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This study investigated the neuroprotective effects of low\u2010molecular\u2010weight\n                    <jats:italic>Angelica sinensis<\/jats:italic>\n                    polysaccharide (LMW\u2010ASP) in a rat middle cerebral artery occlusion\/reperfusion (MCAO\/R) model. Structural characterization revealed that LMW\u2010ASP (3.9\u2009kDa), containing a pyranose ring and uronic acid, was a heteropolysaccharide that comprised fucose, galactosamine hydrochloride, rhamnose, arabinose, glucosamine hydrochloride, galactose, glucose, xylose, mannose, galacturonic acid, and glucuronic acid (0.007:0.003:0.057:0.209:0.009:0.284:0.303:0.006:0.032:0.083:0.007). Post\u2010stroke administration of LMW\u2010ASP (50\u2009mg\/kg) significantly improved body weight and neurological functions after MCAO\/R. Moreover, microtubule\u2010associated protein\u20102 expression was notably higher in the LMW\u2010ASP group than in the model group (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01). Furthermore, Golgi\u2010Cox staining confirmed that LMW\u2010ASP increased the number of dendritic intersections (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05 for 90\u2013120, 180, and 200\u2009\u03bcm;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001 for 70 and 80\u2009\u03bcm), the number of terminal branches (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01), the number of branch points (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01), and the density of basal dendritic spines (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Finally, transmission electron microscopy revealed an increase in the number of synapses (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) and presynaptic vesicles (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) in the LMW\u2010ASP group. These results suggest that LMW\u2010ASP is a potential pharmaceutical therapeutic approach for stroke recovery that enhances neuroplasticity.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.71010","type":"journal-article","created":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T07:16:27Z","timestamp":1758870987000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Low\u2010Molecular\u2010Weight\n                    <i>Angelica sinensis<\/i>\n                    Polysaccharide Improves Neurological Function and Neuroplasticity Following Cerebral Ischemia\u2013Reperfusion Injury"],"prefix":"10.1002","volume":"13","author":[{"given":"Junbin","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Neurological Rehabilitation Zhongnan Hospital of Wuhan University  Wuhan 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