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Paracetamol (P) is a regularly used drug that is safe when used at therapeutic levels, but an overdose of it has the potential to cause nephron and hepato\u2010toxicity. Thereby, the effect of curcumin, which has anti\u2010oxidative properties, was tested on the hepato\u2010nephron toxicity caused by the overdose. This would prove the effective protection offered to curcumin, by native CN micelles. Male albino mice were treated with nano capsules for 4\u2009days (orally at 30\u2009mg\/kg of BW per day) before and after orally administering P (300\u2009mg\/kg of BW) for 2\u2009days. There were six groups, including preventive and curative (NE and pristine curcumin) and two control groups. The negative control mice were administered water only for 6\u2009days, and the other group was administered P at 300\u2009mg\/kg of BW, but no nano capsules\/curcumin were administered. BUN levels were observed to increase in NE powder treated groups in comparison to the P group. The creatinine, glutamate pyruvate transaminase, and alkaline phosphatase levels reduced in mice treated with NE powder after\/before P treatment. The levels of antioxidant indices like catalase, glutathione peroxidase, superoxide dismutase, and lipid peroxidation were noted in liver homogenate. The mice group treated with nano\u2010capsules orally showed increased activities of enzymes and a decrease in thio\u2010barbituric acid reactive substances as compared to the P group. Hence, nano capsules can act as a potential antioxidant that delivers curcumin with good bioavailability.<\/jats:p>","DOI":"10.1002\/fsn3.70648","type":"journal-article","created":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T08:57:26Z","timestamp":1758877046000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Curcumin Nanocapsules Prepared With Native Casein Micelles Exhibit Potential to Reduce Paracetamol\u2010Induced Oxidative Stress"],"prefix":"10.1002","volume":"13","author":[{"given":"Ankita","family":"Hooda","sequence":"first","affiliation":[{"name":"Department of Dairy Science and Food Technology Bananas Hindu University  Varanasi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bimlesh","family":"Mann","sequence":"additional","affiliation":[{"name":"EP and HS, Indian Council of Agricultural Research, ICAR  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6810-8216","authenticated-orcid":false,"given":"Abhishek Dutt","family":"Tripathi","sequence":"additional","affiliation":[{"name":"Department of Dairy Science and Food Technology Bananas Hindu University  Varanasi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nandita","family":"Das","sequence":"additional","affiliation":[{"name":"Food Safety and Standards Authority of India  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Himanshu Kumar","family":"Rai","sequence":"additional","affiliation":[{"name":"Department of Dairy Science and Food Technology Institute of Agricultural Sciences, Banaras Hindu University  Varanasi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sulaxana","family":"Singh","sequence":"additional","affiliation":[{"name":"Food Inspection Organization, Ministry of Defense, Government of India  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javed Masood","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Food Science and Nutrition King Saud University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8626-0617","authenticated-orcid":false,"given":"Aparna","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Department of Food Technology Lady Irwin College, University of Delhi  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dipendra","family":"Kumar Mahato","sequence":"additional","affiliation":[{"name":"CASS Food Research Centre School of Exercise and Nutrition Sciences, Deakin University  Burwood Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,26]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/15593258211033148"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2012\u20106080"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hfc.2011.08.003"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021\u20109258(19)51334\u20105"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2006.01.032"},{"issue":"6","key":"e_1_2_12_7_1","first-page":"873","article-title":"Tissue Antioxidant Status and Related Enzymes in Rats With Long\u2010Term Vitamin E Deficiency","volume":"22","author":"Chen L.","year":"1981","journal-title":"Nutrition Reports International"},{"issue":"5","key":"e_1_2_12_8_1","first-page":"361","article-title":"Rapid Determination of Urea Nitrogen in Serum or Plasma Without Deproteinization","volume":"33","author":"Crocker C. 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