{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:08:52Z","timestamp":1790172532019,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T00:00:00Z","timestamp":1757808000000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Boehmeria caudata<\/jats:italic>\n                    (Urticaceae) is an unconventional food plant found extensively across the neotropical region, including Central and South America, where its leaves are consumed as vegetables and traditionally used to treat sore throats. This study aimed to analyze the phytochemical composition of the methanolic extract of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>B. caudata<\/jats:italic>\n                    <\/jats:styled-content>\n                    leaves (MEBCL) and explore its pharmacological effects through in\u00a0vitro\n                    <jats:italic>,<\/jats:italic>\n                    in\u00a0vivo\n                    <jats:italic>,<\/jats:italic>\n                    and\n                    <jats:italic>in silico<\/jats:italic>\n                    methods. GC\u2013MS investigation identified 14 phytochemicals, including two forms of Vitamin E. MEBCL exhibited a strong in\u00a0vitro antioxidant effect, with IC\n                    <jats:sub>50<\/jats:sub>\n                    values of 63.61\u2009\u03bcg\/mL for the DPPH assay as well as 130.66\u2009\u03bcg\/mL for the FRAP assay. In\u00a0vivo, MEBCL showed notable analgesic effects, as observed in both the acetic acid\u2010induced writhing model and the formalin\u2010induced paw\u2010licking model. MEBCL also showed significant anxiolytic actions in the elevated plus maze and hole board tests. Additionally, MEBCL significantly reduced immobility time in both the forced swimming as well as tail suspension tests, indicating its antidepressant properties. Molecular docking studies revealed that the phytochemicals in MEBCL exhibited significant binding affinity to key drug target proteins associated with oxidative stress, pain, anxiety, and depression. These compounds also have a favorable pharmacokinetic and safety profile, suggesting their potential as future drug candidates. Therefore, MEBCL can be a valuable reservoir of Vitamin E with notable antioxidant, analgesic, anxiolytic, and antidepressant effects. However, more in\u2010depth studies are essential to determine whether\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>B. caudata<\/jats:italic>\n                    <\/jats:styled-content>\n                    leaves can be effectively used as a functional food and therapeutic agent.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.70953","type":"journal-article","created":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T04:24:31Z","timestamp":1757910271000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Phytochemical and Bioactivity Profiling of Unconventional Food Plant,\n                    <i>Boehmeria caudata<\/i>\n                    Leaves:\n                    <scp>FT<\/scp>\n                    \u2010\n                    <scp>IR<\/scp>\n                    ,\n                    <scp>GC<\/scp>\n                    \u2013\n                    <scp>MS<\/scp>\n                    , Experimental, and In Silico Investigation"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-1945-6598","authenticated-orcid":false,"given":"Md. Liakot","family":"Ali","sequence":"first","affiliation":[{"name":"Department of Pharmacy Faculty of Biological Sciences, University of Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Ajib","family":"Jaber","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Faculty of Biological Sciences, University of Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihanul","family":"Hasan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Faculty of Biological Sciences, University of Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5877-8638","authenticated-orcid":false,"given":"Nawreen Monir","family":"Proma","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Faculty of Biological Sciences, University of Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neamul","family":"Hoque","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Faculty of Biological Sciences, University of Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Tashrif Rahman","family":"Tipu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Faculty of Biological Sciences, University of Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kutub Uddin","family":"Ahamed","sequence":"additional","affiliation":[{"name":"Pharmaceutical Sciences Research Division BCSIR Dhaka Laboratories, Bangladesh Council of Scientific and Industrial Research (BCSIR)  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bakul","family":"Akter","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Faculty of Biological Sciences, University of Chittagong  Chittagong Bangladesh"},{"name":"Pharmaceutical Sciences Research Division BCSIR Dhaka Laboratories, Bangladesh Council of Scientific and Industrial Research (BCSIR)  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bibi Humayra","family":"Khanam","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Faculty of Biological Sciences, University of Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3462-1086","authenticated-orcid":false,"given":"Mohammed Kamrul","family":"Hossain","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Faculty of Biological Sciences, University of Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,14]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11696-020-01126-0"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11418-017-1164-8"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/app12115594"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202402303"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpt.2024.07.003"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/JEP.S361194"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/741712"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11101912"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291716002828"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.4161\/oxim.2.2.7944"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1006\/cbir.2000.0553"},{"key":"e_1_2_12_13_1","first-page":"820","volume-title":"Illustrated Dictionary of Folk Medicine (Crude Drugs)","author":"Chung B. 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