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These include parsley, celery, chamomile, and snow lotus. Apigenin demonstrates a broad spectrum of biological activities, such as anti\u2010inflammatory, antioxidant, anti\u2010cancer, neuroprotective, and antidiabetic effects. Consequently, many scientists have endeavored to develop it as a drug. Nevertheless, there are no commercially available or clinically used drugs containing apigenin, primarily because of its poor water and fat solubility. In this study, a topical administration approach of apigenin was employed to treat skin diseases, aiming to overcome the issue of low bioavailability. Based on the target prediction results, the top 10 targets suggest that androgenetic alopecia (AGA) is a potential target disease. After 28\u2009days of treatment in testosterone\u2010induced AGA mice, the hair growth status was comparable to that in the minoxidil group and the normal group, and was significantly better than that in the model group. The mRNA level expression in the serum indicated that apigenin might promote hair growth through the Wnt signaling pathway. The docking study revealed that CDK5 is the most likely target of apigenin for treating AGA. This study verified that topical administration of apigenin is a viable strategy for drug development.<\/jats:p>","DOI":"10.1002\/fsn3.71155","type":"journal-article","created":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T11:55:33Z","timestamp":1764244533000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Overcoming the Low Bioavailability of Apigenin: The Therapeutic Efficacy for Androgenetic Alopecia Through Topical Administration"],"prefix":"10.1002","volume":"13","author":[{"given":"Yanxi","family":"Peng","sequence":"first","affiliation":[{"name":"School of Public Health Xiangnan University  Chenzhou Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences Xiangnan University  Chenzhou Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqing","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences Xiangnan University  Chenzhou Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dane","family":"Huang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Anti\u2010Infective Drug Discovery and Development, School of Pharmaceutical Sciences Sun Yat\u2010Sen University  Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Research and Development in Traditional Chinese Medicine  Guangzhou China"},{"name":"Guangdong Provincial Second Hospital of Traditional Chinese Medicine (Guangdong Provincial Engineering Technology Research Institute of Traditional Chinese Medicine)  Guangzhou China"},{"name":"The Fifth Clinical College of Guangzhou University of Chinese Medicine Guangzhou University of Chinese Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5615-0022","authenticated-orcid":false,"given":"Chao","family":"Zhao","sequence":"additional","affiliation":[{"name":"College of Pharmacology Xiangnan University  Chenzhou Hunan China"},{"name":"Research and Development Department, Cinaneo Pharmaceuticals, Ltd.  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