{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T13:40:30Z","timestamp":1764769230764,"version":"3.46.0"},"reference-count":73,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T00:00:00Z","timestamp":1755043200000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    There are documented reports of 103 different\n                    <jats:italic>Crocus<\/jats:italic>\n                    species, commonly known as saffron, distributed across T\u00fcrkiye. Many of these species have been used not only as spices but also in the treatment or prevention of various diseases. However, the majority of research has focused only on\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Crocus sativus<\/jats:italic>\n                    <\/jats:styled-content>\n                    L., and only a few other members of the genus have been investigated for their chemical constituents and biological properties.\n                    <jats:italic>Crocus graveolens<\/jats:italic>\n                    Boiss. &amp; Reut. is one of those species used against gynecological diseases through oral administration. This is the first report regarding phytochemicals by LC\u2010HRMS analysis and in\u00a0vitro biological activities of the species. Accordingly, a total of 33 different secondary metabolites were detected in varying quantities. The major compound was determined as rutin (162.808\u2009\u00b1\u20094.5\u2009\u03bcg\/g extract). Total phenolic content (32.79\u2009\u00b1\u20091.30\u2009\u03bcg PEs\/mg extract) and total flavonoid content (40.29\u2009\u00b1\u20090.24\u2009\u03bcg QEs\/mg) were calculated. The antioxidant activity of the extract was evaluated by three different assays, namely, DPPH free and ABTS cation radical scavenging and CUPRAC activity methods, and moderate activity was demonstrated compared to the standards. The extract inhibited acetylcholinesterase with 30.88%\u2009\u00b1\u20091.51% and butyrylcholinesterase with 61.22%\u2009\u00b1\u20090.47% at a 200\u2009\u03bcg\/mL concentration. Besides, the extract was effective against\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    <\/jats:styled-content>\n                    ,\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Staphylococcus epidermidis<\/jats:italic>\n                    <\/jats:styled-content>\n                    , and\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Candida albicans<\/jats:italic>\n                    <\/jats:styled-content>\n                    strains. This study features a new contribution to\n                    <jats:italic>Crocus<\/jats:italic>\n                    research in T\u00fcrkiye.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.70751","type":"journal-article","created":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T11:46:13Z","timestamp":1755085573000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["First Insights Into the\n                    <scp>LC<\/scp>\n                    \u2010\n                    <scp>HRMS<\/scp>\n                    Profiling and Biological Activities of\n                    <i>Crocus graveolens<\/i>"],"prefix":"10.1002","volume":"13","author":[{"given":"Ezgi","family":"Ersoy","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy Faculty of Pharmacy, Biruni University  Istanbul T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"Bo\u011fa","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry Faculty of Pharmacy, Dicle University  Diyarbak\u0131r T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alevcan","family":"Kaplan","sequence":"additional","affiliation":[{"name":"Department of Crop and Animal Production Sason Vocational School, Batman University  Batman T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emel","family":"Matarac\u0131 Kara","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Microbiology Faculty of Pharmacy, Istanbul University  Istanbul T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serpil","family":"Demirci Kay\u0131ran","sequence":"additional","affiliation":[{"name":"Cukurova University Faculty of Pharmacy Pharmaceutical Botany Department  Adana T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1569-2535","authenticated-orcid":false,"given":"Esra","family":"Ero\u011flu \u00d6zkan","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy Istanbul University  Istanbul T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,13]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"11","article-title":"Phenolic Profiles, Antimicrobial and Antioxidant Activity of the Various Extracts of Crocus Species in Anatolia","volume":"4","author":"Acar G.","year":"2010","journal-title":"African Journal of Microbiology Research"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arabjc.2023.104705"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/catal13010063"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27113468"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12010\u2010009\u20108740\u20107"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072\u2010020\u201004427\u20100"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906\u2010020\u201003102\u20103"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sajb.2015.03.194"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1095\u20108339.1968.tb00094.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2021.113933"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5622"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.12.090"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/8214821"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11091650"},{"key":"e_1_2_8_16_1","unstructured":"Clinical and Laboratory Standards Institute.1997.\u201cReference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts (1997).\u201dApproved Standard\u2013Second Edition M27\u2010A2 Wayne PA 1997."},{"key":"e_1_2_8_17_1","unstructured":"Clinical and Laboratory Standards Institute.2006.\u201cMethods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically.\u201d7th Approved Standard M7\u2010A7. 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