{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:24:42Z","timestamp":1790717082214,"version":"4.1.0"},"reference-count":173,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Human physiology is a complex process encompassing various biochemical mechanisms, regulated by hundreds of chemical mediators, thus making it more complicated to understand. Balance between these mediators is mandatory to continue the helm of life; however, an imbalance can disrupt normal physiological functions and lead to chronic health conditions. Cancer is one such chronic state that occurs due to an imbalance or overproduction of reactive oxygen and nitrogen species (RONS), which are highly unstable and damage other chemical constituents in the body. The mutilation at the cellular level results in DNA and genetic mutation, uncontrolled cell proliferation, metastasis, organ dysfunction, and ultimately mortality. Various types of cancers are intimidating human life globally, and lung cancer is leading them all, followed by breast and colorectal cancer. Oxidative stress (OS) is the main root cause of cancers that occur due to overproduced RONS. Tumor suppressor genes (TSGs) like p53, PTEN, INK4, MADR2, APC, and oncogenes such as HER2, BCR\/ABL1, CMYC, EML4AK, RAS, WNT, ERK, and TRK get mutated by OS. Moreover, various pro\u2010inflammatory markers i.e., IL\u20101, IL\u20106, TNF\u2010\u03b1, IFN\u2010\u03b3, TGF\u2010\u03b2 and growth factors (VEGF, EGF, IGF\u20102) are also involved in cancer progression. Along with these aspects, the oncogenesis involves different signaling pathways\/axis such as MAPK, PI3K, mTOR, Wnt\/\u03b2\u2010catenin, GSK3, and NF\u2010\u03baB. Epigallocatechin gallate (EGCG), a bioactive compound abundantly existing in green tea and grapes with strong antioxidant activity and anticancer potential, is a suitable approach to reduce the cancer burden. The in\u00a0vitro and in\u00a0vivo anticancer studies of EGCG proved anticancer and anti\u2010tumor effects through modulation of cancer signaling pathways, reduction in cell proliferation, decreased metastasis, suppressed angiogenesis, enhanced antioxidant activity, inhibited pro\u2010inflammatory biomarkers, improved TSGs expression, and downregulated oncogenes expression. Shortly, the current review focuses on the anticancer potential of EGCG through possible mechanisms.<\/jats:p>","DOI":"10.1002\/fsn3.70735","type":"journal-article","created":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T10:57:01Z","timestamp":1754045821000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Anticancer Molecular Mechanisms of Epigallocatechin Gallate: An Updated Review on Clinical Trials"],"prefix":"10.1002","volume":"13","author":[{"given":"Ahmad Mujtaba","family":"Noman","sequence":"first","affiliation":[{"name":"Department of Human Nutrition, Faculty of Food Science and Nutrition Bahauddin Zakariya University  Multan Pakistan"},{"name":"TIMES Institute Multan  Multan Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Tauseef","family":"Sultan","sequence":"additional","affiliation":[{"name":"Department of Human Nutrition, Faculty of Food Science and Nutrition Bahauddin Zakariya University  Multan Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aimen","family":"Mazhar","sequence":"additional","affiliation":[{"name":"Department of Human Nutrition, Faculty of Food Science and Nutrition Bahauddin Zakariya University  Multan Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iqra","family":"Baig","sequence":"additional","affiliation":[{"name":"Department of Human Nutrition, Faculty of Food Science and Nutrition Bahauddin Zakariya University  Multan Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jawaria","family":"Javaid","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Health Promotion University of Home Economics  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6508-1962","authenticated-orcid":false,"given":"Muzzamal","family":"Hussain","sequence":"additional","affiliation":[{"name":"Department of Food Science Government College University Faisalabad  Faisalabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Imran","sequence":"additional","affiliation":[{"name":"Department of Food Science and Technology University of Narowal  Narowal Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suliman A.","family":"Alsagaby","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Sciences, College of Applied Medical Sciences Majmaah University  AL\u2010Majmaah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waleed","family":"Al Abdulmonem","sequence":"additional","affiliation":[{"name":"Department of Pathology, College of Medicine Qassim University  Buraidah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Mujtaba","sequence":"additional","affiliation":[{"name":"Department of Food Science and Technology, Faculty of Engineering Sciences and Technology Hamdard University Islamabad Campus  Islamabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9241-0266","authenticated-orcid":false,"given":"Tadesse Fenta","family":"Yehuala","sequence":"additional","affiliation":[{"name":"Faculty of Chemical and Food Engineering, Bahir Dar Institute of Technology Bahir Dar University  Bahir Dar City Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed M.","family":"Ghoneim","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, College of Pharmacy AlMaarefa University  Ad Diriyah Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ehab M.","family":"Mostafa","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, College of Pharmacy Jouf University  Sakaka Saudi Arabia"},{"name":"Pharmacognosy and Medicinal Plants Department, Faculty of Pharmacy (Boys) Al\u2010Azhar University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed