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Although medication is still the mainstay of managing SLE, tailored nutrition provides a mechanistically sound way to reduce inflammation and promote immunological balance. The present article links certain nutritional factors to pathways controlling cytokine equilibrium, oxidative damage, endothelium integrity, and regulatory T cell activity. These elements include unsaturated fats, vitamins, polyphenols, probiotics, and fiber\u2010derived short\u2010chain fatty acids (SCFAs). Additionally, it assesses microbiome\u2010based therapies and looks at nutritional habits that may have anti\u2010inflammatory properties, such as the Mediterranean style of eating. Based on these findings, we suggest an evidence\u2010based \u201canti\u2010lupus plate\u201d approach that takes into consideration renal function, concurrent medical conditions, and drug\u2013nutrient relationships while matching dietary habits to pathophysiological goals. Research limitations are highlighted as major obstacles, especially the lack of broad, biomarker\u2010driven research. These shortfalls must be filled in order to integrate food into a research\u2010based SLE treatment. Regulated procedures, extended follow\u2010up, and multimodal dietary treatments are necessary to achieve this.<\/jats:p>","DOI":"10.1002\/fsn3.70890","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T07:41:20Z","timestamp":1756712480000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Anti\u2010Lupus Plate: Mapping Nutritional Interventions to Inflammatory Pathways in Systemic Lupus Erythematosus"],"prefix":"10.1002","volume":"13","author":[{"given":"Xiaowei","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Rheumatology, the First Affiliated Hospital Inner Mongolia Medical University  Hohhot China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0943-6129","authenticated-orcid":false,"given":"Guoliang","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Physics, School of Physical Science and Technology Inner Mongolia University  Hohhot China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,1]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"crossref","unstructured":"Abrishamkar H. 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