{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T13:06:50Z","timestamp":1790168810785,"version":"4.1.0"},"reference-count":159,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T00:00:00Z","timestamp":1759190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T00:00:00Z","timestamp":1759190400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100017700","name":"Henan Provincial Science and Technology Research Project","doi-asserted-by":"publisher","award":["242102310523"],"award-info":[{"award-number":["242102310523"]}],"id":[{"id":"10.13039\/501100017700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017700","name":"Henan Provincial Science and Technology Research Project","doi-asserted-by":"publisher","award":["242102310578"],"award-info":[{"award-number":["242102310578"]}],"id":[{"id":"10.13039\/501100017700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017700","name":"Henan Provincial Science and Technology Research Project","doi-asserted-by":"publisher","award":["252102310525"],"award-info":[{"award-number":["252102310525"]}],"id":[{"id":"10.13039\/501100017700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Lycium barbarum<\/jats:italic>\n                    <\/jats:styled-content>\n                    is a plant that is a member of the Solanaceae family. Different tissues and organs from this plant are widely used in traditional Chinese medicine because of their abundant functional ingredients. Recently,\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Lycium barbarum<\/jats:italic>\n                    <\/jats:styled-content>\n                    has been the subject of several ethnopharmacological studies. With the deepening research and development of products utilizing functional ingredients, the edible value of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Lycium barbarum<\/jats:italic>\n                    <\/jats:styled-content>\n                    has been gradually explored, attracting the attention of scholars due to its excellent nutritional properties. In 1988, the fruits of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Lycium barbarum<\/jats:italic>\n                    <\/jats:styled-content>\n                    were officially included in the list of \u201cboth medicine and food\u201d by the Chinese Ministry of Health. Additionally, the bark and leaves of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Lycium barbarum<\/jats:italic>\n                    <\/jats:styled-content>\n                    are edible. Owing to its dual\u2010use characteristics in medicine and food,\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Lycium barbarum<\/jats:italic>\n                    <\/jats:styled-content>\n                    has been widely used as a traditional Chinese medicine and functional food worldwide. However, a comprehensive summary focused on the functional ingredients, pharmacological effects, food research and development status, and safety of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Lycium barbarum<\/jats:italic>\n                    <\/jats:styled-content>\n                    is lacking. Therefore, we reviewed the major functional ingredient categories, structural characteristics, and nutritional value. Furthermore, we summarize the pharmacological effects of the functional ingredients to support their further application as therapeutic agents. Food research and the development of functional ingredients from\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Lycium barbarum<\/jats:italic>\n                    <\/jats:styled-content>\n                    are also systematically reviewed. Finally, this review provides a comprehensive overview of the safety and future development of products derived from\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Lycium barbarum<\/jats:italic>\n                    <\/jats:styled-content>\n                    , exploring potential applications in the fields of cosmetics, agriculture, functional foods, and nutritional supplements of its bioactive constituents, with the aim of facilitating further extensive investigations into its utilization.