{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:15:02Z","timestamp":1791587702372,"version":"4.3.4"},"reference-count":245,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T00:00:00Z","timestamp":1764201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T00:00:00Z","timestamp":1764201600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Selenium, an essential trace element in the human body, is present in the form of selenocysteine (Sec) within 25 selenoproteins, including selenoprotein N, selenoprotein P, and glutathione peroxidases (GPXs). An increasing number of studies have shown that selenoproteins resulting from selenium metabolism exert a significant effect on diverse immune cells. For instance, both selenoprotein K and GPX4 are intricately involved in the initiation and resolution of pro\u2010inflammatory responses in granulocytes (PMN). The function of dendritic cells (DCs) exhibits a specific association with the expression of selenoproteins. Methionine sulfoxide reductase B1 (MSRB1) can facilitate lipopolysaccharide (LPS) in stimulating bone marrow\u2010derived macrophages (BMDM), induce the production of anti\u2010inflammatory cytokines interleukin\u201010 (IL\u201010) and interleukin\u20101 receptor antagonist (IL\u20101RA), and thereby partake in immune activities. The roles of selenoproteins in immune cells underscore their significance and complexity in the overall physiological process. In particular, their involvement in tumor immunity warrants in\u2010depth exploration. In solid tumors, the process by which cancer cells generate selenoproteins, especially GPX4, through selenium metabolism constructs a defense mechanism against ferroptosis. This process is highly reliant on the capacity of cancer cells to take up selenium independently, as well as the activation of selenium metabolic pathways such as the trans\u2010selenation pathway and the breakdown of inorganic selenium compounds. In the autophagy mediated by copper and erastin (a ferroptosis inducer), the autophagy receptors TAX1BP1 and SQSTM1 can promote the degradation of GPX4, effectively reducing the resistance of cancer cells to ferroptosis. This distinctive mechanism has opened up a novel perspective for research and offered potential therapeutic targets in the field of cancer treatment. In this review, we conduct a comprehensive and in\u2010depth analysis of the roles played by selenoproteins derived from selenium metabolism in the regulation of immune cells associated with immune diseases. Moreover, we elaborate in detail on the effects of GPX4 in relation to ferroptosis in solid tumors under the influence of autophagy\u2010mediated immunomodulation.<\/jats:p>","DOI":"10.1002\/fsn3.71230","type":"journal-article","created":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T07:31:12Z","timestamp":1764315072000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Metabolic Functions and Mechanisms of Selenium, Selenocysteine, and\n                    <scp>GPX4<\/scp>\n                    Mediated Immune Regulation Through Autophagy in Solid Tumors"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5672-9763","authenticated-orcid":false,"given":"Liang","family":"Yang","sequence":"first","affiliation":[{"name":"School of Chemistry and Pharmaceutical Engineering Hefei Normal University  Hefei China"},{"name":"Anhui Zhongzhi Technology Co., Ltd  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Jiang","sequence":"additional","affiliation":[{"name":"School of Chemistry and Pharmaceutical Engineering Hefei Normal University  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyue","family":"Wu","sequence":"additional","affiliation":[{"name":"Anhui Zhongzhi Technology Co., Ltd  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinnan","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Chemistry and Pharmaceutical Engineering Hefei Normal University  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyue","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Chemistry and Pharmaceutical Engineering Hefei Normal University  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingfeng","family":"Hong","sequence":"additional","affiliation":[{"name":"School of Chemistry and Pharmaceutical Engineering Hefei Normal University  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zheng","sequence":"additional","affiliation":[{"name":"School of Chemistry and Pharmaceutical Engineering Hefei Normal University  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinmiao","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Chemistry and Pharmaceutical Engineering Hefei Normal University  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,27]]},"reference":[{"key":"e_1_2_13_2_1","first-page":"885","article-title":"Mitochondria and Reactive Oxygen Species","volume":"53","author":"Addabbo F.","year":"2009","journal-title":"Hypertens. Dallas Tex 