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This study evaluates the photoprotective, antioxidant, and anti\u2010inflammatory effects of aged\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Punica granatum<\/jats:italic>\n                    <\/jats:styled-content>\n                    extract (APEx), chosen for its richness in polyphenols, to assess its potential as a natural therapeutic agent in skin care. APEx was analyzed for its polyphenolic composition using high\u2010performance liquid chromatography coupled with mass spectrometry (HPLC\u2010MS). Its antioxidant capacity was measured via the Trolox Equivalent Antioxidant Capacity (TEAC) assay. Cellular studies on HaCaT keratinocytes and Caco\u20102 epithelial cells assessed the extract's antioxidant and anti\u2010inflammatory effects under stress conditions. A randomized, double\u2010blind, placebo\u2010controlled clinical trial involving 60 women evaluated APEx's impact on UV\u2010induced erythema, melanin content, skin hydration, and lightness. APEx demonstrated high antioxidant capacity (977.08\u2009\u00b1\u200915.73\u2009mmol Trolox\/100\u2009g) and significantly reduced reactive oxygen species and inflammatory cytokine levels in\u00a0vitro. Clinical findings showed significant reductions in UV\u2010induced erythema and melanin levels, with concurrent improvements in skin hydration and lightness compared to placebo. No adverse effects were reported during the trial. These findings highlight APEx as a safe and effective agent for mitigating UV\u2010induced skin damage, offering promising applications in dermatological and cosmetic formulations. Further studies are recommended to explore its molecular mechanisms and effectiveness across diverse populations.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.70631","type":"journal-article","created":{"date-parts":[[2025,8,3]],"date-time":"2025-08-03T11:38:27Z","timestamp":1754221107000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Photoprotective, Antioxidant and Anti\u2010Inflammatory Effects of Aged\n                    <i>Punica granatum<\/i>\n                    Extract: In\u00a0Vitro and In\u00a0Vivo Insights"],"prefix":"10.1002","volume":"13","author":[{"given":"Yuki","family":"Ikeda","sequence":"first","affiliation":[{"name":"Japanese Medical Institute  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mizuho","family":"Nasu","sequence":"additional","affiliation":[{"name":"Japanese Medical Institute  Tokyo 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Investigaci\u00f3n, Desarrollo e Innovaci\u00f3n en Biotecnolog\u00eda Sanitaria de Elche (IDiBE) Universidad Miguel Hern\u00e1ndez (UMH)  Elche Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Herranz\u2010L\u00f3pez","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n, Desarrollo e Innovaci\u00f3n en Biotecnolog\u00eda Sanitaria de Elche (IDiBE) Universidad Miguel Hern\u00e1ndez (UMH)  Elche Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicente","family":"Micol","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n, Desarrollo e Innovaci\u00f3n en Biotecnolog\u00eda Sanitaria de Elche (IDiBE) Universidad Miguel Hern\u00e1ndez (UMH)  Elche Spain"},{"name":"CIBEROBN (Physiopathology of Obesity and Nutrition CB12\/03\/30038) Carlos III Health Institute  Madrid 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