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.71018","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T10:32:12Z","timestamp":1759228332000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Health Benefits and Food Applications of Bioactive Constituents From Different Medicinal Parts (Bark, Leaf, and Fruit) of\n                    <i>Lycium barbarum<\/i>"],"prefix":"10.1002","volume":"13","author":[{"given":"Mengfan","family":"Peng","sequence":"first","affiliation":[{"name":"Faculty of Medicine HuangHuai University  Zhumadian China"},{"name":"NMPA Key Laboratory for Safety Research and Evaluation of Traditional Chinese Medicine Henan University of Chinese Medicine  Zhengzhou China"},{"name":"Department of Pharmacy Zhumadian Traditional Chinese Medicine Hospital  Zhumadian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caixia","family":"Li","sequence":"additional","affiliation":[{"name":"NMPA Key Laboratory for Safety Research and Evaluation of Traditional Chinese Medicine Henan University of Chinese Medicine  Zhengzhou China"},{"name":"The First Affiliated Hospital of Xinxiang Medical University  Xinxiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Yang","sequence":"additional","affiliation":[{"name":"Faculty of Medicine HuangHuai University  Zhumadian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Ye","sequence":"additional","affiliation":[{"name":"Faculty of Medicine HuangHuai University  Zhumadian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1013-8724","authenticated-orcid":false,"given":"Baosong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Zhumadian Traditional Chinese Medicine Hospital  Zhumadian China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/17455057231176655"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.16050\/j.cnki.issn1674\u20106309.2023.05.005"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.13386\/j.issn1002\u20100306.2022110055"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2014.01.067"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22020341"},{"key":"e_1_2_10_7_1","first-page":"262","article-title":"Pharmacological Effects and Application of Different Doses of Cortex Lycii","volume":"4","author":"Cao J.","year":"2002","journal-title":"Journal of Clinical and Experimental Medicine"},{"issue":"9","key":"e_1_2_10_8_1","first-page":"23","article-title":"Effects of the Flavonoids From Lycium Barbarum Leaves on Fatty Acids of Compound Minced Mutton","volume":"43","author":"Chen J.","year":"2018","journal-title":"China Condiment"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.16695\/j.cnki.1006\u20102947.2022.04.012"},{"issue":"12","key":"e_1_2_10_10_1","first-page":"1486","article-title":"Lycium Barbarum Polysaccharide Improves Endothelium\u2010Dependent Vascular Relaxation in Diabetic Rats by Down\u2010Regulating the Calpain\u20101 Protein Expression","volume":"43","author":"Chen W.","year":"2023","journal-title":"Chinese Journal of Integrated Traditional and Western Medicine"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.13982\/j.mfst.1673\u20109078.2013.05.016"},{"issue":"11","key":"e_1_2_10_12_1","first-page":"2023","article-title":"Hypoglycemic Effect of Digupi Water Decoction on Three High Blood Glucose Models in Mice","volume":"19","author":"Cui C.","year":"2016","journal-title":"China Pharmacist"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2019.4544"},{"key":"e_1_2_10_14_1","volume-title":"The Mechanism Study Evaluating the Anti\u2010Colitis of Total Flavonoids of Lycium Barbarum","author":"Deng M.","year":"2023"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/1534735417753544"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1039\/c9fo00638a"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.13386\/j.issn1002\u20100306.2023060225"},{"issue":"12","key":"e_1_2_10_18_1","first-page":"32","article-title":"Study on Free Radical Scavenging Effect of Flavonoids From Lycium Barbarum Leaves In\u00a0Vitro","volume":"42","author":"Fan Y.","year":"2017","journal-title":"China