1979"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.202318014"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2018.212977"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells13121001"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201300543"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201701654"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2005.15.210"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2010.02.032"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1042\/EBC20190051"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/133.5.1457S"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/57.2.236S"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu10091203"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2022.101824"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.2001.2642"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11020251"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI76099"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu7053094"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2018.01.010"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0079167"},{"key":"e_1_2_13_21_1","first-page":"94","article-title":"Selenium: Its Role as Antioxidant in Human Health","volume":"13","author":"Bingheng C.","year":"2008","journal-title":"Environmental Health and Preventive Medicine"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27196613"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.20.11761"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222111906"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1515\/BC.2006.166"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2009.03.006"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms251810101"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2981"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-020-0224-7"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-012-0896-x"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.102703"},{"key":"e_1_2_13_32_1","first-page":"320","article-title":"An Original Discovery: Selenium Deficiency and Keshan Disease (An Endemic Heart Disease)","volume":"21","author":"Chen J.","year":"2012","journal-title":"Asia Pacific Journal of Clinical Nutrition"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.680090"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-020-00462-0"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2022.2059170"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1177\/09636897211053203"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2003847117"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2021.102003"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes14091674"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2010.00926.x"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2020.1714209"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvaa115"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.571844"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-24-3478"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-021-02889-5"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2022.5410"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-014-0076-7"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.03.042"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-018-0201-5"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2023.04.005"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2022.102183"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)34734-3"},{"key":"e_1_2_13_53_1","first-page":"6497","article-title":"Optimising Selenium for Modulation of Cancer Treatments","volume":"37","author":"Evans S. O.","year":"2017","journal-title":"Anticancer Research"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2010.3275"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-021-02997-4"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2022.05.003"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom13030486"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.21168"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2018.03.001"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2006.02.005"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2014.04.003"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-1482.19585"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2020.144884"},{"key":"e_1_2_13_64_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2018.7594"},{"key":"e_1_2_13_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.27842"},{"key":"e_1_2_13_66_1","doi-asserted-by":"publisher","DOI":"10.1089\/15230860152409004"},{"key":"e_1_2_13_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41417-025-00927-3"},{"key":"e_1_2_13_68_1","article-title":"Evaluation of the Selenotranscriptome Expression in Two Hepatocellular Carcinoma Cell Lines","volume":"2015","author":"Guariniello S.","year":"2015","journal-title":"Analytical Cellular Pathology (Amsterdam)"},{"key":"e_1_2_13_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2011.10.013"},{"key":"e_1_2_13_70_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-019-01771-x"},{"key":"e_1_2_13_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2023.127235"},{"key":"e_1_2_13_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-023-00564-1"},{"key":"e_1_2_13_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-020-00690-x"},{"key":"e_1_2_13_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2019.04.002"},{"key":"e_1_2_13_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.09.076"},{"key":"e_1_2_13_76_1","article-title":"GPx3 Dysregulation Impacts Adipose Tissue Insulin Receptor Expression and Sensitivity","volume":"5","author":"Hauffe R.","year":"2020","journal-title":"JCI