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EGCG was administered via intraperitoneal injection, and liver function and blood lipid profiles were assessed. Western blot analysis was employed to determine the expression levels of caspase\u20101 and nuclear factor kappa B (NF\u2010\u03baB), as well as inflammatory factors interleukin\u20101\u03b2 (IL\u20101\u03b2) and interleukin\u201018 (IL\u201018). The results showed that CUMS induced depression\u2010like behaviors (including anhedonia and behavioral despair) in rats, accompanied by reduced body weight, decreased liver index, and dyslipidemia. Western blot analysis revealed significantly elevated expression of pyroptosis\u2010related proteins (NF\u2010\u03baB, cleaved\u2010caspase\u20101, IL\u20101\u03b2, and IL\u201018) in both the liver and brain tissues of the CUMS group. EGCG treatment could reverse these results. Notably, female rats exhibited more severe CUMS\u2010induced depression\u2010like behaviors than male rats. These findings suggest that EGCG can alleviate CUMS\u2010induced depression\u2010like behaviors (anhedonia and behavioral despair) in female rats. This protective effect may be mediated by inhibiting the NF\u2010\u03baB\/caspase\u20101 pyroptosis pathway, reducing IL\u20101\u03b2 and IL\u201018 expression, thereby improving hepatocellular pyroptosis and alleviating liver injury.<\/jats:p>","DOI":"10.1002\/fsn3.70961","type":"journal-article","created":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T05:13:40Z","timestamp":1758950020000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["(\u2212)\u2010Epigallocatechin Gallate Ameliorates Chronic Stress\u2010Induced Depression\u2010Like Behavior in Rats by Inhibiting the\n                    <scp>NF<\/scp>\n                    \u2010\n                    <scp>\u03baB<\/scp>\n                    \/Caspase\u20101 Signaling Pathway and Reducing\n                    <scp>IL<\/scp>\n                    \u20101\u03b2 and\n                    <scp>IL<\/scp>\n                    \u201018 Expression"],"prefix":"10.1002","volume":"13","author":[{"given":"Guixian","family":"Wu","sequence":"first","affiliation":[{"name":"School of Public Health Guilin Medical University  Guilin China"},{"name":"Guangxi Key Laboratory of Environmental Exposomics and Whole Life Cycle Health  Guilin China"},{"name":"Key Cultivation Laboratory of Life Cycle Health Care Research  Guilin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieyu","family":"Xu","sequence":"additional","affiliation":[{"name":"Guilin University of Aerospace Technology  Guilin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanhua","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Public Health Guilin Medical University  Guilin China"},{"name":"Guangxi Key Laboratory of Environmental Exposomics and Whole Life Cycle Health  Guilin China"},{"name":"Key Cultivation Laboratory of Life Cycle Health Care Research  Guilin 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