A.","family":"Abdelgawad","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, College of Pharmacy Jouf University  Sakaka Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2020.05.011"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cryobiol.2020.09.010"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-14-1518"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2016.08.001"},{"issue":"5","key":"e_1_2_12_6_1","first-page":"908","article-title":"Colon Cancer: Risk Factors and Therapeutic Approaches","volume":"4","author":"Al\u2010Muswie R. T.","year":"2023","journal-title":"Central Asian Journal of Medical and Natural Science"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph21070954"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1515\/ntrev-2022-0013"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jksus.2023.102627"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/15376516.2013.879975"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm13091325"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu16050681"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.4103\/pm.pm_535_19"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24020368"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.2217\/nnm-2023-0342"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.2018.32.1_supplement.519.7"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23092346"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2019.03.010"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/15376516.2021.2021339"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-021-06413-2"},{"issue":"9","key":"e_1_2_12_21_1","first-page":"3222","article-title":"ER\u03b136 Is an Effective Target of Epigallocatechin\u20103\u2010Gallate in Hepatocellular Carcinoma","volume":"12","author":"Chen J.","year":"2019","journal-title":"International Journal of Clinical and Experimental Pathology"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2022.5309"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2016.3050"},{"issue":"2","key":"e_1_2_12_24_1","first-page":"105","article-title":"Pharmacokinetic and Chemoprevention Studies on Tea in Humans","volume":"64","author":"Chow H. H. S.","year":"2011","journal-title":"Pharmacological Research"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-017-1620-1"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1911310116"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1088\/2043-6254\/aad5c1"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2022.119357"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2019.103732"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2017.00110"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/jphp.12229"},{"issue":"5","key":"e_1_2_12_32_1","first-page":"186","article-title":"Ovarian, and Uterine Cancer: Etiology, Pathophysiology, and Management\u2010A Review","volume":"10","author":"David A.","year":"2020","journal-title":"International Journal of Life Sciences and Pharma Research"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.20473\/cdj.v11i1.2021.19-23"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/children9071083"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/21655979.2022.2051805"},{"key":"e_1_2_12_36_1","unstructured":"Dong ChaoQun D. C. L. F.Li Fang X. L.Xu Li et\u00a0al.2017.Inhibitory Effect of Epigallocatechin\u20103\u2010Gallate on Human Osteosarcoma Cell Line 143B and Its Underlying Mechanism."},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2017.4981"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-814774-0.00007-4"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/ans.15074"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2015.05.012"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euo.2021.09.006"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2013.12.034"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2019.00030"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2019.e02020"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-41752-8"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-018-0003-x"},{"issue":"14","key":"e_1_2_12_47_1","first-page":"4557","article-title":"Study of EGCG Induced Apoptosis in Lung Cancer Cells by Inhibiting PI3K\/Akt Signaling Pathway","volume":"22","author":"Gu J. J.","year":"2018","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1080\/21691401.2017.1423493"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.20643"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alcohol.2019.11.005"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.9"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2015.04.009"},{"issue":"3","key":"e_1_2_12_53_1","first-page":"1509","article-title":"Epigallocatechin\u20103\u2010Gallate Modulates Long Non\u2010Coding RNA and mRNA Expression Profiles in Lung Cancer Cells","volume":"19","author":"Hu D. L.","year":"2019","journal-title":"Molecular Medicine