{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:07:57Z","timestamp":1790172477006,"version":"4.1.0"},"reference-count":53,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T00:00:00Z","timestamp":1756857600000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>As a dual\u2010purpose medicinal and edible resource, Perilla seeds are rich in bioactive compounds. There are very few studies on the by\u2010product of perilla seed hells. Moreover, there is a lack of systematic research on the chemical composition and biological activity of perilla seed hell polyphenols. We employed ultrasound\u2010assisted extraction (60% ethanol, 410\u2009W power, 30\u2009min, liquid\u2013solid ratio 30:1\u2009mL\/g) to obtain polyphenols from PSH, yielding perilla seed hulls polyphenol crude extraction (PSH\u2010C), and further verified the presence of polyphenolic compounds using Fourier transform infrared spectroscopy (FT\u2010IR). Subsequently, PSH\u2010C was further separated and purified using HPD600 macroporous resin to obtain a purified perilla seed hulls polyphenol extract (PSH\u2010P). The polyphenolic composition of PSH\u2010P was characterized by UPLC\u2010MS\/MS, and the major polyphenols were quantitatively analyzed using authentic standards. Antioxidant assays demonstrated that PSH\u2010P could effectively scavenge free radicals. PSH\u2010P significantly inhibited nitric oxide (NO) production, suppressed the production of inflammatory factors, and downregulated the transcription of iNOS and COX\u20102. PSH\u2010P likely exerts anti\u2010inflammatory effects by suppressing LPS\u2010induced nuclear translocation of NF\u2010\u03baB (p65) and inhibiting the expression of P\u2010p65 and P\u2010I\u03baB\u03b1, thereby blocking NF\u2010\u03baB signaling pathway activation. PSH\u2010P likely exerts its anti\u2010inflammatory effects by blocking NF\u2010\u03baB pathway activation through suppression of LPS\u2010induced nuclear translocation of p65 and inhibition of P\u2010p65 and P\u2010I\u03baB\u03b1 expression.<\/jats:p>","DOI":"10.1002\/fsn3.70847","type":"journal-article","created":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T12:00:42Z","timestamp":1756900842000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Perilla Seed Hulls Polyphenol Extract: Molecular Characterization and Suppression of\n                    <scp>LPS<\/scp>\n                    \u2010Induced Inflammation in\n                    <scp>RAW<\/scp>\n                    264.7 Cells via\n                    <scp>NF<\/scp>\n                    \u2010\n                    <scp>\u03baB<\/scp>\n                    Signaling Pathway"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-2002-1343","authenticated-orcid":false,"given":"Di","family":"Xie","sequence":"first","affiliation":[{"name":"College of Food Science and Engineering Jilin Agricultural University  Changchun China"},{"name":"College of Chemistry Baicheng Normal University  Baicheng China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingcong","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine Baicheng Medical College  Baicheng China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanrong","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering Jilin Agricultural University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinlu","family":"Gao","sequence":"additional","affiliation":[{"name":"School of Biological and Food Engineering Jilin Engineering Normal University  Changchun China"},{"name":"Jilin Provincial Collaborative Innovation Center for Coarse Cereals Resources Development and Industrialization Jilin Engineering Normal University  Changchun China"},{"name":"Jilin\u2010Xinjiang Joint Laboratory for Scientific and Technological Innovation in Medicine\u2010Food Homology Industry Jilin Engineering Normal University  Changchun 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