Insight"},{"key":"e_1_2_13_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2011.08.032"},{"key":"e_1_2_13_78_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/5287971"},{"key":"e_1_2_13_79_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-025-03356-4"},{"key":"e_1_2_13_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.07.004"},{"key":"e_1_2_13_81_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202404073"},{"key":"e_1_2_13_82_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2011.4145"},{"key":"e_1_2_13_83_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10534-021-00347-4"},{"key":"e_1_2_13_84_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2016.5464"},{"key":"e_1_2_13_85_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.006288"},{"key":"e_1_2_13_86_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-021-02716-z"},{"key":"e_1_2_13_87_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules21050609"},{"key":"e_1_2_13_88_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-024-04245-x"},{"key":"e_1_2_13_89_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M034603"},{"key":"e_1_2_13_90_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-22565-7"},{"key":"e_1_2_13_91_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222111844"},{"key":"e_1_2_13_92_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12061769"},{"key":"e_1_2_13_93_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.14100"},{"key":"e_1_2_13_94_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1083516"},{"key":"e_1_2_13_95_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00039.2013"},{"key":"e_1_2_13_96_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-016-0908-8"},{"key":"e_1_2_13_97_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-05230-2"},{"key":"e_1_2_13_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2022.109452"},{"key":"e_1_2_13_99_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nutr.27.061406.093716"},{"key":"e_1_2_13_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2022.01.005"},{"key":"e_1_2_13_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2018.01.151"},{"key":"e_1_2_13_102_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11427-023-2621-7"},{"key":"e_1_2_13_103_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-021-00993-3"},{"key":"e_1_2_13_104_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-019-0299-4"},{"key":"e_1_2_13_105_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-022-01033-3"},{"key":"e_1_2_13_106_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.032839"},{"key":"e_1_2_13_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2018.04.006"},{"key":"e_1_2_13_108_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-023-01512-7"},{"key":"e_1_2_13_109_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2022.2111635"},{"key":"e_1_2_13_110_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-022-04155-y"},{"key":"e_1_2_13_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2023.188890"},{"key":"e_1_2_13_112_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-88355-9"},{"key":"e_1_2_13_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.112436"},{"key":"e_1_2_13_114_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2010.3586"},{"key":"e_1_2_13_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2020.11.006"},{"key":"e_1_2_13_116_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222011174"},{"key":"e_1_2_13_117_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-022-01212-0"},{"key":"e_1_2_13_118_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2009.495"},{"key":"e_1_2_13_119_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-019-01774-8"},{"key":"e_1_2_13_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2018.03.035"},{"key":"e_1_2_13_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2023.127331"},{"key":"e_1_2_13_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2012.11.022"},{"key":"e_1_2_13_123_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-59381-2"},{"key":"e_1_2_13_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2024.103114"},{"key":"e_1_2_13_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2022.102571"},{"key":"e_1_2_13_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2011.07.034"},{"key":"e_1_2_13_127_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng713"},{"key":"e_1_2_13_128_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2448"},{"key":"e_1_2_13_129_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-024-02526-9"},{"key":"e_1_2_13_130_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-23-2194"},{"key":"e_1_2_13_131_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43018-024-00844-8"},{"key":"e_1_2_13_132_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9SC04616J"},{"key":"e_1_2_13_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2021.06.051"},{"key":"e_1_2_13_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2008.09.008"},{"key":"e_1_2_13_135_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.571372"},{"key":"e_1_2_13_136_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12111906"},{"key":"e_1_2_13_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2022.109376"},{"key":"e_1_2_13_138_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-52718-0"},{"key":"e_1_2_13_139_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0902204106"},{"key":"e_1_2_13_140_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2007.1528"},{"key":"e_1_2_13_141_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1147414"},{"key":"e_1_2_13_142_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-16-3480"},{"key":"e_1