Condiment"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.19664\/j.cnki.1002\u20102392.2004.04.026"},{"issue":"18","key":"e_1_2_10_20_1","first-page":"185","article-title":"Lycium Ruthenicum Murray Fruit: Chemical Composition Analysis by Ultra\u2010High Performance Liquid Chromatography Coupled to Triple Time of Flight Mass Spectrometry and Determination of Total Anthocyanins","volume":"42","author":"Gan X.","year":"2021","journal-title":"Food Science"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2017.0725"},{"issue":"3","key":"e_1_2_10_22_1","first-page":"136","article-title":"Study on Hypoglycemic Activity of Lycium Barbarum Polysaccharides","volume":"45","author":"Guo F.","year":"2024","journal-title":"Food Industry"},{"key":"e_1_2_10_23_1","volume-title":"Study on Extraction and Purification of Lycium barbarum Pigment and Its Stability and Oxidation Resistance","author":"Guo X.","year":"2023"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2024.1416793"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756360902779193"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.13386\/j.issn1002\u20100306.2023110273"},{"key":"e_1_2_10_27_1","volume-title":"Tropane Alkaloids From Lycium barbarum linn., In\u00a0Vivo and In\u00a0Vitro","author":"Harsh M.","year":"1989"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2018.12.001"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.13982\/j.mfst.1673\u20109078.2019.11.006"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.16593\/j.cnki.41\u20101433\/s.2021.04.033"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.9b04411"},{"issue":"22","key":"e_1_2_10_32_1","first-page":"3315","article-title":"Research Progress on Cortex Lycii Radices in the Treatment of Diabetes Mellitus","volume":"33","author":"Huang X.","year":"2018","journal-title":"Guangming Journal of Chinese Medicine"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.921075"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2008.04.001"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2009.09.006"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.13901\/j.cnki.qhwxxbzk.2022.05.006"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.13194\/j.issn.1673\u2010842x.2014.03.001"},{"issue":"3","key":"e_1_2_10_38_1","first-page":"140","article-title":"Lycium Barbarum Polysaccharide Induced Apoptosis of Human Tongue Squamous Cancer CAL\u201027 Cells via the p53 Pathway","volume":"38","author":"Jiang M.","year":"2022","journal-title":"Journal of Clinical Stomatology"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2015.03.029"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.14053\/j.cnki.ppcr.202012003"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2016.2477"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41538\u2010022\u201000149\u2010z"},{"key":"e_1_2_10_43_1","volume-title":"Effects of Total Flavonoids in Lycium Chinensis Leaves on Proliferation and Apoptosis of Hepatoma Cell Line HepG2","author":"Lei L.","year":"2014"},{"key":"e_1_2_10_44_1","first-page":"599","article-title":"Law of Changes of Carotenoids Contents in Fructus Lycii of Chinese Wolfberry (Lycium Barbarum L.) at Different Mature Periods","volume":"3","author":"Li H.","year":"2006","journal-title":"Scientia Agricultura Sinica"},{"issue":"12","key":"e_1_2_10_45_1","first-page":"7","article-title":"Comparative Analysis of Main Components and In\u00a0Vitro Antioxidant Activities of Lycium Barbarum Fruits From Different Producing Areas","volume":"45","author":"Li M.","year":"2024","journal-title":"Food Research and Development"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.13610\/j.cnki.1672\u2010352x.20211022.003"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23040973"},{"key":"e_1_2_10_48_1","volume-title":"Study on Dynamic Accumulation of Chemical Constituents and Antioxidant and Hypoglycemic Activity in Lycii Cortex","author":"Li X.","year":"2023"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.13386\/j.issn1002\u20100306.2024020180"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.19664\/j.cnki.1002\u20102392.2003.02.017"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.13863\/j.issn1001\u20104454.2011.08.034"},{"issue":"11","key":"e_1_2_10_52_1","first-page":"5149","article-title":"The