Reports"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v27.i27.4298"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X23500362"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.205224"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1159\/000515304"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom10111481"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpha.2023.09.005"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.5114\/wo.2017.70110"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.33371\/ijoc.v18i2.1211"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-021-08593-y"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.4103\/jcrt.JCRT_862_16"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7819-12-383"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.27117"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2012.972"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883911517710811"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.807632"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28135246"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2020.05.026"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2021.1878100"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2015.3802"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2014.00028"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10040797"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2016.0160"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.18858"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12094-020-02479-4"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.8b06665"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14153671"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2022.07.242"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep28479"},{"key":"e_1_2_12_82_1","first-page":"9868","article-title":"Inhibitory Effect of Epigallocatechin\u20103\u2010Gallate on Bladder Cancer Cells via Autophagy Pathway","volume":"9","author":"Liao H.","year":"2016","journal-title":"International Journal of Clinical and Experimental Medicine"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2020.112852"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2017-0388-CP"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-15959-6"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2018.10.019"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0217676"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2018.12.009"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14174200"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-020-07455-3"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118232"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241310737"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24081580"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/3480569"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.8b00242"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.31557\/apjcb.2019.4.4.71-74"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222111833"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.62347\/BMKT5441"},{"key":"e_1_2_12_99_1","doi-asserted-by":"crossref","unstructured":"Mohammadi R. Z.Fazeli A.Daraei andK.Asgari.2024.Suppression of Androgen Receptor and Activation of Apoptotic Signaling Pathway in the Prostate Cancer LNCaP Cells: The Synergistic Effect of Epigallocatechin\u20103\u2010Gallate and Conditioned Medium Derived From WJ\u2010MSCs.","DOI":"10.21203\/rs.3.rs-4250307\/v1"},{"key":"e_1_2_12_100_1","first-page":"612","article-title":"Epigallocatechin\u20103\u2010Gallate Enhances the Efficacy of MicroRNA\u201034a Mimic and MiR\u201093 Inhibitor Co\u2010Transfection in Prostate Cancer Cell Line","volume":"19","author":"Mokhtari H.","year":"2020","journal-title":"Iranian Journal of Allergy, Asthma and Immunology"},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11081566"},{"key":"e_1_2_12_102_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym13091375"},{"key":"e_1_2_12_103_1","doi-asserted-by":"publisher","DOI":"10.1590\/0001-3765202020200574"},{"key":"e_1_2_12_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2014.04.018"},{"key":"e_1_2_12_105_1","doi-asserted-by":"publisher","DOI":"10.1007\/s42452-024-05878-2"},{"key":"e_1_2_12_106_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-59281-z"},{"key":"e_1_2_12_107_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.00864"},{"key":"e_1_2_12_108_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.26900"},{"key":"e_1_2_12_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2020.117596"},{"key":"e_1_2_12_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2021.145774"},{"key":"e_1_2_12_111_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.2c03086"},{"key":"e_1_2_12_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemphyslip.2019.04.005"},{"key":"e_1_2_12_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smaim.2022.12.003"},{"key":"e_1_2_12_114_1","doi-asserted-by":"publisher","DOI":"10.3390\/nano14010047"},{"key":"e_1_2_12_115_1","doi-asserted-by":"publisher","DOI":"10.3390\/v14102138"},{"key":"e_1_2_12_116_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-019-04653-6"},{"key":"e_1_2_12_117_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232214008"},{"key":"e_1_2_12_118_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14010071"},{"key":"e_1_2_12_119_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/nxy316"},{"key":"e_1_2_12_120_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7RA10997K"},{"key":"e_1_2_12_121_1","article-title":"Effect of Sodium Butyrate and Epigallocatechin\u20103\u2010Gallate on the Genes Expression of Intrinsic Apoptotic Pathway on PA\u2010TU\u20108902, CFPAC\u20101, and CAPAN\u20101 Human Pancreatic Cancer Cell Lines: Epi\u2010Drugs and Intrinsic Apoptotic Pathway in Pancreatic Cancer","volume":"11","author":"Sanaei M.","year":"2022","journal-title":"Galen Medical Journal"},{"key":"e_1_2_12_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2018.01.022"},{"key":"e_1_2_12_123_1","doi-asserted-by":"publisher","DOI":"10.1159\/000354715"},{"key":"e_1_2_12_124_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2018.79.1905"},{"key":"e_1_2_12_125_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.17873"},{"key":"e_1_2_12_126_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-012-1448-y"},{"key":"e_1_2_12_127_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-017-0718-0"},{"key":"e_1_2_12_128_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/6175804"},{"key":"e_1_2_12_129_1","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-19-0383"},{"key":"e_1_2_12_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110246"},{"issue":"1","key":"e_1_2_12_131_1","first-page":"425","article-title":"(\u2212)\u2010Epigallocatechin\u20103\u2010Gallate