_2_13_143_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.471235"},{"key":"e_1_2_13_144_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6MB00469E"},{"key":"e_1_2_13_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2016.12.004"},{"key":"e_1_2_13_146_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2019.7931"},{"key":"e_1_2_13_147_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI171885"},{"key":"e_1_2_13_148_1","doi-asserted-by":"publisher","DOI":"10.1080\/10409238.2020.1717430"},{"key":"e_1_2_13_149_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-10-1026"},{"key":"e_1_2_13_150_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114508939830"},{"key":"e_1_2_13_151_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114508922522"},{"key":"e_1_2_13_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61452-9"},{"key":"e_1_2_13_153_1","doi-asserted-by":"publisher","DOI":"10.1007\/s42000-019-00125-5"},{"key":"e_1_2_13_154_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16132382"},{"key":"e_1_2_13_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2021.07.013"},{"key":"e_1_2_13_156_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.6b00031"},{"key":"e_1_2_13_157_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2107266119"},{"key":"e_1_2_13_158_1","doi-asserted-by":"publisher","DOI":"10.1039\/C3MT00185G"},{"key":"e_1_2_13_159_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(02)47020-6"},{"key":"e_1_2_13_160_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11101868"},{"key":"e_1_2_13_161_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2024.01.036"},{"key":"e_1_2_13_162_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11102523"},{"key":"e_1_2_13_163_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2018.0480"},{"key":"e_1_2_13_164_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox8050120"},{"key":"e_1_2_13_165_1","doi-asserted-by":"publisher","DOI":"10.1007\/s42000-019-00150-4"},{"key":"e_1_2_13_166_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22168532"},{"key":"e_1_2_13_167_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2022.08.022"},{"key":"e_1_2_13_168_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2006.tb00616.x"},{"key":"e_1_2_13_169_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2018.09.014"},{"key":"e_1_2_13_170_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2015.05.024"},{"key":"e_1_2_13_171_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-018-2595-6"},{"key":"e_1_2_13_172_1","doi-asserted-by":"publisher","DOI":"10.1261\/rna.043463.113"},{"key":"e_1_2_13_173_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-019-0326-7"},{"key":"e_1_2_13_174_1","doi-asserted-by":"publisher","DOI":"10.1039\/C1MB05272A"},{"key":"e_1_2_13_175_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi400462j"},{"key":"e_1_2_13_176_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2018.02.030"},{"key":"e_1_2_13_177_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8MT00041G"},{"key":"e_1_2_13_178_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-020-0613-y"},{"key":"e_1_2_13_179_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.09.021"},{"key":"e_1_2_13_180_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu7031494"},{"key":"e_1_2_13_181_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gim.2024.101280"},{"key":"e_1_2_13_182_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110108"},{"key":"e_1_2_13_183_1","doi-asserted-by":"publisher","DOI":"10.1080\/02652030210153578"},{"key":"e_1_2_13_184_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1306241110"},{"key":"e_1_2_13_185_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-010-0811-7"},{"key":"e_1_2_13_186_1","first-page":"4","article-title":"Norms of Physiological Requirements in Energy and Nutrients in Various Groups of Population in Russian Federation","volume":"78","author":"Tutel'ian V. A.","year":"2009","journal-title":"Voprosy Pitaniia"},{"key":"e_1_2_13_187_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.285.5432.1393"},{"key":"e_1_2_13_188_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2760(82)90150-3"},{"key":"e_1_2_13_189_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2017-00666"},{"key":"e_1_2_13_190_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22157798"},{"key":"e_1_2_13_191_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22126614"},{"key":"e_1_2_13_192_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1002878"},{"key":"e_1_2_13_193_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40572-018-0213-0"},{"key":"e_1_2_13_194_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells12182210"},{"key":"e_1_2_13_195_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2019.02.028"},{"key":"e_1_2_13_196_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.6.1859"},{"key":"e_1_2_13_197_1","first-page":"473","article-title":"Cystathionine\u2010\u03b3\u2010Lyase Promotes the Metastasis of Breast Cancer via the VEGF Signaling Pathway","volume":"55","author":"Wang L.","year":"2019","journal-title":"International Journal of Oncology"},{"key":"e_1_2_13_198_1","first-page":"427","article-title":"I157172, a Novel Inhibitor of Cystathionine \u03b3\u2010Lyase, Inhibits Growth and Migration of Breast Cancer Cells via SIRT1\u2010Mediated Deacetylation of STAT3","volume":"41","author":"Wang L.","year":"2019","journal-title":"Oncology