Mechanism of Quercetin in Regulating Osteoclast Activation and the PAR2\/TRPV1 Signaling Pathway in the Treatment of Bone Cancer Pain","volume":"11","author":"Li Z.","year":"2018","journal-title":"International Journal of Clinical and Experimental Pathology"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.16050\/j.cnki.issn1674\u20106309.2023.07.001"},{"issue":"6","key":"e_1_2_10_54_1","first-page":"222","article-title":"Response of Antioxidative Enzymes Activities and Amino Acids Concentrations in Leaf Tissues of Lycium Barbarum L. Seedlings Under Cadmium Stress","volume":"16","author":"Liang X.","year":"2021","journal-title":"Asian Journal of Ecotoxicology"},{"issue":"10","key":"e_1_2_10_55_1","first-page":"1853","article-title":"Effects of IL\u201033\/ST2 Signal on Immune Function and Sodium Channel in Otitis Media Rats by Using Tiosteopantin","volume":"39","author":"Liao J.","year":"2023","journal-title":"Chinese Pharmacological Bulletin"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.972794"},{"key":"e_1_2_10_57_1","volume-title":"Study on the Anti\u2010Fatigue and Anti\u2010Diabetes Effects of Lycium barbarum L. Water Extracts by Regulating Oxidative Stress Pathway","author":"Liu H.","year":"2020"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1039\/d1fo02667d"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.13885\/j.issn.1000\u20102812.2020.03.007"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.19540\/j.cnki.cjcmm.20190325"},{"issue":"4","key":"e_1_2_10_61_1","first-page":"396","article-title":"Acute Toxicity of Ethyl Acetate Extraction From Fructus Lycii and Its Effect on Osteoporosis in Ovariectomized Rats","volume":"22","author":"Liu T.","year":"2016","journal-title":"Chinese Journal of Osteoporosis"},{"issue":"24","key":"e_1_2_10_62_1","first-page":"6302","article-title":"Neuroprotective Effects of Kukoamine a Against Rotenone\u2010Induced Neurotoxicity in PC12 Cells","volume":"51","author":"Liu W.","year":"2020","journal-title":"Chinese Traditional and Herbal Drugs"},{"key":"e_1_2_10_63_1","volume-title":"Study on Extraction, Purification, Characterization and Biological Activity of Polysaccharides From Lycium Ruthenicum Leaves","author":"Liu Y.","year":"2016"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.13386\/j.issn1002\u20100306.2016.18.057"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygeno.2021.11.030"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.14084\/j.cnki.cn62\u20101188\/n.2019.03.013"},{"issue":"8","key":"e_1_2_10_67_1","first-page":"8","article-title":"Research Progress on Chemical Constituents of Lycii Cortex","volume":"48","author":"Lu L.","year":"2021","journal-title":"Yunnan Chemical Technology"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.13386\/j.issn1002\u20100306.2019.24.027"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.13313\/j.issn.1673\u20104890.20181225001"},{"key":"e_1_2_10_70_1","first-page":"137","article-title":"Immunomodulatory Effects of Spray Dried Powder of Goji (Lycium Barbarum L.) and Goji Polysaccharides on Immunosuppressive Mice Induced by Cyclophosphamide and Their Regulation on Gut Microbiota","volume":"43","author":"Luo Q.","year":"2022","journal-title":"Food Science"},{"issue":"1","key":"e_1_2_10_71_1","first-page":"249","article-title":"Preparation and Analyses of Textural Quality and Flavor Substances of Goji Berry Yoghurt","volume":"40","author":"Luo Y.","year":"2024","journal-title":"Modern Food Science and Technology"},{"key":"e_1_2_10_72_1","volume-title":"Comprehensive Evaluation of the Main Chemical Components and Biological Activities of Goji Leaves and Study on Their High\u2010Efficient Extraction and Enrichment Technology","author":"Lv M. J.","year":"2021"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.2095\u20104344.2016.15.007"},{"key":"e_1_2_10_74_1","volume-title":"Comprehensive Extraction of Active Substances From Lycium Barbarum L. Leaves and Screening of Their Biological Activities In\u00a0Vitro","author":"Ma