{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:09:30Z","timestamp":1790172570596,"version":"4.1.0"},"reference-count":71,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T00:00:00Z","timestamp":1757462400000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Nausea and vomiting are common and distressing responses to toxins, chemotherapy, and gastrointestinal disturbances. Although antiemetic medications are available, their adverse effects make safer substitutes necessary. In our study, Thymol (THY), a phenolic monoterpene from essential oils, was evaluated for its antiemetic potential using in\u00a0vivo and\n                    <jats:italic>in silico<\/jats:italic>\n                    methods. In the in\u00a0vivo study, emesis was induced in 2\u2010day\u2010old chicks by oral administration of copper sulfate pentahydrate (50\u2009mg\/kg). THY was administered orally at doses of 10, 20, and 40\u2009mg\/kg, alone or in combination with standard antiemetics ondansetron (ODN), domperidone (DPD), hyoscine butyl bromide (HYS), and promethazine hydrochloride (PRO). The 20\u2009mg\/kg dose (THY\u201020) showed the highest efficacy, significantly (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001) reducing the number of retches (24.6\u2009\u00b1\u20092.7; 67.2% reduction) and increasing latency to first retch (52.6\u2009\u00b1\u20094.2\u2009s; 77.18% increase) compared to the negative control (NC). The THY\u2009+\u2009ODN combination further enhanced effects (68.53% retch reduction). Molecular docking showed strong binding of THY to 5\u2010HT\n                    <jats:sub>3A<\/jats:sub>\n                    (\u22126.4\u2009kcal\/mol), D\n                    <jats:sub>2<\/jats:sub>\n                    (\u22127.1\u2009kcal\/mol), M\n                    <jats:sub>3<\/jats:sub>\n                    (\u22126.2\u2009kcal\/mol), and H\n                    <jats:sub>1<\/jats:sub>\n                    (\u22127.1\u2009kcal\/mol) receptors, comparable to standard drugs. Absorption, distribution, metabolism, excretion, and toxicity (ADMET) profiling revealed THY's compliance with Lipinski's Rule, high gastrointestinal absorption, blood\u2013brain barrier permeability, and low toxicity risk. The multi\u2010target binding profile and synergistic potential of THY suggest its promise as a natural, broad\u2010spectrum antiemetic. Further receptor\u2010specific studies and trials in chemotherapy\u2010induced emesis models are recommended to validate its clinical potential.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.70832","type":"journal-article","created":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T09:42:38Z","timestamp":1757497358000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Thymol as a Potential Natural Antiemetic: Insights From In\u00a0Vivo and In Silico Studies"],"prefix":"10.1002","volume":"13","author":[{"given":"Showkoth","family":"Akbor","sequence":"first","affiliation":[{"name":"Department of Pharmacy Gopalganj Science and Technology University  Gopalganj Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehedi Hasan","family":"Bappi","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Gopalganj Science and Technology University  Gopalganj Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah Al Shamsh","family":"Prottay","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Gopalganj Science and Technology University  Gopalganj Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farjanamul","family":"Haque","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Gopalganj Science and Technology University  Gopalganj Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayem","family":"Mia","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Gopalganj Science and Technology University  Gopalganj Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tawhida","family":"Islam","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Gopalganj Science and Technology University  Gopalganj Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zainab M.","family":"Almarhoon","sequence":"additional","affiliation":[{"name":"Department of Chemistry, College of Science King Saud University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eda S\u00f6nmez","family":"G\u00fcrer","sequence":"additional","affiliation":[{"name":"Sivas Cumhuriyet University, Faculty of Pharmacy Department of Pharmacognosy  Sivas Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William N.","family":"Setzer","sequence":"additional","affiliation":[{"name":"Aromatic Plant Research Center  Lehi Utah USA"},{"name":"Department of Chemistry University of Alabama in Huntsville  Huntsville Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7301-8151","authenticated-orcid":false,"given":"Javad","family":"Sharifi\u2010Rad","sequence":"additional","affiliation":[{"name":"Universidad Esp\u00edritu Santo  Samborond\u00f3n Ecuador"},{"name":"Centro de Estudios Tecnol\u00f3gicos y Universitarios del Golfo  Veracruz Mexico"},{"name":"Department of Medicine, College of Medicine Korea University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7560-4041","authenticated-orcid":false,"given":"Sakib","family":"Al Hasan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Gopalganj Science and Technology University  Gopalganj Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6392-3820","authenticated-orcid":false,"given":"Muhammad","family":"Torequl Islam","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Gopalganj Science and Technology University  Gopalganj Bangladesh"},{"name":"Bioinformatics and Drug Innovation Laboratory BioLuster Research Center Ltd.  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