{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T13:06:25Z","timestamp":1790168785213,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T00:00:00Z","timestamp":1761782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T00:00:00Z","timestamp":1761782400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2024MH183"],"award-info":[{"award-number":["ZR2024MH183"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173575"],"award-info":[{"award-number":["82173575"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2242023 k30022"],"award-info":[{"award-number":["2242023 k30022"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Traditional dietary assessment methods such as 24\u2010h dietary recall methods are not accurate enough, and the biomarkers to objectively evaluate food consumption have become attractive recently. Soy isoflavones are a typical plant\u2010based estrogen that helps to slow menopause symptoms, helping to lower cholesterol levels and reduce the risk of arteriosclerosis, and studies have shown a significant correlation between urinary isoflavones excretion and soy intake, which can be used as a useful biomarker. Because of the complex urine sample matrix and the large range of isoflavone concentration, it is vital to develop a new detection method to decrease the impurities interference and increase the target concentration for accurate detection of urine isoflavones. In this study, a few types of nanofibers were prepared and utilized as solid\u2010phase extraction adsorbents for sample pretreatment, and the homemade packed\u2010nanofiber solid\u2010phase extraction columns were chosen to purify the matrix and concentrate the analytes. A new method for rapid detection of soybean isoflavones in urine on the basis of packed\u2010fiber solid\u2010phase extraction combined with ultraviolet spectrophotometer was established, which provides an efficient reference for assessment of individual dietary intake.<\/jats:p>","DOI":"10.1002\/fsn3.71116","type":"journal-article","created":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T11:49:06Z","timestamp":1761824946000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A New Detection Method for the Biomarkers of Soybean Isoflavones in Human Urine on the Basis of Packed\u2010Fiber Solid\u2010Phase Extraction"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5088-2994","authenticated-orcid":false,"given":"Lanling","family":"Chu","sequence":"first","affiliation":[{"name":"State Key Laboratory for Development and Utilization of Forest Food Resources Nanjing Forestry University  Nanjing PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqi","family":"Dai","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Development and Utilization of Forest Food Resources Nanjing Forestry University  Nanjing PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghai","family":"Hu","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Development and Utilization of Forest Food Resources Nanjing Forestry University  Nanjing PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erzheng","family":"Su","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Development and Utilization of Forest Food Resources Nanjing Forestry University  Nanjing PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Qi","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Development and Utilization of Forest Food Resources Nanjing Forestry University  Nanjing PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoman","family":"Jiang","sequence":"additional","affiliation":[{"name":"Yantai Key Laboratory of Special Medical Food (Preparatory), School of Food and Biological Engineering Yantai Institute of Technology  Yantai PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anni","family":"Fu","sequence":"additional","affiliation":[{"name":"Yantai Key Laboratory of Special Medical Food (Preparatory), School of Food and Biological Engineering Yantai Institute of Technology  Yantai PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Jiang","sequence":"additional","affiliation":[{"name":"Yantai Key Laboratory of Special Medical Food (Preparatory), School of Food and Biological Engineering Yantai Institute of Technology  Yantai PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejun","family":"Kang","sequence":"additional","affiliation":[{"name":"School of Biological Science and Medical Engineering Southeast University  Nanjing PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/plants11060741"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/54.6.1093"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods11020232"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2024.142313"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/chrsci\/49.10.764"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.38212\/2224\u20106614.2307"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2020.115752"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635589909514752"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1039\/d1ay00793a"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2022.128494"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.975718"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scib.2022.01.011"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.9755\/ejfa.2023.3131"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/0962280219837698"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408347.2017.1396885"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408347.2021.1947771"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.4162\/nrp.2021.15.1.1"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.9b01312"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2007.01.021"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.17221\/138\/2010\u2010CJFS"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmacrolett.0c00829"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12937\u2010024\u201000941\u20105"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2024.117912"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2022.0100"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods13040628"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2020.127097"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1039\/d3gc02347h"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.greeac.2024.100126"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12161\u2010021\u201002120\u20102"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.9b08107"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20103\u2010030\u201093337\u20101_17"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2022.2163372"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1039\/c1nr10304k"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2015.09.029"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2021.129829"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2014.08.004"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s42341\u2010021\u201000342\u2010z"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15102352"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwac024"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.2832"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.microc.2022.107824"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1872\u20102040(06)60030\u20103"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1515\/biol\u20102022\u20100560"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1039\/d2ay01753a"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2020.561010"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2022.116553"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seppur.2023.125411"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2021.130409"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00894\u2010019\u20104090\u20108"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2020.461822"}],"container-title":["Food Science &amp; Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/fsn3.71116","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/fsn3.71116","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/fsn3.71116","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T12:36:27Z","timestamp":1790166987000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/fsn3.71116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,30]]},"references-count":50,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1002\/fsn3.71116"],"URL":"https:\/\/doi.org\/10.1002\/fsn3.71116","archive":["Portico"],"relation":{},"ISSN":["2048-7177","2048-7177"],"issn-type":[{"value":"2048-7177","type":"print"},{"value":"2048-7177","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,30]]},"assertion":[{"value":"2025-03-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71116"}}