M.","year":"2024"},{"key":"e_1_2_10_75_1","first-page":"153","article-title":"The Effects of Compound Goji Berry Leaf Tea on Fatigue Resistance, Hypoxia Tolerance, Low Temperature Tolerance, and Blood Lipids","volume":"2","author":"Ma Q.","year":"2000","journal-title":"Journal of Xinjiang Medical University"},{"issue":"17","key":"e_1_2_10_76_1","first-page":"316","article-title":"Progress in Research and Application of Phenols and Their Derivatives From Lycium Barbarum L","volume":"45","author":"Ma Q.","year":"2024","journal-title":"Food Science"},{"key":"e_1_2_10_77_1","volume-title":"Study on the Difference of Biosynthesis of Flavonoids in \u2018Ningqi No.1\u2019 Lycium Barbarum From Different Regions Based on Multiomics Technology","author":"Ma R.","year":"2024"},{"key":"e_1_2_10_78_1","unstructured":"Mei L.2016.\u201cResearch and Industrialization of Chaidamu Goji Leaf Flavonoids Compound Soft Capsules.\u201d"},{"key":"e_1_2_10_79_1","first-page":"88","article-title":"Preliminary Study for the Anticancer Activity of Flavonoids Extracted From Wild Lycium Barbarum Leaves","volume":"3","author":"Mohammed Z.","year":"2024","journal-title":"International Journal of Research Studies in Biosciences"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.13213\/j.cnki.jeom.2002.03.089"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27154952"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2012.03.020"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.201700277"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules191219594"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.2174\/0113862073273655231213070619"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.13386\/j.issn1002\u20100306.2024040128"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11112716"},{"issue":"27","key":"e_1_2_10_88_1","first-page":"2513","article-title":"Protective Effects of Lycii Cortex Ethanol Extract on Diabetic Model Rats","volume":"25","author":"Peng H.","year":"2014","journal-title":"China Pharmacy"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e27870"},{"key":"e_1_2_10_90_1","first-page":"255","article-title":"Antihypertensive Effect of Cortex Lycii and Lotus Leaf","volume":"3","author":"Pharmacology Teaching and Research Group","year":"1959","journal-title":"Journal of Nanjing Medical University (Natural Sciences)"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.3390\/pr8111388"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.16421\/j.cnki.1002\u20103127.1988.03.019"},{"key":"e_1_2_10_93_1","volume-title":"A Lipid\u2010Lowering and Hypoglycemic Cortex Lycii Health Tea and Its Preparation Method","author":"Qingdao Hengbo Instrument Co., Ltd","year":"2014"},{"key":"e_1_2_10_94_1","volume-title":"A Type of Health Tea Made From Cortex Lycii That Enhances Immunity and Its Preparation Method","author":"Qingdao Hengbo Instrument Co., Ltd","year":"2017"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.16695\/j.cnki.1006\u20102947.2020.04.003"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.16808\/j.cnki.issn1003\u20107705.2020.11.070"},{"key":"e_1_2_10_97_1","volume-title":"Isolation, Purification, Structural Characterization, and Hypoglycemic Activity Analysis of Polysaccharides From Goji Berry Leaves","author":"Quan N.","year":"2018"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28093880"},{"issue":"9","key":"e_1_2_10_99_1","first-page":"2405","article-title":"Inhibitory Effect of Lycium Barbarum Polysaccharide on Proliferation of Human Esophageal Carcinoma Cells and the Relationship With Rb Protein Expression","volume":"21","author":"Shan T.","year":"2010","journal-title":"Lishizhen Medicine and Materia Medica Research"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.13729\/j.issn.1671\u20107813.Z20232383"},{"issue":"17","key":"e_1_2_10_101_1","first-page":"39","article-title":"The Nutritional Value and Health Function of Lycium Barbarum and Its Application Progress","volume":"26","author":"Shao C.","year":"2020","journal-title":"Anhui Agricultural Science Bulletin"},{"issue":"2","key":"e_1_2_10_102_1","first-page":"213","article-title":"Analyzing