{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T06:39:09Z","timestamp":1792478349071,"version":"4.5.0"},"reference-count":41,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T00:00:00Z","timestamp":1753228800000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Colocasia esculenta<\/jats:italic>\n                    <\/jats:styled-content>\n                    Linn., an annual herbaceous plant from the Araceae family, has long been utilized in traditional medicine throughout tropical and subtropical regions for the treatment of diverse health conditions. This research explored the impact of the methanolic extract derived from\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>C. esculenta<\/jats:italic>\n                    <\/jats:styled-content>\n                    flowers (CEF\u2010ME) on mice, examining various physiological, biochemical, hematological, and behavioral responses. Behavioral assessments for anxiolytic activity included the Elevated Plus Maze, Hole\u2010Board Test, and Light\u2013Dark Box Test. Sedative properties were evaluated using the Open\u2010Field Test and Hole\u2010Cross Test, while potential antidepressant effects were analyzed via the Tail\u2010Suspension Test and Forced\u2010Swimming Test. The administration of CEF\u2010ME led to observable changes in organ\u2010to\u2010body weight ratios, most notably a significant increase in liver size, which may indicate an upregulation of metabolic or detoxification functions. Biochemical tests revealed a hepatoprotective trend, characterized by decreased levels of ALT, ALP, bilirubin, cholesterol, and triglycerides. Yet, elevations in AST and creatinine at higher doses suggested potential hepatic and renal strain. Hematological profiles showed enhanced immune activity and red blood cell production, though the drop in platelet counts raised concern for thrombocytopenia. Behavioral evaluations revealed the extract's anxiolytic, sedative, and antidepressant properties, with effects comparable to diazepam and fluoxetine. The therapeutic potential of CEF\u2010ME was evident; however, its administration at high doses triggered toxicity concerns, particularly impacting the hepatic and renal systems. These observations highlight a pressing need for further studies to investigate its prolonged safety, pharmacological mechanisms, and optimal therapeutic range.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.70674","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T08:45:54Z","timestamp":1753260354000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Overdose Toxicological Effect of Methanol Extract of Popular Edible\n                    <scp>\n                      <i>Colocasia esculenta<\/i>\n                    <\/scp>\n                    Linn. Flowers: Biochemical, Hematological, and Behavioral Study on Swiss Albino Mice"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4169-899X","authenticated-orcid":false,"given":"Mahathir","family":"Mohammad","sequence":"first","affiliation":[{"name":"Department of Chemistry Chittagong University of Engineering &amp; Technology  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3473-5244","authenticated-orcid":false,"given":"Md. Tanvir","family":"Chowdhury","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Biological Sciences University of Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5372-1520","authenticated-orcid":false,"given":"Nazmul Hasan","family":"Eshaque","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Biological Sciences University of Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1926-6407","authenticated-orcid":false,"given":"Md. Jahirul Islam","family":"Mamun","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Biological Sciences University of Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayed Al Hossain","family":"Rabbi","sequence":"additional","affiliation":[{"name":"Department of Chemistry Government City College  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Amzad","family":"Hasan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of Science and Technology Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miton","family":"Chowdhury","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of Science and Technology Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md.","family":"Al\u2010mamun","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of Asia Pacific  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Jabir","family":"Rashid","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of Science and Technology Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7168-3257","authenticated-orcid":false,"given":"S. M. Moazzem","family":"Hossen","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Biological Sciences University of Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,23]]},"reference":[{"issue":"4","key":"e_1_2_11_2_1","first-page":"1","article-title":"Determination of Hematological Parameters and Biochemical Markers of Kidneys and Liver in the Acute Toxicity of Gomphrena celosioides Ethanol Extract","volume":"3","author":"Abou B.","year":"2015","journal-title":"European Journal of Biotechnology and Bioscience"},{"issue":"10","key":"e_1_2_11_3_1","first-page":"1386","article-title":"Treatment Related Hematologic Changes in a Population of Iranian Patients With Chronic Hepatitis C Infection From 2009 to 2014","volume":"46","author":"Ahmadinejad Z.","year":"2017","journal-title":"Iranian Journal of Public Health"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/FBP.0b013e328331b9bf"},{"issue":"10","key":"e_1_2_11_5_1","first-page":"1124","article-title":"A Comparative Study Between Atorvastatin and Pitavastatin Toxicity on Liver and Kidney in Albino Rats","volume":"11","author":"Al\u2010kareem Z. 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