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Genistein, an isoflavone compound derived from leguminous plants, has pharmacological effects such as anti\u2010inflammatory, anti\u2010oxidation, anti\u2010bacteria, anti\u2010osteoporosis, anti\u2010tumor, and estrogen\u2010like effects. In recent years, genistein has shown broad application potential in the prevention and treatment of periodontitis due to its wide range of biological activities. Therefore, this review presents the mechanism of action of genistein in the prevention and treatment of periodontitis and the different delivery strategies of genistein, aiming to provide ideas for the basic research and clinical application of genistein in taking precautions against and curing the effect of periodontitis.<\/jats:p>","DOI":"10.1002\/fsn3.70657","type":"journal-article","created":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T07:00:14Z","timestamp":1754290814000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Genistein in the Prevention and Treatment of Periodontitis: A Review"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-7361-0709","authenticated-orcid":false,"given":"Yujun","family":"Lu","sequence":"first","affiliation":[{"name":"The Affiliated Stomatological Hospital of Guizhou Medical University Guizhou Medical University  Guiyang China"},{"name":"The 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