"id":"10.13039\/100016692","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016692","name":"Key Research and Development Program of Ningxia","doi-asserted-by":"publisher","award":["2021BEG03100"],"award-info":[{"award-number":["2021BEG03100"]}],"id":[{"id":"10.13039\/100016692","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The escalating prevalence of alopecia, exacerbated by rising life stressors, significantly impacts individuals' physical appearance and psychological well\u2010being, highlighting the need for effective interventions. Black soybean (\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Glycine max<\/jats:italic>\n                    <\/jats:styled-content>\n                    [L.] Merr.) is widely used in medicinal and dietary fields with a high safety profile. This study investigated the effects and mechanisms of vinegar\u2010processed black soybean (VPBS) and its aqueous extract (VPBS\u2010AE) on hair regeneration and antialopecia in C57BL\/6J mice. For hair regeneration assessment, sodium sulfide\u2010depilated mice were orally administered VPBS (0.75, 1.5, or 3\u2009g\u00b7kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    \u00b7day\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) or VPBS\u2010AE (0.075, 0.15, or 0.3\u2009g\u00b7kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    \u00b7day\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) for 18\u2009days. Outcomes were evaluated via trichogram scoring, hair length and weight analysis, histomorphometric evaluation, and Western blot quantification of \u03b2\u2010catenin, GSK3\u03b2, and Wnt10b expression. To assess antialopecia effects, cyclophosphamide (100\u2009mg\u00b7kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) was intraperitoneally administered on Day 9 postdepilation, followed by 6\u2010day oral administration of VPBS (1.5, 3, or 6\u2009g\u00b7kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    \u00b7day\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) or VPBS\u2010AE (0.15, 0.3, or 0.6\u2009g\u00b7kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    \u00b7day\n                    <jats:sup>\u22121<\/jats:sup>\n                    ). Alopecia severity was determined through trichogram analysis and macroscopic scoring. Results demonstrated that VPBS dose\u2010dependently accelerated hair growth, stimulated anagen phase entry, and attenuated cyclophosphamide\u2010induced alopecia. VPBS\u2010AE similarly promoted follicular repair, delayed alopecia, and preserved follicle integrity. Western blotting analysis demonstrated that in the model group, sodium hydrosulfide\u2010induced alopecia led to significant downregulation of Wnt10b and \u03b2\u2010catenin, and upregulation of GSK\u20103\u03b2. While VPBS\u2010AE treatment effectively restored the expression levels of Wnt10b\/\u03b2\u2010catenin and suppressed GSK\u20103\u03b2 expression, suggesting the therapeutic effects of VPBS\u2010AE may be mediated through the Wnt\/\u03b2\u2010catenin pathway. Our findings substantiate VPBS and VPBS\u2010AE as promising functional food candidates for hair regeneration and alopecia prevention, with mechanistic insights implicating Wnt\/\u03b2\u2010catenin signaling modulation.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.70625","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T06:25:19Z","timestamp":1752733519000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Vinegar\u2010Processed Black Soybean Promotes Hair Growth and Prevents Alopecia via Wnt\/\u03b2\u2010Catenin Pathway"],"prefix":"10.1002","volume":"13","author":[{"given":"Yue","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Pharmacy Ningxia Medical University  Yinchuan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miaomiao","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Pharmacy Ningxia Medical University  Yinchuan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiasen","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmacy Ningxia Medical University  Yinchuan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenghao","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Pharmacy Ningxia Medical University  Yinchuan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingyuan","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Pharmacy Ningxia Medical University  Yinchuan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiling","family":"Wei","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences Ningxia Medical University  Yinchuan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxin","family":"He","sequence":"additional","affiliation":[{"name":"School of Pharmacy Ningxia Medical University  Yinchuan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Yao","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences Ningxia Medical University  Yinchuan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6813-3649","authenticated-orcid":false,"given":"Juan","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmacy Ningxia Medical University  Yinchuan People's Republic of China"},{"name":"Ningxia Engineering and Technology Research Center for Modernization of Characteristic Chinese Medicine, and Key Laboratory of Ningxia Ethnomedicine Modernization, Ministry of Education Ningxia Medical University  Yinchuan People's Republic 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