{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:07:24Z","timestamp":1790172444975,"version":"4.1.0"},"reference-count":70,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T00:00:00Z","timestamp":1756944000000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2025,9]]},"abstract":"ABSTRACT<\/jats:title>\n \n The objective of this investigation was to assess the biological properties of the leaf's aqueous extract of\n Paronychia Arabica<\/jats:italic>\n (PaAE), which is used in conventional medicine for therapeutic purposes of gastric ulcers and abdominal diseases. The content of phenolic and flavonoidic compounds was quantitatively estimated using colorimetric methods. The phenolic component profile was also evaluated using LC\u2013MS\/MS. The biological activities were then carried out, namely the antioxidant activity (DPPH test, \u03b2\u2010carotene bleaching and FRAP assays), the anti\u2010inflammatory impact, and the inhibitory effect of the \u03b1\u2010amylase enzyme was also examined. Lastly, antimicrobial activity against seven bacterial strains:\n \n Pseudomonas aeruginosa<\/jats:italic>\n <\/jats:styled-content>\n ,\n \n Escherichia coli<\/jats:italic>\n <\/jats:styled-content>\n ,\n \n Klebsiella pneumoniae<\/jats:italic>\n <\/jats:styled-content>\n ,\n Bacillus subtilis<\/jats:italic>\n ,\n \n Staphylococcus aureus<\/jats:italic>\n <\/jats:styled-content>\n ,\n \n Listeria monocytogenes<\/jats:italic>\n <\/jats:styled-content>\n , and\n \n Micrococcus luteus<\/jats:italic>\n <\/jats:styled-content>\n ; and one yeast:\n \n Candida albicans<\/jats:italic>\n <\/jats:styled-content>\n . The aqueous extract obtained by use of the decoction of leaves of\n \n P. arabica<\/jats:italic>\n <\/jats:styled-content>\n contains high levels of phenolics and flavonoids. Additionally, LC\u2013MS\u2013MS assessment of the phenolic profile revealed the existence of 16 chemical compounds and the major compounds are 35.9% cis\u2010p\u2010coumaric acid, 14.8% syringic acid, 9.61% sinapic acid, and 9.6% 8\u2010Hydroxyquinolin. The findings revealed that\n \n P. arabica<\/jats:italic>\n <\/jats:styled-content>\n extract has elevated antioxidant capacity in all tested samples; it also demonstrated a higher anti\u2010inflammatory activity. Antihyperglycemic activity is marked by a significant inhibitory effect on \u03b1\u2010amylase in\u00a0vitro with an IC\n 50<\/jats:sub>\n equal to 78.82\u2009\u00b1\u20093.4\u2009\u03bcg\/mL. Moreover, the\n \n Staphylococcus aureus<\/jats:italic>\n <\/jats:styled-content>\n strain had the highest sensitivity to\n \n P. arabica<\/jats:italic>\n <\/jats:styled-content>\n extract's antibacterial properties, whilst\n \n Micrococcus luteus<\/jats:italic>\n <\/jats:styled-content>\n and\n \n Klebsiella pneumoniae<\/jats:italic>\n <\/jats:styled-content>\n strains showed moderate sensitivity, and\n \n Escherichia coli<\/jats:italic>\n <\/jats:styled-content>\n displayed the greatest resistance.\n <\/jats:p>","DOI":"10.1002\/fsn3.70912","type":"journal-article","created":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T12:02:07Z","timestamp":1756987327000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Phenolic Compounds Analysis and In\u00a0Vitro Biological Activities of Aqueous Extract From Leaves of\n Paronychia Arabica<\/i>\n Collected in South Algeria"],"prefix":"10.1002","volume":"13","author":[{"given":"Walid","family":"Boussebaa","sequence":"first","affiliation":[{"name":"Laboratory of Valorization and Promotion of Saharan Resources (VPRS), Faculty of Mathematics and Matter Sciences University of Ouargla Ouargla Algeria"},{"name":"Scientific and Technical Research Center in Physico\u2010Chemical Analysis (CRAPC) Headquarters ex\u2010Pasna Industrial Zone Tipaza Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zehour","family":"Rahmani","sequence":"additional","affiliation":[{"name":"Laboratory of Valorization and Promotion of Saharan Resources (VPRS), Faculty of Mathematics and Matter Sciences University of Ouargla Ouargla Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saidi","family":"Mokhtar","sequence":"additional","affiliation":[{"name":"Laboratory of Valorization and Promotion of Saharan Resources (VPRS), Faculty of Mathematics and Matter Sciences University of Ouargla Ouargla Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Safia Ben","family":"Amor","sequence":"additional","affiliation":[{"name":"Higher School of Saharan Agriculture\u2014El Oued El Oued Algeria"},{"name":"Salama Lab Higher School of Saharan Agriculture\u2014El Oued El Oued Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bachari","family":"Khaldoun","sequence":"additional","affiliation":[{"name":"Scientific and Technical Research Center in Physico\u2010Chemical Analysis (CRAPC) Headquarters ex\u2010Pasna Industrial Zone Tipaza Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdellah","family":"Henni","sequence":"additional","affiliation":[{"name":"Laboratory of Dynamic Interactions and Reactivity of Systems University of Kasdi Merbah Ouargla Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magda 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