{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T14:11:57Z","timestamp":1771423917925,"version":"3.50.1"},"reference-count":51,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:00:00Z","timestamp":1764288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:00:00Z","timestamp":1764288000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Mentha canadensis<\/jats:italic>\n                    <\/jats:styled-content>\n                    (wild Mint), a member of the Lamiaceae family, is traditionally used in herbal medicine, teas, and as a food additive in various regions, including Bangladesh. This research is designed to evaluate the hepatoprotective activity of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>M. canadensis<\/jats:italic>\n                    <\/jats:styled-content>\n                    leaf methanolic extract (MCLME) along with its antioxidant and anti\u2010inflammatory potential. The in\u00a0vitro antioxidant potential was evaluated through free radical scavenging assays such as ABTS and DPPH, as well as by a lipid peroxidation test. The anti\u2010inflammatory property of MCLME was examined using albumin denaturation and RBC membrane stabilization assays. Furthermore, qualitative and quantitative analyses of phytochemicals were carried out to investigate the basis of its therapeutic activity. A paracetamol\u2010induced hepatotoxicity Swiss\u2010albino mice model was used to assess the hepatoprotective activity of MCLME. Phytochemical analysis of MCLME confirmed the presence of alkaloids, flavonoids, triterpenoids, coumarins, saponins, and steroids, which may attribute to the extract's bioactivity. The extract also exhibited notable antioxidant and anti\u2010inflammatory activity. In a paracetamol\u2010induced hepatotoxicity mouse model, treatment with MCLME showed a significant (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001) reduction of elevated serum glutamate pyruvate transaminase (SGPT), serum glutamic\u2010oxaloacetic transaminase (SGOT), serum alkaline phosphatase (ALP), total bilirubin, and pro\u2010inflammatory cytokine IL\u20106. Also, histopathological analysis further confirmed the protective effects of MCLME on hepatic architecture. Additionally, MCLME restored the levels of hepatic glutathione (GSH), the key endogenous antioxidant, in treated mice. The hepatoprotective effects of the extract are comparable with the standard hepatoprotective agent, Silymarin (50\u2009mg\/kg body weight). Altogether, our findings indicate that\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>M. canadensis<\/jats:italic>\n                    <\/jats:styled-content>\n                    demonstrates significant hepatoprotective, antioxidative, and anti\u2010inflammatory characteristics, potentially serving as a natural alternative therapeutic agent for liver injury.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.71279","type":"journal-article","created":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T07:52:11Z","timestamp":1764402731000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Antioxidant and Hepatotoxicity Ameliorative Potential of\n                    <i>Mentha canadensis<\/i>\n                    Leaves Against Paracetamol\u2010Induced Hepatic Damage in Mice"],"prefix":"10.1002","volume":"13","author":[{"given":"Asma Ul Husna","family":"Biswas","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology University of Rajshahi  Rajshahi Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tasnima","family":"Kamal","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology University of Rajshahi  Rajshahi Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azmin","family":"Akter","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology University of Rajshahi  Rajshahi Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharmin","family":"Akter","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology University of Rajshahi  Rajshahi Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azadur Rahman","family":"Bhuiyan","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology University of Rajshahi  Rajshahi Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zinnat Ara","family":"Moni","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology University of Rajshahi  Rajshahi Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdul","family":"Auwal","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology University of Rajshahi  Rajshahi Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8454-6128","authenticated-orcid":false,"given":"Nitai","family":"Roy","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Patuakhali Science and Technology University  Patuakhali Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shakhawoat","family":"Hossain","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology University of Rajshahi  Rajshahi Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5262-4702","authenticated-orcid":false,"given":"Farhadul","family":"Islam","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology University of Rajshahi  Rajshahi Bangladesh"},{"name":"School of Medicine and Dentistry Griffith University  Gold Coast Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,28]]},"reference":[{"issue":"3","key":"e_1_2_12_2_1","first-page":"45","article-title":"Chemoprevention of Silymarin and Vitamin C on Isoniazid\u2010Induced Hepatotoxicity in Experimental Rat Model","volume":"2","author":"Ajiboye J. A.","year":"2015","journal-title":"Journal of Toxins"},{"issue":"6","key":"e_1_2_12_3_1","first-page":"407","article-title":"Restoration of Histoarchitecture in the Paracetamol\u2010Induced Liver Damaged Rat by Earthworm Extract, \n                     Lampito mauritii\n                   (Kinberg)","volume":"11","author":"Balamurugan