{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:08:29Z","timestamp":1790172509557,"version":"4.1.0"},"reference-count":71,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T00:00:00Z","timestamp":1758499200000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100013494","name":"West Light Foundation, Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["2018\u2010XBQNXZ\u2010A1\u2010002"],"award-info":[{"award-number":["2018\u2010XBQNXZ\u2010A1\u2010002"]}],"id":[{"id":"10.13039\/501100013494","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Donkey milk (DM) demonstrates promising bioactive properties, including anti\u2010inflammatory and microbiota\u2010modulating effects with therapeutic potential for ulcerative colitis (UC)\u2014though mechanistic research remains limited. To bridge this research gap, a standardized DSS\u2010induced murine UC model was established. Results indicated that daily DM administration markedly attenuated clinical manifestations of UC, such as reduced body weight, intestinal mucosal injury, and increased Disease Activity Index (DAI). Mechanistically, DM enhanced gut barrier integrity through transcriptional upregulation of key genes (\n                    <jats:italic>MUC2<\/jats:italic>\n                    ,\n                    <jats:italic>Reg3\u03b1<\/jats:italic>\n                    ,\n                    <jats:italic>Reg3g<\/jats:italic>\n                    ,\n                    <jats:italic>Occludin<\/jats:italic>\n                    ,\n                    <jats:italic>Alpi<\/jats:italic>\n                    ,\n                    <jats:italic>ZO\u20101<\/jats:italic>\n                    ) while suppressing inflammation via TLR4\/MyD88\/NF\u2010\u03baB cascade inhibition and concomitant reduction of proinflammatory cytokines (TNF\u2010\u03b1, IL\u20101\u03b2, IL\u201018). Cecal 16S rDNA sequencing further confirmed DM\u2010mediated microbial restoration, characterized by significant enrichment of beneficial genera (\n                    <jats:italic>Enterorhabdus<\/jats:italic>\n                    ,\n                    <jats:italic>Lachnoclostridium<\/jats:italic>\n                    ,\n                    <jats:italic>Parvibacter<\/jats:italic>\n                    ) and reduction of inflammation\u2010associated taxa (\n                    <jats:italic>Bacteroides<\/jats:italic>\n                    ,\n                    <jats:italic>norank_Muribaculaceae<\/jats:italic>\n                    ,\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">Eubacterium fissicatena<\/jats:styled-content>\n                      group\n                    <\/jats:italic>\n                    ). In conclusion, our integrated analysis validates DM as a nutraceutical intervention capable of simultaneously targeting mucosal healing, inflammation resolution, and microbiome restoration\u2014positioning it as a promising therapeutic and prophylactic approach for IBD spectrum disorders.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.70989","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T06:37:58Z","timestamp":1758609478000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Donkey Milk Improves Dextran Sulfate Sodium\u2010Induced Ulcerative Colitis by Protecting Gut Barrier Function, Inhibiting the TLR4\/MyD88\/NF\u2010\u03baB Signaling Pathway, and Modulating Gut Microbiota"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-8878-1539","authenticated-orcid":false,"given":"Lin","family":"Yang","sequence":"first","affiliation":[{"name":"Key Laboratory of Biological Resources and Ecology of Pamirs Plateau in Xinjiang Uygur Autonomous Region, College of Life and Geographic Sciences Kashi University  Kashi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Ni","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biological Resources and Ecology of Pamirs Plateau in Xinjiang Uygur Autonomous Region, College of Life and Geographic Sciences Kashi University  Kashi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaogang","family":"Gou","sequence":"additional","affiliation":[{"name":"Xinjiang Yukunlun Natural Food Engineering Co., Ltd.  Kashi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingqian","family":"Zhong","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biological Resources and Ecology of Pamirs Plateau in Xinjiang Uygur Autonomous Region, College of Life and Geographic Sciences Kashi University  Kashi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keyi","family":"Wen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biological Resources and Ecology of Pamirs Plateau in Xinjiang Uygur Autonomous Region, College of Life and Geographic Sciences Kashi University  Kashi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biological Resources and Ecology of Pamirs Plateau in Xinjiang Uygur Autonomous Region, College of Life and Geographic Sciences Kashi University  Kashi 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