{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T13:06:59Z","timestamp":1790168819096,"version":"4.1.0"},"reference-count":59,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T00:00:00Z","timestamp":1763683200000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Diabetes, a metabolic disease characterized by high blood sugar, causes damage to many organs in the body. Accordingly, the present study investigates the effects of silver nanoparticle\u2010loaded 18\u03b2\u2010glycyrrhetinic acid (AgNP+18\u03b2\u2010GA) on P2X7 receptor and ER stress\u2010mediated NLRP3 inflammasome activation in testicular tissue. 42 Wistar\u2010Albino rats aged 6\u2009months were used. The rats were divided into the following seven groups: Control, AgNP+18\u03b2\u2010GA100, DM, DM\u201018\u03b2\u2010GA100, DM\u2010AgNP+18\u03b2\u2010GA50, DM\u2010AgNP+18\u03b2\u2010GA100, and DM\u2010AgNP. After the experiment, sperm samples obtained from the rats were evaluated. Oxidative stress markers, serum IL\u20101\u03b2, and TNF\u2010\u03b1 levels were determined in the testicular tissue samples taken separately. In addition, Caspase\u20101, NLRP3, P2X7, Caspase\u20103, NF\u2010\u03baB, IRE1, ATF6, and CHOP protein expression levels were evaluated using Western blot analysis of histopathological examinations. Specifically, the most significant decrease was observed in NLRP3, Caspase\u20101, P2X7, and NF\u2010\u03baB levels in the DM\u2010AgNP+18\u03b2\u2010GA100 group (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). About sperm parameters, while sperm motility and viability significantly decreased in diabetic groups (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05), a significant improvement in these values was observed in the AgNP+18\u03b2\u2010GA applied groups (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). AgNP+18\u03b2\u2010GA improved sperm morphology and histopathological damage in diabetes\u2010induced testicular damage, as well as inhibited P2X7 receptor and endoplasmic reticulum stress\u2010mediated NLRP3 inflammasome activation.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.70893","type":"journal-article","created":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T06:21:57Z","timestamp":1763792517000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effects of Silver Nanoparticle\u2010Loaded 18\u03b2\u2010Glycyrrhetinic Acid on P2X7 Receptor and Endoplasmic Reticulum Stress\u2010Mediated NLRP3 Inflammasome Activation in Testicular Tissue in an Animal Diabetes Model"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5091-1262","authenticated-orcid":false,"given":"Volkan","family":"Gelen","sequence":"first","affiliation":[{"name":"Department of Physiology, Faculty of 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