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These compounds might play a role in alleviating \u03b2\u2010amyloid (A\u03b2)\u2010induced neurotoxicity. In this study, we investigated the effect of black raspberry in reducing A\u03b2 toxicity and improving mitochondrial function in the HT\u201022 cell model. HT\u201022 cells were co\u2010cultured together with black raspberry extract (BRE) and A\u03b2 and various markers for apoptosis and mitochondrial function were assessed. BRE treatment significantly improved cell viability, reduced reactive oxygen species (ROS) generation, and enhanced mitochondrial biogenesis via upregulation of PGC\u20101\u03b1 and Sirt1 expression. Among the isolated fractions, the ethanol fraction (Et\u2010F1) demonstrated the most potent neuroprotective effect. High\u2010performance liquid chromatography identified rutin as a major compound in Et\u2010F1, though it did not account for the full protective effect. In conclusion, our results suggest that BRE might be used as a natural supplementation for combatting A\u03b2\u2010associated dementia.<\/jats:p>","DOI":"10.1002\/fsn3.70840","type":"journal-article","created":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T04:29:27Z","timestamp":1757046567000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Neuroprotective Effects of Black Raspberry Extract Against \u03b2\u2010Amyloid\u2010Induced Cytotoxicity in\n                    <scp>HT<\/scp>\n                    \u201022 Cells"],"prefix":"10.1002","volume":"13","author":[{"given":"Yohanes","family":"Tandoro","sequence":"first","affiliation":[{"name":"Department of Nutrition Chung Shan Medical University  Taichung Taiwan"},{"name":"Faculty of Agricultural Technology Widya Mandala Catholic University Surabaya  Surabaya Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui\u2010Fang","family":"Chiu","sequence":"additional","affiliation":[{"name":"Department of Chinese Medicine Taichung Hospital Ministry of Health and Welfare  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You\u2010Cheng","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Health Industry Management Chung Shan Medical University  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sing\u2010Hua","family":"Tsou","sequence":"additional","affiliation":[{"name":"Department of Medical Research Chung Shan Medical University  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih\u2010Li","family":"Lin","sequence":"additional","affiliation":[{"name":"Institute of Medicine Chung Shan Medical University  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5371-7847","authenticated-orcid":false,"given":"Chin\u2010Kun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nutrition Chung Shan Medical University  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2020.00252"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28145415"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.02.001"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj20021619"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05354"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9061339"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq160"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fenvs.2014.00053"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom13030549"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21072564"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673\u20105374.139483"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics10070845"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.72.121801.161629"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf1023388"},{"key":"e_1_2_9_16_1","unstructured":"Johnson J. 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