the Autotoxicity of Phenolic Acids From Lycium Barbarum L. Leaves","volume":"40","author":"Song Y.","year":"2024","journal-title":"Jiangsu Journal of Agricultural Sciences"},{"issue":"2","key":"e_1_2_10_103_1","first-page":"1","article-title":"Research Progress on Extraction, Separation, Purification, and Pharmacological Activities of Pigments Extracted From Lycium Barbarum","volume":"43","author":"Su Y.","year":"2024","journal-title":"Chinese Archives of Traditional Chinese Medicine"},{"key":"e_1_2_10_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2023.120725"},{"key":"e_1_2_10_105_1","doi-asserted-by":"publisher","DOI":"10.16680\/j.1671\u20103826.2022.03.04"},{"key":"e_1_2_10_106_1","doi-asserted-by":"publisher","DOI":"10.13746\/j.njkj.2020129"},{"key":"e_1_2_10_107_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871523019666200124114503"},{"issue":"1","key":"e_1_2_10_108_1","first-page":"48","article-title":"Researches on Effective Fraction and Mechanism of Lycium Barbarum Leaves on Improving Learning and Memory Abilities of D\u2010Galactose\u2010Induced Subacute Aging Mice","volume":"26","author":"Tong J.","year":"2024","journal-title":"Modernization of Traditional Chinese Medicine and Materia Medica\u2010World Science and Technology"},{"issue":"3","key":"e_1_2_10_109_1","first-page":"261","article-title":"Preliminary Study on Antidepressant Effect of Total Flavonoids of Lycium Barbarum Leaves","volume":"36","author":"Wang C.","year":"2015","journal-title":"Journal of Ningxia University (Natural Science Edition)"},{"key":"e_1_2_10_110_1","first-page":"47","article-title":"The Effects of Lycium Barbarum on the Immunopharmacdogical Activity of the Mice","volume":"1","author":"Wang H.","year":"2006","journal-title":"Jinzhou Medical University"},{"key":"e_1_2_10_111_1","doi-asserted-by":"publisher","DOI":"10.16050\/j.cnki.issn1674\u20106309.2015.03.001"},{"key":"e_1_2_10_112_1","doi-asserted-by":"publisher","DOI":"10.19870\/j.cnki.11\u20103716\/ts.20201106.001"},{"issue":"5","key":"e_1_2_10_113_1","first-page":"1540","article-title":"Chemical Constituents of Methanol Fraction From Lycii Cortex and Their Anti\u2010Inflammatory Activities","volume":"46","author":"Wang L.","year":"2024","journal-title":"Chinese Traditional Patent Medicine"},{"key":"e_1_2_10_114_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep36543"},{"key":"e_1_2_10_115_1","first-page":"39","article-title":"Effects of Lycium Barbarum and Lycii Cortex Polysaccharides on Immune System in Mice","volume":"3","author":"Wang Q.","year":"1993","journal-title":"Pharmacology and Clinics of Chinese Materia Medica"},{"issue":"18","key":"e_1_2_10_116_1","first-page":"40","article-title":"Optimization of Fermentation Technology and Analysis of Flavor Substances of Wolfberry","volume":"41","author":"Wang Y.","year":"2020","journal-title":"Food Research and Development"},{"issue":"5","key":"e_1_2_10_117_1","first-page":"896","article-title":"Effects of Lycium Barbarum Polysaccharide Combined With Cisplatinon Inhibitory and Immune Function of Hepatic Cancer Mice","volume":"37","author":"Wang Z.","year":"2018","journal-title":"Journal of Southeast University (Medical Science Edition)"},{"key":"e_1_2_10_118_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2016.4879"},{"issue":"11","key":"e_1_2_10_119_1","first-page":"2513","article-title":"Research Progress on Chemical Components and Pharmacological Activities of Ningxia Wolfberry","volume":"40","author":"Wei X.","year":"2018","journal-title":"Chinese Traditional Patent Medicine"},{"issue":"11","key":"e_1_2_10_120_1","first-page":"2786","article-title":"Study on the Hypoglycemic Effect of Ningxia Goji Berry Leaves at Different Harvesting Periods","volume":"23","author":"Wei Z.","year":"2012","journal-title":"Lishizhen Medicine and Materia Medica Research"},{"issue":"4","key":"e_1_2_10_121_1","first-page":"848","article-title":"The Effective Components From Cortex Lycii for Reduction of Blood Sugar","volume":"20","author":"Wei Z.","year":"2009","journal-title":"Lishizhen Medicine and Materia Medica