{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T20:42:24Z","timestamp":1788295344835,"version":"build-2803163510"},"reference-count":59,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T00:00:00Z","timestamp":1753833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Indomethacin is a non\u2010steroidal anti\u2010inflammatory drug and may cause oxidative damage in the stomach tissue. Scientific studies are carried out to discover alternative bioactive phytocompounds and to reveal herbal products with pharmacological effects. In our study, we investigated whether the Ferula, which is antimicrobial and anti\u2010inflammatory, used for treatment of erectile dysfunction in men, menopausal disorders, diabetes, and prevention of osteoporosis, is effective in the treatment of gastric ulcer. 36 Sprague\u2013Dawley adolescent male rats were divided into six groups: indomethacin, indomethacin\u2009+\u2009Famotidine, indomethacin\u2009+\u2009Ferula 400\u2009mg, indomethacin\u2009+\u2009Ferula 800\u2009mg, Ferula 800\u2009mg, and healthy. It was determined that ulcerative areas were decreased in the high\u2010dose group of Ferula extract. SOD, GSH, and CAT levels increased with Ferula extract in 800\u2009mg doses, and MDA levels decreased with Ferula extract in 800\u2009mg doses compared to the indomethacin group.\n                    <jats:italic>TNF\u2010\u03b1<\/jats:italic>\n                    and\n                    <jats:italic>p53<\/jats:italic>\n                    gene expression levels were decreased in Ferula extract in low doses (600\u2009mg) compared to the indomethacin group. We determined that Ferula was effective in gastric ulcers.\n                    <jats:italic>Ferula orientalis<\/jats:italic>\n                    plant extract may be an alternative way to prevent drug\u2010induced gastric ulcer. This anti\u2010ulcer effect will be used as a food supplement in the future with further studies.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.70730","type":"journal-article","created":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T06:55:12Z","timestamp":1753944912000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Gastroprotective and Antioxidant Effects of Ferula Plant Extract Against Indomethacin Induced Gastric Ulcer in Rats"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5631-2335","authenticated-orcid":false,"given":"Serdar","family":"Yigit","sequence":"first","affiliation":[{"name":"Histology and Embryology Department Faculty of Medicine, Kafkas University  Kars Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3745-8173","authenticated-orcid":false,"given":"Fatma 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