{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:08:23Z","timestamp":1790172503905,"version":"4.1.0"},"reference-count":161,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T00:00:00Z","timestamp":1757203200000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Date fruit (\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Phoenix dactylifera<\/jats:italic>\n                    <\/jats:styled-content>\n                    L.) is a highly nutritious and therapeutic food with substantial potential to improve human health. This review emphasizes the nutritional and therapeutic traits of date fruit, focusing on its role as a functional food and dietary supplement. Rich in essential nutrients, antioxidants, and bioactive moieties, date fruit has been shown to provide numerous health benefits. These include managing metabolic disorders such as dyslipidemia, hyperglycemia, liver toxicity, kidney toxicity, obesity, and cardiovascular diseases. Studies exhibit that regular date consumption can contribute to the prevention of chronic illnesses and promote overall health and well\u2010being. However, while research on individual bioactive compounds has been extensive, the full biological effects of the fruit, particularly in synergistic contexts, are not yet fully understood. This review consolidates and critically evaluates recent in\u00a0vitro, in\u00a0vivo, and clinical findings on date fruit's bioactive substances, particularly flavonoids, phenolic acids, and dietary fiber, and their role in modulating metabolic disease. Unlike previous studies, this review highlights the specific models and effective dosages: for example, animal studies using 300\u20131000\u2009mg\/kg\/day of date extracts showed improvements in lipid profiles and antioxidant enzyme activity (SOD, CAT, GST), while in\u00a0vitro assays at 60\u2013600\u2009\u03bcg\/mL demonstrated anti\u2010inflammatory and anti\u2010apoptotic mechanisms via NF\u2010\u03baB inhibition and cytokine downregulation (IL\u20106, COX\u20102, TNF\u2010\u03b1). Furthermore, HPLC\u2010ESI\u2010MS profiling showed cultivar\u2010specific differences in polyphenol content and antioxidant potential. The paper also explores lesser\u2010studied effects such as neuroprotection, immunomodulation, and antitumor activity. By integrating dosage\u2010specific mechanistic insights and model\u2010based outcomes, this review offers a more targeted framework for developing functional foods and nutraceuticals from date fruit and highlights the urgent need for further clinical trials to validate these findings and optimize therapeutic applications.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.70896","type":"journal-article","created":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T05:21:50Z","timestamp":1757308910000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Therapeutic Power of Date Fruit (\n                    <i>Phoenix dactylifera<\/i>\n                    L.): A Nutrient\u2010Rich Superfood for Holistic Health and Disease Prevention"],"prefix":"10.1002","volume":"13","author":[{"given":"Kanza Aziz","family":"Awan","sequence":"first","affiliation":[{"name":"Department of Food and Nutritional Sciences, Faculty of Science and Technology University of Central Punjab  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9521-1158","authenticated-orcid":false,"given":"Sanabil","family":"Yaqoob","sequence":"additional","affiliation":[{"name":"Department of Food and Nutritional Sciences, Faculty of Science and Technology University of Central Punjab  Lahore Pakistan"},{"name":"Panvascular Diseases Research Center, Quzhou People's Hospital The Quzhou Affiliated Hospital of Wenzhou Medical University  Quzhou China"},{"name":"Laboratory of Food Nutrition and Clinical Research, Institute of Seafood Zhejiang Gongshang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iahtisham","family":"Ul\u2010Haq","sequence":"additional","affiliation":[{"name":"Kauser Abdulla Malik School of Life Sciences Forman Christian College (A Chartered University)  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiba","family":"Naveed","sequence":"additional","affiliation":[{"name":"Department of Food and Nutritional Sciences, Faculty of Science and Technology University of Central Punjab  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aysha","family":"Imtiaz","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering Yangzhou University  Yangzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amal","family":"Shaukat","sequence":"additional","affiliation":[{"name":"Department of Food and Nutritional Sciences, Faculty of Science and Technology University of Central Punjab  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waleed","family":"Sultan","sequence":"additional","affiliation":[{"name":"Department of Food and Nutritional Sciences, Faculty of Science and Technology University of Central Punjab  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian\u2010Ya","family":"Qian","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering Yangzhou University  Yangzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4105-8615","authenticated-orcid":false,"given":"Esther Ugo","family":"Alum","sequence":"additional","affiliation":[{"name":"Department of Research and Publications Kampala International University  Kampala Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Shen","sequence":"additional","affiliation":[{"name":"Panvascular Diseases Research Center, Quzhou People's Hospital The Quzhou Affiliated Hospital of Wenzhou Medical University  Quzhou China"},{"name":"Laboratory of Food Nutrition and Clinical Research, Institute of Seafood Zhejiang Gongshang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1082013212452477"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2012.09.008"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.4236\/fns.2012.39164"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1043-6618(03)00214-7"},{"issue":"5","key":"e_1_2_10_6_1","first-page":"2035","article-title":"Date Seed and Date Seed Oil","volume":"20","author":"Abdul Afiq M. 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