{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T13:06:05Z","timestamp":1790168765196,"version":"4.1.0"},"reference-count":66,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Arenga porphyrocarpa<\/jats:italic>\n                    palm tree roots and buds are used to treat urinary incontinence, fever, appetite loss, and as a diuretic. Our study aimed to evaluate the neuropharmacological, antioxidant, cytotoxic, and thrombolytic potentials of\n                    <jats:italic>A. porphyrocarpa<\/jats:italic>\n                    leaf and stem extracts through in\u00a0vivo, in\u00a0vitro and in silico studies. Different fractions of\n                    <jats:italic>A. porphyrocarpa<\/jats:italic>\n                    leaves and stems were investigated for anxiolytic and anti\u2010depressant efficacy through EPM and HBT and TST and FST tests. The anti\u2010oxidant assessment was assessed by using DPPH and reducing power assays, while thrombolytic efficacy was analyzed by clot lysis technique. Computational methods like in silico molecular docking, pass prediction and ADME\/T were applied to evaluate several pharmacological properties of 15 selected compounds from GC\u2013MS analysis of plant extract. Both doses of the plant extract fractions (200 and 400\u2009mg\/kg) showed dose\u2010dependent anxiolytic and antidepressant\u2010like effects in mice, with the 400\u2009mg\/kg dose found to have highly significant (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) effects. Among the fractions, the chloroform fraction of\n                    <jats:italic>A. porphyrocarpa<\/jats:italic>\n                    leaves (CFAPL) exhibited the strongest antioxidant activity, as indicated by its DPPH scavenging potential (IC\u2085\u2080\u2009=\u2009128.94\u2009\u03bcg\/mL), and also demonstrated the most effective clot lysis. In silico analysis further revealed that several bioactive compounds had strong binding affinities to target proteins, including isobutyric acid 2,2,2\u2010trichloroethyl ester (anxiolytic activity), 2\u2010cyclobutene\u20101\u2010carboxamide (antidepressant activity), 2\u2010pyridinecarboxylic acid (antioxidant activity), propionic acid 3\u2010(isobutylthio)\u2010 (cytotoxic), and 2\u2010propanone 1\u2010hydroxy\u2010 (thrombolytic activity). Ongoing investigations indicate that\n                    <jats:italic>A. porphyrocarpa<\/jats:italic>\n                    is a promising candidate for the treatment of neuropsychiatric and cardiovascular disorders; however, further cytotoxicity studies and confirmation of the specific bioactive compounds responsible for its biological activities are needed.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.71178","type":"journal-article","created":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T11:21:49Z","timestamp":1763551309000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Multimodal Pharmacological Assessment of\n                    <i>Arenga porphyrocarpa<\/i>\n                    Palm Leaves and Stems Extracts: Insights From In\u00a0Vivo, In\u00a0Vitro, and In Silico Approaches"],"prefix":"10.1002","volume":"13","author":[{"given":"Jahid Hasan","family":"Azad","sequence":"first","affiliation":[{"name":"Department of Pharmacy International Islamic University Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4976-897X","authenticated-orcid":false,"given":"Fowzul Islam","family":"Fahad","sequence":"additional","affiliation":[{"name":"Department of Pharmacy International Islamic University Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koushik","family":"Barua","sequence":"additional","affiliation":[{"name":"Department of Pharmacy International Islamic University Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. M. Asadul Karim","family":"Azad","sequence":"additional","affiliation":[{"name":"Department of Pharmacy International Islamic University Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1831-2278","authenticated-orcid":false,"given":"Safaet","family":"Alam","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy University of Dhaka  Dhaka Bangladesh"},{"name":"Chemical Research Division, BCSIR Dhaka Laboratories Bangladesh Council of Scientific and Industrial Research  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahmida Tasnim","family":"Richi","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy University of Dhaka  Dhaka Bangladesh"},{"name":"Department of Pharmacy University of Asia Pacific  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2804-1944","authenticated-orcid":false,"given":"Rasel","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy International Islamic University Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed Mohammed","family":"Tareq","sequence":"additional","affiliation":[{"name":"Department of Pharmacy International Islamic University Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Mutasim","family":"Billah","sequence":"additional","affiliation":[{"name":"Department of Pharmacy International Islamic University Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Sohel","family":"Rana","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Jahangirnagar University  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4021-106X","authenticated-orcid":false,"given":"Mohammad Nazmul","family":"Islam","sequence":"additional","affiliation":[{"name":"Department of Pharmacy International Islamic University Chittagong  Chittagong Bangladesh"},{"name":"Department of Pharmacy Jahangirnagar University  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,19]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2013.03.046"},{"issue":"4","key":"e_1_2_11_3_1","article-title":"Comparative Study of Piper Sylvaticum Roxb. 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