{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T13:41:21Z","timestamp":1764769281270,"version":"3.46.0"},"reference-count":44,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T00:00:00Z","timestamp":1754524800000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["HF23C0048"],"award-info":[{"award-number":["HF23C0048"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Asthma is one of the chronic inflammatory disorders with shortness of breath, chest tightness, wheezing, and coughing. Considering that essential oils from aromatic plants have been widely used for relieving inflammatory diseases, the protective effects and molecular mechanisms of the inhalation of the essential oil formulation derived from\n                    <jats:italic>Mentha piperita<\/jats:italic>\n                    L.,\n                    <jats:italic>Asarum sieboldii<\/jats:italic>\n                    Miq., and\n                    <jats:italic>Abies holophylla<\/jats:italic>\n                    Maxim. named FEO\u201003 were investigated on asthma based on the network analysis and confirming in\u00a0vivo study. The target genes from consisting compounds of each essential oil were compared with the gene set of \u201cAsthma\u201d. Through network pharmacology analysis, the potential effects and target mechanisms of FEO\u201003 on asthma are closely associated with the T helper 2 (Th2)\u2010related cytokine interactions. And FEO\u201003 was aerosolized by nebulizer for 5\u2009min 3 times per week over 7\u2009weeks in the ovalbumin and particulate matter\u2010sensitized BALB\/c mice. Nebulized FEO\u201003 markedly reduced hyperplasia of respiratory epithelium and goblet cell activation in the trachea and lung. The number of inflammatory cells in BALF and serum immunoglobulin levels were significantly down\u2010regulated in the FEO\u2010treated mice. In addition, FEO\u201003 regulated expressions of Th2\u2010related cytokines with the periostin expressions. Furthermore, the fibrotic region of lung tissues was significantly decreased along with the cadherin switch markers by the FEO\u201003 treatment. Taken together, FEO\u201003, a formulation of essential oils, could ameliorate the fibrosis by inhibiting Th2\u2010specific cytokines and periostin derived epithelial\u2010mesenchymal transition in asthma.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.70763","type":"journal-article","created":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T10:06:22Z","timestamp":1754561182000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effectiveness of Inhalation of a New Essential Oil Formulation on Asthma Through Network Pharmacology and In\u00a0Vivo Analysis"],"prefix":"10.1002","volume":"13","author":[{"given":"Mi Hye","family":"Kim","sequence":"first","affiliation":[{"name":"College of Korean Medicine Woosuk University  Jeonju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong Chul","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Convergence Korean Medical Science, College of Korean Medicine Kyung Hee University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5308-2386","authenticated-orcid":false,"given":"Woong Mo","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Convergence Korean Medical Science, College of Korean Medicine Kyung Hee University  Seoul Republic of Korea"},{"name":"Korean Medicine Digital Convergence Center Kyung Hee University  Seoul Republic of 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