{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T06:39:09Z","timestamp":1792478349132,"version":"4.5.0"},"reference-count":67,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T00:00:00Z","timestamp":1760745600000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Syzygium grande<\/jats:italic>\n                    <\/jats:styled-content>\n                    (Wight) Walp., commonly known as the sea apple, is valued for its wide range of uses. This study aimed to investigate the pharmacological effects of a methanol extract obtained from the leaves of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>S. grande<\/jats:italic>\n                    <\/jats:styled-content>\n                    (MESG) in Swiss albino mice. The extract's anxiolytic potential was assessed using the elevated plus maze (EPM), hole\u2010board test (HBT), and light\u2013dark test (LDT). Its antidepressant activity was evaluated through the forced swimming test (FST) and tail suspension test (TST). Sedative properties were measured using the open field test (OFT) and hole\u2010cross test (HCT), while antipyretic activity was determined through a yeast\u2010induced fever model. To identify active compounds in the extract, GC\u2013MS\/MS analysis was conducted. Additionally, computational approaches\u2014including AutoDock Vina, Discovery Studio 2021, PASS online, and ADME\/T platforms\u2014were employed for PASS prediction analysis, ADME\/T profiling, and molecular docking of various secondary metabolites. The findings indicated that MESG exhibited dose\u2010dependent anxiolytic, antidepressant, sedative, and antipyretic effects. A 400 mg\/kg dose significantly enhanced anxiolytic activity (\n                    <jats:italic>p<\/jats:italic>\n                    &lt;\u20090.001) in all behavioral models. It also moderately reduced immobility in the FST and TST (\n                    <jats:italic>p<\/jats:italic>\n                    &lt;\u20090.01). Furthermore, MESG significantly suppressed locomotor activity in the OFT and HCT (\n                    <jats:italic>p<\/jats:italic>\n                    &lt;\u20090.001), indicating strong sedative action. The same dose effectively lowered rectal temperature in the fever model (\n                    <jats:italic>p<\/jats:italic>\n                    &lt;\u20090.05). Computational docking scores, which ranged from \u22122.6 to \u221210\u2009kcal\/mol, further supported these biological effects. In conclusion,\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>S. grande<\/jats:italic>\n                    <\/jats:styled-content>\n                    shows considerable promise as a source of therapeutic agents for treating anxiety, depression, insomnia, and fever.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.71088","type":"journal-article","created":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T13:59:24Z","timestamp":1760795964000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Exploring the Neuropharmacological and Antipyretic Effects of\n                    <i>Syzygium grande<\/i>\n                    (Wight) Walp. Methanolic Leaf Extract: An In\u00a0Vivo and Computational Study Incorporating\n                    <scp>GC<\/scp>\n                    \u2013\n                    <scp>MS\/MS Analysis<\/scp>"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1926-6407","authenticated-orcid":false,"given":"Md. Jahirul Islam","family":"Mamun","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Faculty of Biological Sciences University of Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5427-9603","authenticated-orcid":false,"given":"Sifatul Islam","family":"Mizan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Biological Sciences University of Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4169-899X","authenticated-orcid":false,"given":"Mahathir","family":"Mohammad","sequence":"additional","affiliation":[{"name":"Department of Chemistry Chittagong University of Engineering and Technology  Chattogram Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1945-6598","authenticated-orcid":false,"given":"Md. Liakot","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Biological Sciences University of Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3108-8477","authenticated-orcid":false,"given":"Md. 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