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In this context, we sought to study the efficacy of quinoa in a nonalcoholic fatty liver disease (NAFLD) mouse model and its underlying mechanism of action. Male ICR mice were fed a high\u2010fat diet for 12\u2009weeks to establish a NAFLD model, followed by 6\u2009weeks of quinoa intervention. The mechanism by which quinoa improves NAFLD was explored using network pharmacology analysis and transcriptome sequencing analysis. Finally, combined with in\u00a0vivo experiments for verification. Quinoa significantly improved liver damage, abnormal glucose and lipid metabolism, and insulin resistance in NAFLD mice. The results of network pharmacology and transcriptomics indicate that the Ras\u2010PLD signaling pathway and autophagy are key pathways. Quinoa significantly regulates the expression of Ras, Raf, Mek, Erk, and autophagy\u2010related proteins in liver tissue. Meanwhile, quinoa regulates the expression of HNF4A, ACOX2, and glucagon in the liver and pancreas. Our results suggest that quinoa may improve NAFLD by inhibiting the Ras\u2010PLD signaling pathway and activating autophagy, regulating glucose and lipid metabolism and insulin resistance.<\/jats:p>","DOI":"10.1002\/fsn3.71233","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T09:02:07Z","timestamp":1764061327000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Quinoa Improves Non\u2010Alcoholic Fatty Liver Disease by Regulating the Ras\u2010\n                    <scp>PLD<\/scp>\n                    Pathway to Activate Autophagy"],"prefix":"10.1002","volume":"13","author":[{"given":"Yuelin","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Traditional Chinese Medicine Beijing University of Chinese Medicine  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengting","family":"Liang","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine Xinjiang Medical University  Xinjiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaxian","family":"Liu","sequence":"additional","affiliation":[{"name":"Zhongli Science and Technology Limited Company  Beijing China"},{"name":"Gansu Pure High\u2010Land Agricultural Science and Technology Limited Company  Lanzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianjie","family":"Zhen","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine Beijing University of Chinese Medicine  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruijie","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine Beijing University of Chinese Medicine  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohong","family":"Luo","sequence":"additional","affiliation":[{"name":"Xinjiang Tianrun Dairy Co., Ltd.  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