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A PCOS mouse model was established using dehydroepiandrosterone (DHEA) induction. The effects of\n                    <jats:italic>Chlorella<\/jats:italic>\n                    supplementation were evaluated in\u00a0vivo to determine its potential for alleviating PCOS\u2010related symptoms.\n                    <jats:italic>Chlorella<\/jats:italic>\n                    treatment effectively reduced testosterone (T) and luteinizing hormone (LH) levels in mice with PCOS. Additionally,\n                    <jats:italic>Chlorella<\/jats:italic>\n                    modulated the expression of oxidative stress\u2010related genes and improved ovarian morphology and function. Notably,\n                    <jats:italic>Chlorella<\/jats:italic>\n                    also restored the gut microbiota from PCOS\u2010associated dysbiosis.\n                    <jats:italic>Chlorella<\/jats:italic>\n                    ameliorated PCOS symptoms by rebalancing ovarian steroid hormones, enhancing antioxidant defense, and modulating the gut microbiota. These findings support its potential as a natural therapeutic agent for PCOS management.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.70992","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T19:29:05Z","timestamp":1760556545000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Effects of\n                    <scp>\n                      <i>Chlorella vulgaris<\/i>\n                    <\/scp>\n                    on Polycystic Ovary Syndrome in Mice"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6003-1465","authenticated-orcid":false,"given":"Yu","family":"Sun","sequence":"first","affiliation":[{"name":"Institute of Aquatic Biotechnology, College of Life Sciences Qingdao University  Qingdao Shandong China"},{"name":"Shandong Center of Technology Innovation for Biological Breeding of Premium Fish (Preparatory)  Yantai Shandong 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