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JI017 is a recently optimized multi\u2010herbal formula composed of\n                    <jats:italic>Angelica gigas<\/jats:italic>\n                    ,\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Zingiber officinale<\/jats:italic>\n                    <\/jats:styled-content>\n                    , and processed\n                    <jats:italic>Aconitum carmichaeli<\/jats:italic>\n                    . Clinical records of these three herbs indicate their potentially synergistic anti\u2010obesity effects. This study was conducted to verify the effects of JI017 in an animal model of obesity\u2010associated NAFLD. The effect of JI017 on glucose metabolism, white adipose tissue (WAT) adipogenesis, brown adipose tissue (BAT) thermogenesis, liver oxidative stress, and gut microbiota composition was assessed. The results showed that JI017 improved glucose sensitivity, reduced WAT mass by suppressing PPAR\u03b3 and C\/EBP\u03b1 expression, and increased BAT thermogenesis through upregulation of UCP1 and PGC\u20101\u03b1. Additionally, JI017 reduced liver oxidative stress by increasing HO\u20101 and NRF2 expression and modulated the gut microbiota by restoring the\n                    <jats:italic>Firmicutes<\/jats:italic>\n                    \/\n                    <jats:italic>Bacteroidetes<\/jats:italic>\n                    ratio. These findings on the multi\u2010targeted effects of JI017 suggest its potential as a promising therapeutic approach for metabolic diseases including NAFLD.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.71199","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T09:25:34Z","timestamp":1764062734000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Herbal Combination of\n                    <i>Angelica gigas<\/i>\n                    ,\n                    <i>Zingiber officinale<\/i>\n                    , and\n                    <i>Aconitum carmichaeli<\/i>\n                    Alleviates High Fat Diet\u2010Induced Non\u2010Alcoholic Fatty Liver Disease in Mice Through\n                    <scp>NRF2<\/scp>\n                    \u2010Mediated Regulation of Adipogenesis and Non\u2010Shivering 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