Reports"},{"key":"e_1_2_13_199_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-03718-4"},{"key":"e_1_2_13_200_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-025-02947-0"},{"key":"e_1_2_13_201_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22126562"},{"key":"e_1_2_13_202_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2201899119"},{"key":"e_1_2_13_203_1","article-title":"The Selenoprotein Glutathione Peroxidase 4: From Molecular Mechanisms to Novel Therapeutic Opportunities","volume":"10","author":"Weaver K.","year":"2022","journal-title":"Biomedicine"},{"key":"e_1_2_13_204_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3cs60272a"},{"key":"e_1_2_13_205_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00000666"},{"key":"e_1_2_13_206_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-060815-014442"},{"key":"e_1_2_13_207_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2016.116"},{"key":"e_1_2_13_208_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2019.104360"},{"key":"e_1_2_13_209_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12034"},{"key":"e_1_2_13_210_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST20220682"},{"key":"e_1_2_13_211_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11071264"},{"key":"e_1_2_13_212_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0FO03067H"},{"key":"e_1_2_13_213_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2015.158"},{"key":"e_1_2_13_214_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2023.2218764"},{"key":"e_1_2_13_215_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109235"},{"key":"e_1_2_13_216_1","first-page":"316","article-title":"Further Investigation on the Role of Selenium Deficiency in the Aetiology and Pathogenesis of Keshan Disease","volume":"10","author":"Xu G. L.","year":"1997","journal-title":"Biomedical and Environmental Sciences"},{"key":"e_1_2_13_217_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2023.2165323"},{"key":"e_1_2_13_218_1","first-page":"2693","article-title":"Expression of Selenium\u2010Containing Proteins in Human Colon Carcinoma Tissue","volume":"31","author":"Yagublu V.","year":"2011","journal-title":"Anticancer Research"},{"key":"e_1_2_13_219_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-014-0111-8"},{"key":"e_1_2_13_220_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbin.10644"},{"key":"e_1_2_13_221_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.202774"},{"key":"e_1_2_13_222_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-020-02842-y"},{"key":"e_1_2_13_223_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2014.10.014"},{"key":"e_1_2_13_224_1","doi-asserted-by":"publisher","DOI":"10.1186\/2050-7771-2-1"},{"key":"e_1_2_13_225_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.12.010"},{"key":"e_1_2_13_226_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2013.01.007"},{"key":"e_1_2_13_227_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2022.e12214"},{"key":"e_1_2_13_228_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02656"},{"key":"e_1_2_13_229_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-10991-7"},{"key":"e_1_2_13_230_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.002278"},{"key":"e_1_2_13_231_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.20057"},{"key":"e_1_2_13_232_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2020.07.006"},{"key":"e_1_2_13_233_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-017-0585-8"},{"key":"e_1_2_13_234_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-022-00939-8"},{"key":"e_1_2_13_235_1","doi-asserted-by":"publisher","DOI":"10.1111\/omi.12252"},{"key":"e_1_2_13_236_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagrm.2022.194814"},{"key":"e_1_2_13_237_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom13050799"},{"key":"e_1_2_13_238_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S328222"},{"key":"e_1_2_13_239_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08780"},{"key":"e_1_2_13_240_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.116512"},{"key":"e_1_2_13_241_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2020.08.011"},{"key":"e_1_2_13_242_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-015-0323-6"},{"key":"e_1_2_13_243_1","doi-asserted-by":"publisher","DOI":"10.1089\/gtmb.2021.0123"},{"key":"e_1_2_13_244_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-020-02477-1"},{"key":"e_1_2_13_245_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/3205125"},{"key":"e_1_2_13_246_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14153133"}],"container-title":["Food Science &amp; Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/fsn3.71230","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/fsn3.71230","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/fsn3.71230","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T13:40:53Z","timestamp":1771422053000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/fsn3.71230"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,27]]},"references-count":245,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/fsn3.71230"],"URL":"https:\/\/doi.org\/10.1002\/fsn3.71230","archive":["Portico"],"relation":{},"ISSN":["2048-7177","2048-7177"],"issn-type":[{"value":"2048-7177","type":"print"},{"value":"2048-7177","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,27]]},"assertion":[{"value":"2025-03-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71230"}}