M.","year":"2007","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules18066852"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0023-6438(95)80008-5"},{"issue":"3","key":"e_1_2_12_6_1","article-title":"Phenolic Compounds and Biological Activity of Selected Mentha Species","volume":"10","author":"\u0106avar Zeljkovi\u0107 S.","year":"2021","journal-title":"Plants (Basel, Switzerland)"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.3c00104"},{"issue":"12","key":"e_1_2_12_8_1","first-page":"4587","article-title":"Human Red Blood Cell Membrane Stability Testing for the Estimation of Anti\u2010Inflammatory Activity of Methanolic Extract of Millettia Pachycarpa Benth Leaves","volume":"4","author":"Chowdhury A.","year":"2013","journal-title":"International Journal of Pharmaceutical Sciences and Research"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(90)90463-U"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2015.07.005"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2023.11.053"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20040993"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(59)90090-6"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.1701"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2019.09.004"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0968-0004(90)90206-Q"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/02652048.2023.2209646"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23081848"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.4285"},{"issue":"1","key":"e_1_2_12_20_1","first-page":"151","article-title":"Hepatoprotective Effect of Plumbago zeylanica on Paracetamol Induced Liver Toxicity in Rats","volume":"3","author":"Kanchana N.","year":"2011","journal-title":"International Journal of Pharmacy and Pharmaceutical Sciences"},{"issue":"2","key":"e_1_2_12_21_1","first-page":"393","article-title":"An Evaluation of Hepatoprotective Activity of Aqueous and Ethanolic Extracts of Bacopa monnieri (L.) Against Paracetamol\u2010Induced Hepatotoxicity in Swiss Albino Mice","volume":"7","author":"Karim R.","year":"2020","journal-title":"European Journal of Biomedical and Pharmaceutical Sciences"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2011.01.017"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1051\/e3sconf\/202128204013"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12576-022-00845-1"},{"issue":"4","key":"e_1_2_12_25_1","first-page":"105","article-title":"Phytochemical and Pharmacological Potential of Mentha Piperita: A Review","volume":"3","author":"Kumar A.","year":"2014","journal-title":"Journal of Pharmacy and Phytochemistry"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2005.09.011"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1515\/labmed-2023-0023"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/1751-2980.13205"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10068-017-0217-9"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1122632"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.828565"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1556\/ABiol.61.2010.2.6"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/695678"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1177\/0023677215570992"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.21037\/jlpm-20-93"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12010-023-04392-2"},{"issue":"2","key":"e_1_2_12_37_1","first-page":"101","article-title":"Hepatoprotective Activity of Some Plants Extract Against Paracetamol Induced Hepatotoxicity in Rats","volume":"4","author":"Parmar S. R.","year":"2010","journal-title":"Journal of Herbal Medicine and Toxicology"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.4274\/tjps.galenos.2020.95870"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2023.155142"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(88)90499-6"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(98)00315-3"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.1991.tb03519.x"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.00509"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.3390\/plants7030070"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-019-05420-7"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27196728"},{"issue":"4","key":"e_1_2_12_47_1","first-page":"326","article-title":"In Vitro Anti\u2010Inflammatory Activity of \n                     Amaranthus caudatus\n                   L. Leaves","volume":"6","author":"Sen S.","year":"2015","journal-title":"Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2021.111932"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26041118"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1080\/03602532.2017.1354014"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40816-020-00207-7"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1080\/13880209.2020.1764058"}],"container-title":["Food Science &amp; Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/fsn3.71279","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/fsn3.71279","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/fsn3.71279","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T13:37:28Z","timestamp":1771421848000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/fsn3.71279"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,28]]},"references-count":51,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/fsn3.71279"],"URL":"https:\/\/doi.org\/10.1002\/fsn3.71279","archive":["Portico"],"relation":{},"ISSN":["2048-7177","2048-7177"],"issn-type":[{"value":"2048-7177","type":"print"},{"value":"2048-7177","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,28]]},"assertion":[{"value":"2025-06-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71279"}}