{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T14:12:41Z","timestamp":1771423961128,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T00:00:00Z","timestamp":1764979200000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100013221","name":"Razi Vaccine and Serum Research Institute","doi-asserted-by":"publisher","award":["3\u201035\u20101851\u2010114\u2010961101"],"award-info":[{"award-number":["3\u201035\u20101851\u2010114\u2010961101"]}],"id":[{"id":"10.13039\/501100013221","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The current study was conducted to investigate the antidiabetic and anti\u2010inflammatory effectiveness of encapsulated indigenous lactic acid bacteria originating from traditional Iranian cheese. Two out of 40 gram\u2010positive, catalase\u2010negative strains were selected and identified as\n                    <jats:italic>Lactiplantibacillus pentosus<\/jats:italic>\n                    and\n                    <jats:italic>Lactiplantibacillus plantarum<\/jats:italic>\n                    . Both strains exhibited strong acid (pH\u20092.5) and bile (0.3%) tolerance, with survival rates exceeding 64%. In\u00a0vitro hydrophobicity (&gt;\u200963%), autoaggregation (&gt;\u200966%), and coaggregation with\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Escherichia coli<\/jats:italic>\n                    <\/jats:styled-content>\n                    (over 51%) were observed. These strains also demonstrated the highest antimicrobial activity (inhibition zones up to 27\u2009mm) and were selected for in\u00a0vivo testing. Male Wistar rats (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200932) were randomly assigned to four groups: normal control, diabetic control (STZ, 35\u2009mg\/kg), normal + probiotics, and diabetic + probiotics (1\u2009\u00d7\u200910\n                    <jats:sup>9<\/jats:sup>\n                    \u2009CFU\/day, orally). At the end of 8\u2009weeks, diabetic rats receiving encapsulated probiotic strains showed significantly lower fasting blood glucose (200.8\u2009\u00b1\u20098.4 vs. 317.1\u2009\u00b1\u200910.7\u2009mg\/dL in diabetic controls,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01), higher serum insulin levels (12.3\u2009\u00b1\u20091.0 vs. 9.3\u2009\u00b1\u20090.9 \u03bcIU\/mL,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01), and better body weight retention (245 vs. 215\u2009g,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Proinflammatory cytokines IL\u20101\u03b2, IL\u20106, and TNF\u2010\u03b1 were significantly reduced in probiotic\u2010treated diabetic rats compared to untreated diabetic controls (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01). Probiotic delivery was well tolerated in normoglycemic rats, with no adverse effects reported. Overall, these findings support the potential of microencapsulated\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>L. pentosus<\/jats:italic>\n                    <\/jats:styled-content>\n                    D1 and\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>L. plantarum<\/jats:italic>\n                    <\/jats:styled-content>\n                    D2 as safe and effective adjuncts for managing type 2 diabetes by modulating glycemic and inflammatory responses.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.71295","type":"journal-article","created":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T12:24:27Z","timestamp":1765023867000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Encapsulated Indigenous Lactic Acid Bacteria Strains From Traditional Iranian Cheese Alleviate Hyperglycemia and Inflammation in Streptozotocin\u2010Induced Diabetic Rats"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3726-2920","authenticated-orcid":false,"given":"Yousef","family":"Nami","sequence":"first","affiliation":[{"name":"Department of Food Biotechnology, Branch for Northwest &amp; West Region, Agricultural Biotechnology Research Institute of Iran, Agricultural Research, Education and Extension Organization (AREEO)  Tabriz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Behnam","family":"Kafil","sequence":"additional","affiliation":[{"name":"Department of Livestock Bacterial Diseases Research Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO)  Karaj Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1102-3032","authenticated-orcid":false,"given":"Alireza","family":"Dehnad","sequence":"additional","affiliation":[{"name":"Department of Livestock Bacterial Diseases Research Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO)  Karaj Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02913315"},{"key":"e_1_2_10_3_1","unstructured":"Araya M. 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