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Conventional treatments like antimuscarinic drugs show low adherence due to limited efficacy and side effects. This study explores the effects of natural supplementation with\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Angelica archangelica<\/jats:italic>\n                    <\/jats:styled-content>\n                    (AA) leaf extract on OAB symptoms, focusing on daytime voids, nocturia, and urgency. A pilot study with a randomized, triple\u2010blind, controlled trial design, registered on\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                    (NCT04357223), was conducted with 143 participants assigned to AA (SUP) or placebo (PLA) groups in a 1.75:1 ratio over 6\u2009weeks. Adults aged 18\u201375 with specific OAB symptoms were included. Data were securely managed via the RedCap platform. OAB symptomatology was assessed following the recommended tools and scales according to the Spanish Association of Urology guidelines: A 3\u2010day voiding diary (3\u2010dVD) and the International Prostate Symptom Score (IPSS). Additionally, the IPSS total score and IPSS storage subscore were measured. Statistical analysis was performed by SPSS, R, and Python. The Wilcoxon test was used to analyze pre\u2010to\u2010post differences, and linear mixed model analysis for group\u2010by\u2010time interactions. SUP showed significant improvements in daytime voids (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.004; \u03b7\n                    <jats:sup>2<\/jats:sup>\n                    <jats:sub>g<\/jats:sub>\n                    \u2009=\u20090.07), IPSS storage subscore (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.025; \u03b7\n                    <jats:sup>2<\/jats:sup>\n                    <jats:sub>g<\/jats:sub>\n                    \u2009=\u20090.05), and QoL (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001; \u03b7\n                    <jats:sup>2<\/jats:sup>\n                    <jats:sub>g<\/jats:sub>\n                    \u2009=\u20090.12), while a nearly significant improvement in nocturia was observed through IPSS results (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.069; \u03b7\n                    <jats:sup>2<\/jats:sup>\n                    <jats:sub>g<\/jats:sub>\n                    \u2009=\u20090.03) compared with PLA. IPSS total score changes were clinically meaningful and higher in SUP (from 19.78 to 15.89) than in PLA (from 19.64 to 16.38). Adults with OAB syndrome significantly reduced daytime voids and IPSS storage subscore, improving QoL after AA supplementation for 6\u2009weeks. Positive effects on nocturia were also observed.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration:<\/jats:bold>\n                    ClinicalTrials.gov identifier: NCT04357223\n                  <\/jats:p>","DOI":"10.1002\/fsn3.71258","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T10:40:29Z","timestamp":1765190429000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of\n                    <scp>\n                      <i>Angelica archangelica<\/i>\n                    <\/scp>\n                    Extract on Overactive Bladder: A Pilot Randomized Controlled Trial"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4597-2888","authenticated-orcid":false,"given":"Jaime","family":"L\u00f3pez\u2010Seoane","sequence":"first","affiliation":[{"name":"ImFINE Research Group, Department of Health and Human Performance, Faculty of Physical Activity and Sport Sciences\u2010INEF Universidad Polit\u00e9cnica de Madrid  Madrid Spain"},{"name":"Red Espa\u00f1ola de Investigaci\u00f3n en Ejercicio F\u00edsico y Salud (EXERNET)  Zaragoza Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9498-4228","authenticated-orcid":false,"given":"Eva","family":"Gesteiro","sequence":"additional","affiliation":[{"name":"ImFINE Research Group, Department of Health and Human Performance, Faculty of Physical Activity and Sport Sciences\u2010INEF Universidad Polit\u00e9cnica de Madrid  Madrid Spain"},{"name":"Red Espa\u00f1ola de Investigaci\u00f3n en Ejercicio F\u00edsico y Salud (EXERNET)  Zaragoza Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1852-4318","authenticated-orcid":false,"given":"Mar\u00eda Jos\u00e9","family":"Castro\u2010Alija","sequence":"additional","affiliation":[{"name":"Research Group on Assessment and Multidisciplinary Intervention in Health Care and Sustainable Lifestyles, Faculty of Nursing University of Valladolid  Valladolid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7234-5268","authenticated-orcid":false,"given":"Carlos","family":"Quesada\u2010Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"ImFINE Research Group, Department of Health and Human Performance, Faculty of Physical Activity and Sport Sciences\u2010INEF Universidad Polit\u00e9cnica de Madrid  Madrid Spain"},{"name":"Department of Mathematics Applied to Information and Communication Technologies Universidad Polit\u00e9cnica de Madrid  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7240-2082","authenticated-orcid":false,"given":"Margarita","family":"P\u00e9rez\u2010Ruiz","sequence":"additional","affiliation":[{"name":"ImFINE Research Group, Department of Health and Human Performance, Faculty of Physical Activity and Sport Sciences\u2010INEF Universidad Polit\u00e9cnica de Madrid  Madrid Spain"},{"name":"Red Espa\u00f1ola de Investigaci\u00f3n en Ejercicio F\u00edsico y Salud (EXERNET)  Zaragoza Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7757-3235","authenticated-orcid":false,"given":"Marcela","family":"Gonz\u00e1lez\u2010Gross","sequence":"additional","affiliation":[{"name":"ImFINE Research Group, Department of Health and Human Performance, Faculty of Physical Activity and Sport Sciences\u2010INEF Universidad Polit\u00e9cnica de Madrid  Madrid Spain"},{"name":"Red Espa\u00f1ola de Investigaci\u00f3n en Ejercicio F\u00edsico y Salud (EXERNET)  Zaragoza Spain"},{"name":"Department of Biomedical Research Center of Pathophysiology of Obesity and Nutrition\u2010CIBERobn, Carlos III Health Institute  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,8]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.10052"},{"issue":"11","key":"e_1_2_13_3_1","first-page":"580","article-title":"Overactive Bladder Significantly Affects Quality of Life","volume":"6","author":"Abrams P.","year":"2000","journal-title":"American Journal of Managed Care"},{"key":"e_1_2_13_4_1","unstructured":"Adot Zurbano J. 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