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This study investigated the potential of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Setaria viridis<\/jats:italic>\n                    <\/jats:styled-content>\n                    (SV) supplementation for mitigating the impact of sarcopenic obesity on diet\u2010induced obese mice. Mice in the study were divided into groups and fed a normal diet, a high\u2010fat diet (HFD), or an HFD supplemented with 0.3% SV ethanol extract. After 16\u2009weeks, SV supplementation significantly reduced body weight gain and white adipose tissue mass, improved plasma lipid profiles, and preserved liver function without affecting food intake. Additionally, SV enhanced skeletal muscle mass and hind\u2010limb thickness, and restored anabolic signaling pathways such as IGF\u20101, PI3K\/Akt, and mTOR. Notably, SV supplementation activated AMP\u2010activated protein kinase (AMPK), accompanied by increased expression of SIRT1 and PGC\u20101\u03b1, leading to improved mitochondrial function and reduced intramuscular fat deposition. Mechanistically, 3D molecular docking simulations revealed that luteolin 7\u2010O\u2010glucoside, a SV\u2010derived flavonoid, binds to the AMPK ATP\u2010binding site with high affinity, providing structural insight into SV's AMPK\u2010activating potential. Furthermore, SV reduced levels of pro\u2010inflammatory cytokines (TNF\u2010\u03b1, IL\u20106) and enhanced antioxidant enzyme activity (GSH, GR, GPx), thereby alleviating oxidative stress and tissue fibrosis. These findings suggest that SV supplementation counters obesity\u2010induced muscle atrophy and metabolic dysfunction through flavonoid\u2010mediated AMPK activation, supporting its potential as a safe and effective nutritional strategy for managing sarcopenic obesity.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.70655","type":"journal-article","created":{"date-parts":[[2025,7,19]],"date-time":"2025-07-19T04:15:26Z","timestamp":1752898526000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["<scp>\n                      <i>Setaria viridis<\/i>\n                    <\/scp>\n                    Ethanol Extract Attenuates Muscle Loss and Body Fat Reduction in Sarcopenic Obesity by Regulating\n                    <scp>AMPK<\/scp>\n                    in High\u2010Fat Diet\u2010Induced Obese Mice"],"prefix":"10.1002","volume":"13","author":[{"given":"Eun\u2010Young","family":"Kwon","sequence":"first","affiliation":[{"name":"Department of Food Science and Nutrition Kyungpook National University  Daegu Republic of Korea"},{"name":"Center for Food and Nutritional Genomics Research Kyungpook National University  Daegu Republic of Korea"},{"name":"Center for Beautiful Aging Kyungpook National University  Daegu Republic of Korea"},{"name":"Department of Advanced Bioconvergence Kyungpook National University  Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u2010Won","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Food Science and Nutrition Kyungpook National University  Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u2010Young","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Food and Nutrition Chosun University  Gwangju Republic of Korea"},{"name":"Institute of Well\u2010Aging Medicare &amp; CSU G\u2010LAMP Project Group Chosun University  Gwangju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoungho","family":"Hwang","sequence":"additional","affiliation":[{"name":"Graduate School of Artificial Intelligence Kyungpook National University  Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1869-8842","authenticated-orcid":false,"given":"Youngji","family":"Han","sequence":"additional","affiliation":[{"name":"Bio\u2010Medical Research Institute Kyungpook National University Hospital  Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2013.08.001"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2009.06071.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnesp.2020.04.013"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocd.2015.04.013"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2013.03.072"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0229041"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-48382-5_9"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10600-014-0979-8"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-016-3874-y"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1101\/pdb.prot4986"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/10520293309116112"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201900982"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.17420111"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/nutrit\/nuz044"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.7570\/jomes23032"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2016.09.008"},{"issue":"1","key":"e_1_2_9_19_1","first-page":"47","article-title":"High\u2010Fat Diet\u2010Induced Oxidative Stress and Its Impact on Metabolic Syndrome: A Review","volume":"9","author":"Kesh S. 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