Inhibits Bladder Cancer Stem Cells via Suppression of Sonic Hedgehog Pathway","volume":"42","author":"Sun X.","year":"2019","journal-title":"Oncology Reports"},{"key":"e_1_2_12_132_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf903375s"},{"key":"e_1_2_12_133_1","doi-asserted-by":"publisher","DOI":"10.1615\/JEnvironPatholToxicolOncol.2015011925"},{"issue":"10","key":"e_1_2_12_134_1","first-page":"1170","article-title":"Role and Mechanism Research on Reversal of 5\u2010Fluorouracil Resistance by Epigallocatechin Gallate in Gastric Cancer Drug\u2010Resistance Cells Lines SGC\u20107901\/5\u2010FU","volume":"19","author":"Tang H.","year":"2016","journal-title":"Chinese Journal of Gastrointestinal Surgery"},{"issue":"5","key":"e_1_2_12_135_1","first-page":"3873","article-title":"Epigallocatechin Gallate Induces Chemopreventive Effects on Rats With Diethylnitrosamine\u2010Induced Liver Cancer via Inhibition of Cell Division Cycle 25A","volume":"22","author":"Tang Y.","year":"2020","journal-title":"Molecular Medicine Reports"},{"key":"e_1_2_12_136_1","doi-asserted-by":"publisher","DOI":"10.5114\/wo.2021.103829"},{"key":"e_1_2_12_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2019.07.045"},{"key":"e_1_2_12_138_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-023-04428-6"},{"key":"e_1_2_12_139_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf900458e"},{"key":"e_1_2_12_140_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-023-03161-9"},{"key":"e_1_2_12_141_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2017.6010"},{"key":"e_1_2_12_142_1","doi-asserted-by":"publisher","DOI":"10.1158\/1538-7445.AM2017-162"},{"key":"e_1_2_12_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2017.09.054"},{"key":"e_1_2_12_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2015.06.033"},{"key":"e_1_2_12_145_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13102454"},{"key":"e_1_2_12_146_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v26.i17.2064"},{"key":"e_1_2_12_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2021.104570"},{"key":"e_1_2_12_148_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11081856"},{"key":"e_1_2_12_149_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8FO01397G"},{"key":"e_1_2_12_150_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12013-014-0428-0"},{"key":"e_1_2_12_151_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.15964"},{"key":"e_1_2_12_152_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-07728-1"},{"key":"e_1_2_12_153_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-023-10660-5"},{"key":"e_1_2_12_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfoodeng.2019.01.016"},{"key":"e_1_2_12_155_1","doi-asserted-by":"publisher","DOI":"10.31557\/APJCP.2021.22.4.1263"},{"key":"e_1_2_12_156_1","doi-asserted-by":"publisher","DOI":"10.1080\/09637486.2016.1198892"},{"key":"e_1_2_12_157_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2024.2384083"},{"key":"e_1_2_12_158_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-51331-3_2"},{"key":"e_1_2_12_159_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2019.1565490"},{"key":"e_1_2_12_160_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21020439"},{"key":"e_1_2_12_161_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfbc.13758"},{"key":"e_1_2_12_162_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2018.04.026"},{"key":"e_1_2_12_163_1","doi-asserted-by":"publisher","DOI":"10.1080\/21655979.2019.1657327"},{"key":"e_1_2_12_164_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43450-020-00079-5"},{"key":"e_1_2_12_165_1","doi-asserted-by":"publisher","DOI":"10.21147\/j.issn.1000-9604.2020.06.05"},{"key":"e_1_2_12_166_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-021-01522-6"},{"key":"e_1_2_12_167_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2014.1988"},{"key":"e_1_2_12_168_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2013.1446"},{"key":"e_1_2_12_169_1","doi-asserted-by":"crossref","unstructured":"Zhang Y. N. D.Yang F.Zhou et\u00a0al.2012.(\u2212)Epigallocatechin\u20103\u2010gallate induces non\u2010apoptotic cell death in human cancer cells via ROS\u2010mediated lysosomal membrane permeabilization.","DOI":"10.1371\/journal.pone.0046749"},{"key":"e_1_2_12_170_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-020-0741-x"},{"key":"e_1_2_12_171_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2017.563"},{"key":"e_1_2_12_172_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2020.165856"},{"key":"e_1_2_12_173_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.7990"},{"key":"e_1_2_12_174_1","first-page":"2910","article-title":"Expression and Clinical Significance of SOX9 and K\u2010Ras in Gastric Cancer","volume":"12","author":"Zhu X.","year":"2020","journal-title":"Chinese Journal of Primary Medicine and Pharmacy"}],"container-title":["Food Science &amp; Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/fsn3.70735","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T13:02:41Z","timestamp":1764766961000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/fsn3.70735"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":173,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1002\/fsn3.70735"],"URL":"https:\/\/doi.org\/10.1002\/fsn3.70735","archive":["Portico"],"relation":{},"ISSN":["2048-7177","2048-7177"],"issn-type":[{"value":"2048-7177","type":"print"},{"value":"2048-7177","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"2025-04-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70735"}}