Research"},{"key":"e_1_2_10_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2023.04.018"},{"key":"e_1_2_10_123_1","volume-title":"Study of Flavonoids in Lycium barbarum Leaves on Changes in Meat Quality Associated With Broiler Chickens Induced by Short\u2010Duration Transport Stress","author":"Wu X.","year":"2022"},{"key":"e_1_2_10_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2014.01.029"},{"key":"e_1_2_10_125_1","volume-title":"Research on Anti\u2010Aging Activity of the Goji Berry Extracts and Mechanism of Action","author":"Xiong L.","year":"2021"},{"issue":"4","key":"e_1_2_10_126_1","article-title":"Dual Directional Regulatory Effect of Partially Tonifying Solid Traditional Chinese Medicine on IL\u20102 Production in Mouse Spleen Cells","volume":"3","author":"Xiong X.","year":"1991","journal-title":"Chinese Journal of Experimental and Clinical Immunology"},{"issue":"5","key":"e_1_2_10_127_1","first-page":"450","article-title":"Research Progress on the Chemical Constituents and Biological Effects of Cortex Lycii","volume":"51","author":"Xu H.","year":"2021","journal-title":"China Surfactant Detergent & Cosmetics"},{"issue":"11","key":"e_1_2_10_128_1","first-page":"57","article-title":"Determination of Active Ingredient Content and Immune Performance in Lycium Barbarum Production and Processing Waste","volume":"33","author":"Yan H.","year":"2012","journal-title":"Feed Industry"},{"issue":"7","key":"e_1_2_10_129_1","first-page":"1193","article-title":"Evaluating the Differences in Different Parts of Lycium Barbarum L. by Fingerprint\u2010Based Chemical Pattern Recognition Method and Multi\u2010Index Determination","volume":"44","author":"Yan Y.","year":"2024","journal-title":"Journal of Hunan University of Chinese Medicine"},{"issue":"6","key":"e_1_2_10_130_1","first-page":"1079","article-title":"Nutritional, Phytochemical Characterization and Antioxidant Capacity of Ningxia Wolfberry (Lycium Barbarum L.)","volume":"36","author":"Yan Y.","year":"2014","journal-title":"Journal of the Chemical Society of Pakistan"},{"key":"e_1_2_10_131_1","doi-asserted-by":"publisher","DOI":"10.16254\/j.cnki.53\u20101120\/r.2011.08.037"},{"key":"e_1_2_10_132_1","doi-asserted-by":"publisher","DOI":"10.13193\/j.archtcm.2008.10.93.yangl.056"},{"issue":"5","key":"e_1_2_10_133_1","first-page":"8","article-title":"Experimental Study on the Improvement of Insulin Resistance in Rats With Type 2 Diabetes Mellitus With Cortex Lycii Radicis Based on AMPK\/GLUT4\/GSK3\u03b2\/PPAR\u03b1 Signaling Pathway","volume":"17","author":"Yao H.","year":"2020","journal-title":"China Medical Herald"},{"key":"e_1_2_10_134_1","doi-asserted-by":"publisher","DOI":"10.4314\/ajtcam.v10i4.27"},{"issue":"9","key":"e_1_2_10_135_1","first-page":"3078","article-title":"Optimization of Purification Process and Study on Composition and Antioxidant Activity of Polyphenols From Goji Berry","volume":"46","author":"Yin F.","year":"2024","journal-title":"Chinese Traditional Patent Medicine"},{"key":"e_1_2_10_136_1","volume-title":"Study on Anti\u2010Lung Cancer Effect and Mechanism of Extracts of Lycii Radicis Cortex","author":"Yin H.","year":"2021"},{"issue":"18","key":"e_1_2_10_137_1","first-page":"279","article-title":"The Effect of the Extracts of Some Crude Drugs on Proliferation of Osteoblast\u2010Like UMR106cells","volume":"4","author":"Yin J.","year":"2001","journal-title":"Journal of Shenyang Pharmaceutical University"},{"key":"e_1_2_10_138_1","doi-asserted-by":"publisher","DOI":"10.1039\/d2fo02886g"},{"issue":"7","key":"e_1_2_10_139_1","first-page":"517","article-title":"Effect of Digupi Extracts on the Expression of PPAR\u03b3 on 3T3\u2010L1 Fat Cells Induced by Lipopolysaccha\u2010Ride","volume":"22","author":"Yu M.","year":"2012","journal-title":"Zhejiang JITCWM"},{"key":"e_1_2_10_140_1","doi-asserted-by":"publisher","DOI":"10.16581\/j.cnki.issn1671\u20103206.2021.04.001"},{"issue":"5","key":"e_1_2_10_141_1","first-page":"1182","article-title":"Exploration of the Active Domain of Polysaccharide LBP1C\u20102 Targeting \u03b2\u2010Subunit\u20102 of Voltage\u2010Gated Potassium Channel","volume":"26","author":"Zeng