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Natural cocoa, rich in polyphenols, influences neuroplasticity and cognitive processes. This study examined the effects of a high\u2010phenolic cocoa\u2010enriched diet on mice previously exposed to cocaine in a conditioned place preference (CPP) paradigm, assessing CPP maintenance, cognitive and emotional behavior, and adult hippocampal neurogenesis (AHN) after protracted abstinence. Forty\u2010two male and female C57BL\/6JRj mice were divided into saline (VEH) and cocaine (COC) groups. The CPP paradigm included pre\u2010conditioning, 2\u2009weeks of conditioning with alternating cocaine (20\u2009mg\/kg) and saline pairings, and a post\u2010conditioning test. COC mice then received either a 10% cocoa\u2010enriched diet or regular diet. After 24\u2009days, mice underwent a second CPP test session and a cocaine\u2010induced reinstatement session (10\u2009mg\/kg). Behavioral assessments and immunohistochemistry for AHN\u2010related markers followed. While cocaine did not produce long\u2010term emotional and cognitive changes, it reduced the survival of adult\u2010born cells differentiating into mature neurons. Cocoa consumption did not influence the long\u2010term CPP maintenance but significantly increased cocaine\u2010induced reinstatement and heightened subsequent anxiety\u2010like behavior in the COC mice. Additionally, cocoa\u2010fed mice showed enhanced AHN; however, mediation analysis confirmed that neurogenesis did not influence drug\u2010seeking. No sex differences were observed. These findings suggest that a cocoa\u2010rich diet may modulate addiction\u2010related behavior through pathways independent of AHN. Although cognitive, emotional, and neuroprotective benefits are associated with cocoa consumption, its role in cocaine addiction requires further investigation, as there is a potential risk of cocoa interacting with drug reward or drug\u2010seeking.<\/jats:p>","DOI":"10.1002\/fsn3.70842","type":"journal-article","created":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T06:52:27Z","timestamp":1757919147000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["High\u2010Phenolic Cocoa Enhances Drug\u2010Induced Reinstatement of Cocaine\u2010Conditioned Place Preference Independently of Increasing Adult Hippocampal Neurogenesis"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6335-2685","authenticated-orcid":false,"given":"Sonia","family":"Melgar\u2010Locatelli","sequence":"first","affiliation":[{"name":"Departamento de Psicobiolog\u00eda y Metodolog\u00eda de las Ciencias del 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