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However, its lipid\u2010lowering potential and ability to alleviate metabolic syndrome (MS) remain unexplored. This study aimed to confirm the therapeutic effects of ECG on postmenopausal MS and investigate its underlying mechanisms. An animal model of female postmenopausal\n                    <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>\n                    was established using 8\u2010week\u2010old ovariectomized (\n                    <jats:styled-content style=\"fixed-case\">OVX<\/jats:styled-content>\n                    ) mice. Starting from the third week after model establishment, the mice were orally administered at the doses of 25, 50, and 100\u2009mg\/kg for 12 consecutive weeks.\n                    <jats:styled-content style=\"fixed-case\">HepG2<\/jats:styled-content>\n                    cells co\u2010induced by oleic acid and palmitic acid (\n                    <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content>\n                    &amp;\n                    <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content>\n                    ) were used as an in\u00a0vitro model. Ultra\u2010high\u2010performance liquid chromatography\u2010Q\u2010Exactive (\n                    <jats:styled-content style=\"fixed-case\">UHPLC<\/jats:styled-content>\n                    \u2010Q\u2010Exactive) analysis, histological examination, immunofluorescence, network pharmacology, molecular docking, molecular dynamics simulations, and other methods were employed for further analysis. ECG contains ingredients such as naringin and narirutin. In\u00a0vitro experiments showed that ECG intervention significantly reduced reactive oxygen species (ROS) accumulation and downregulated the mRNA expression of\n                    <jats:italic>Srebp1, G6, Fas, Pgc1\u03b1, Acc, Casp1, Nfkb, IL1\u03b2, IL6, Txnip, Nlrp3<\/jats:italic>\n                    , and\n                    <jats:italic>ASC<\/jats:italic>\n                    . Additionally, ECG inhibited the protein expression of NF\u2010\u03baB, Txnip, NLRP3, ASC, and Caspase\u20101, while enhancing the expression of Trx\u20101. In\u00a0vivo, ECG alleviated metabolic disorders in OVX mice by reducing lipid accumulation, attenuating inflammatory responses, and inhibiting NLRP3 inflammasome activation. Network pharmacology analysis and molecular dynamics identified the PI3K\/AKT1 signaling pathway as a crucial target mediating the functional effects of ECG. ECG exerts therapeutic benefits in ameliorating postmenopausal MS\u2010related metabolic disorders by inhibiting inflammatory responses, suppressing NLRP3 inflammasome activation, and modulating the PI3K\/AKT1 signaling pathway, providing new insights into the application of ECG for managing postmenopausal MS.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.71074","type":"journal-article","created":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:14:01Z","timestamp":1761707641000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["<i>Exocarpium Citri Grandis<\/i>\n                    Ameliorates Metabolic Disorders by Inhibiting Inflammatory Responses and NLRP3 Inflammasome Activation"],"prefix":"10.1002","volume":"13","author":[{"given":"Tingting","family":"Chen","sequence":"first","affiliation":[{"name":"State Key Laboratory of Traditional Chinese Medicine Syndrome, Science and Technology Innovation 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