{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T11:08:48Z","timestamp":1788865728425,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T00:00:00Z","timestamp":1752796800000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002462","name":"Chungnam National University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002462","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Skeletal muscle health is crucial for maintaining physical function and metabolic homeostasis. This study investigated the effects of gallic acid, a naturally occurring phenolic compound, on myogenesis and muscle function. In\u00a0vitro experiments using mouse primary myoblasts demonstrated that gallic acid (10\u2009\u03bcg\/mL) enhanced myogenic differentiation, evidenced by increased Myh3 protein expression (3.3\u2010fold under growth conditions and 1.3\u2010fold under differentiation conditions) and enhanced myotube formation in both conditions. In\u00a0vivo studies were conducted using C57BL\/6N mice fed either a control diet or a 0.2% gallic acid\u2010supplemented diet for 8\u2009weeks. While gallic acid supplementation did not affect body weight, food intake, or general metabolic parameters, it significantly increased soleus muscle mass (10.56\u2009\u00b1\u20091.35\u2009mg vs. 8.28\u2009\u00b1\u20090.68\u2009mg in controls). Furthermore, gallic acid\u2010fed mice showed improved muscle function, with increased running distance (345.0\u2009\u00b1\u200928.8\u2009m vs. 262.2\u2009\u00b1\u200958.6\u2009m), extended time to exhaustion (24.2\u2009\u00b1\u20091.2\u2009min vs. 20.1\u2009\u00b1\u20093.0\u2009min), and enhanced grip strength (182.2\u2009\u00b1\u200919.4\u2009N vs. 157.3\u2009\u00b1\u200911.5\u2009N). These findings suggest that gallic acid could serve as a promising natural supplement for improving muscle function and exercise performance.<\/jats:p>","DOI":"10.1002\/fsn3.70667","type":"journal-article","created":{"date-parts":[[2025,7,19]],"date-time":"2025-07-19T04:29:16Z","timestamp":1752899356000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Gallic Acid Improves Muscular Function Through Enhanced Myoblast Myogenesis in Mice"],"prefix":"10.1002","volume":"13","author":[{"given":"Sangsoo","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Biochemistry College of Natural Sciences, Chungnam National University  Daejeon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong\u2010Yup","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Sports and Leisure Studies Daegu University  Gyeongsangbuk\u2010do Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1088-3383","authenticated-orcid":false,"given":"Kee K.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biochemistry College of Natural Sciences, Chungnam National University  Daejeon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,18]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.184507"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjbs.2021.09.060"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.5812\/ircmj.16424"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2020.2784"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.009358"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10020286"},{"key":"e_1_2_11_8_1","doi-asserted-by":"crossref","unstructured":"Conejo R. A. M.Valverde M.Benito andM.Lorenzo.2001. \u201cInsulin Produces Myogenesis in C2C12 Myoblasts by Induction of NF\u2010\u03baB and Downregulation of AP\u20101 Activities.\u201d186 no.1:82\u201394.https:\/\/doi.org\/10.1002\/1097\u20104652(200101)186:1.","DOI":"10.1002\/1097-4652(200101)186:1<82::AID-JCP1001>3.0.CO;2-R"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.7.4341"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2011.07.010"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.22289"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.090760"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2016.07.011"},{"key":"e_1_2_11_14_1","first-page":"48","article-title":"Acute and Chronic Oral Toxicity of Standardized Water Extract From the Fruit of Phyllanthus Emblica Linn","volume":"3","author":"Jaijoy K.","year":"2010","journal-title":"International Journal of Applied Research in Natural Products"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010018\u201027599\u20104"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2015"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.15567\/mljekarstvo.2014.0408"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.140.3573.1273"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20102006\u2010961535"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2019.152873"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00246.2003"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms221810023"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2017.09.016"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.068858"},{"key":"e_1_2_11_25_1","unstructured":"Orzechowski A. K.Grzelkowska W.Karlik andT.Motyl.2002.\u201cEffect of Quercetin and DMSO on Skeletal Myogenesis from C2C12 Skeletal Muscle Cells with Special Reference to PKB\/Akt Activity Myogenin and Bcl\u20102 Expression\u201d."},{"key":"e_1_2_11_26_1","first-page":"101","article-title":"Qualitative Analysis of Gallic Acid by HPLC Method in Different Extracts of Terminalia Bellerica Roxb. Fruit Qualitative Analysis of Gallic Acid by HPLC Method in Different Extracts of Terminalia Bellerica Roxb. Fruit","volume":"44","author":"Pal singh M.","year":"2019","journal-title":"Fabad Journal of Pharmaceutical Sciences"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.13208"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.4183\/aeb.2019.187"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.184507"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201027634\u20105"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12051479"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.117242"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967\u2010024\u201006042\u20105"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033\u2010023\u201008670\u20104"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2013.1632"}],"container-title":["Food Science &amp; Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/fsn3.70667","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/fsn3.70667","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/fsn3.70667","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T15:31:25Z","timestamp":1785252685000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/fsn3.70667"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":34,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1002\/fsn3.70667"],"URL":"https:\/\/doi.org\/10.1002\/fsn3.70667","archive":["Portico"],"relation":{},"ISSN":["2048-7177","2048-7177"],"issn-type":[{"value":"2048-7177","type":"print"},{"value":"2048-7177","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"2025-01-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70667"}}