H.","year":"2024","journal-title":"Modernization of Traditional Chinese Medicine and Materia Medica\u2014World Science and Technology"},{"key":"e_1_2_10_142_1","volume-title":"Structural Characterization, Digestive Characteristics and Biological Activities of Polysaccharides From Lycium barbarum","author":"Zeng W.","year":"2022"},{"issue":"2","key":"e_1_2_10_143_1","first-page":"626","article-title":"Effect of Lycium Barbarum Polysaccharide on Insulin Resistance in Pregnant Diabetes Rats by Regulating Nrf2\/HO\u20101\/GPX4 Iron Death Pathway","volume":"46","author":"Zhang C.","year":"2024","journal-title":"Chinese Traditional Patent Medicine"},{"issue":"11","key":"e_1_2_10_144_1","first-page":"2634","article-title":"Effects of Total Flavonoids of Lycium Barbarum L.on Proliferation and Apoptosis of Human Gastric Cancer Cell Lines SGC\u20107901","volume":"25","author":"Zhang D.","year":"2014","journal-title":"Lishizhen Medicine and Materia Medica Research"},{"key":"e_1_2_10_145_1","first-page":"13","article-title":"Fructus Lycii Influence Investigation to Thymus Function in D\u2010Galactose In\u2010Duced Immunosenescence Mouse Model","volume":"21","author":"Zhang H.","year":"2008","journal-title":"China Medical Herald"},{"key":"e_1_2_10_146_1","doi-asserted-by":"publisher","DOI":"10.13982\/j.mfst.1673\u20109078.2022.11.0035"},{"key":"e_1_2_10_147_1","doi-asserted-by":"publisher","DOI":"10.13995\/j.cnki.11\u20101802\/ts.037637"},{"key":"e_1_2_10_148_1","doi-asserted-by":"publisher","DOI":"10.16438\/j.0513\u20104870.2023\u20101449"},{"issue":"16","key":"e_1_2_10_149_1","first-page":"1","article-title":"Study on the Hypoglycemic Activity of Flavonoids From \n                     Lycium barbarum\n                  . Heilongjiang","volume":"13","author":"Zhang W.","year":"2022","journal-title":"Science"},{"key":"e_1_2_10_150_1","doi-asserted-by":"publisher","DOI":"10.13193\/j.issn.1673\u20107717.2024.01.032"},{"key":"e_1_2_10_151_1","doi-asserted-by":"publisher","DOI":"10.13995\/j.cnki.11\u20101802\/ts.025203"},{"issue":"20","key":"e_1_2_10_152_1","first-page":"5714","article-title":"The Effect of Lycium Barbarum Polysaccharide Capsules on Acute Toxicity in Mice","volume":"35","author":"Zhao R.","year":"2015","journal-title":"Chinese Journal of Gerontology"},{"key":"e_1_2_10_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.109559"},{"key":"e_1_2_10_154_1","volume-title":"Study on Resource Chemistry of Lycium Barbarum Leaves and Flowers","author":"Zhao X. Q.","year":"2020"},{"key":"e_1_2_10_155_1","doi-asserted-by":"publisher","DOI":"10.16438\/j.0513\u20104870.2022\u2010200626"},{"key":"e_1_2_10_156_1","doi-asserted-by":"publisher","DOI":"10.1039\/d2fo02788g"},{"key":"e_1_2_10_157_1","doi-asserted-by":"publisher","DOI":"10.14148\/j.issn.1672\u20100482.2023.0839"},{"key":"e_1_2_10_158_1","doi-asserted-by":"publisher","DOI":"10.14088\/j.cnki.issn.0439\u20108114.2022.18.021"},{"key":"e_1_2_10_159_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2013.04.057"},{"issue":"24","key":"e_1_2_10_160_1","first-page":"37","article-title":"Application Status and Industrial Development Strategy of Goji Berry for Leaf Use. Contemporary","volume":"45","author":"Zhu Y.","year":"2022","journal-title":"Horticulture"}],"container-title":["Food Science &amp; Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/fsn3.71018","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/fsn3.71018","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/fsn3.71018","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T12:41:00Z","timestamp":1790167260000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/fsn3.71018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,30]]},"references-count":159,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1002\/fsn3.71018"],"URL":"https:\/\/doi.org\/10.1002\/fsn3.71018","archive":["Portico"],"relation":{},"ISSN":["2048-7177","2048-7177"],"issn-type":[{"value":"2048-7177","type":"print"},{"value":"2048-7177","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,30]]},"assertion":[{"value":"2025-06-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71018"}}