{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T14:12:00Z","timestamp":1771423920330,"version":"3.50.1"},"reference-count":63,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T00:00:00Z","timestamp":1764806400000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Melia azedarach<\/jats:italic>\n                    <\/jats:styled-content>\n                    L., also known as the chinaberry tree, has long been used in traditional medicine to treat inflammatory conditions. In this study, we preliminarily investigated the anti\u2010inflammatory effect of 21\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2010methylmelianol (MMN), a tirucallane\u2010type triterpenoid isolated from\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>M. azedarach<\/jats:italic>\n                    <\/jats:styled-content>\n                    , in lipopolysaccharide (LPS)\u2010mediated RAW264.7 macrophages in\u00a0vitro and in a dextran sodium sulfate (DSS)\u2010stimulated ulcerative murine colitis model in\u00a0vivo. MMN reduced LPS\u2010stimulated nitric oxide production without inducing cytotoxicity. It significantly attenuated LPS\u2010induced protein expression of reactive oxygen species and effectively suppressed the production of pro\u2010inflammatory factors, including tumor necrosis factor\u2010alpha (TNF\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    ), interleukin (IL)\u20106, and IL\u20101\n                    <jats:italic>\u03b2<\/jats:italic>\n                    . In addition, mechanistic investigations showed that MMN inhibited signal transduction and activator of STAT3 phosphorylation and activation of nuclear factor\n                    <jats:italic>\u03ba<\/jats:italic>\n                    B (NF\u2010\n                    <jats:italic>\u03ba<\/jats:italic>\n                    B). In mice with DSS\u2010induced colitis, MMN attenuated DSS\u2010mediated pathological manifestations, including colon shortening, body weight loss, and histopathological alterations. Its in\u00a0vivo effects were associated with the regulation of pro\u2010 and anti\u2010inflammatory cytokine levels through suppression of the NF\u2010\n                    <jats:italic>\u03ba<\/jats:italic>\n                    B signaling cascade and downstream inflammatory pathways. Collectively, these findings provide compelling evidence of the anti\u2010inflammatory properties of MMN and highlight its therapeutic potential for the management of inflammatory disorders.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.71310","type":"journal-article","created":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T04:56:25Z","timestamp":1764910585000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Anti\u2010Inflammatory Effect of 21\n                    <i>\u03b1<\/i>\n                    \u2010Methylmelianol In\u00a0Vitro and In\u00a0Vivo via\n                    <scp>NF<\/scp>\n                    \u2010\n                    <i>\u03ba<\/i>\n                    <scp>B<\/scp>\n                    \/\n                    <scp>STAT<\/scp>\n                    Signaling Pathway Modulation"],"prefix":"10.1002","volume":"13","author":[{"given":"Fan","family":"Cao","sequence":"first","affiliation":[{"name":"Fujian Provincial Key Laboratory of Natural Medicine Pharmacology, Department of Pharmacy Fujian Medical University  Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Wu","sequence":"additional","affiliation":[{"name":"Fujian Provincial Key Laboratory of Natural Medicine Pharmacology, Department of Pharmacy Fujian Medical University  Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"He","sequence":"additional","affiliation":[{"name":"Fujian Provincial Key Laboratory of Natural Medicine Pharmacology, Department of Pharmacy Fujian Medical University  Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengxin","family":"Di","sequence":"additional","affiliation":[{"name":"Fujian Provincial Key Laboratory of Natural Medicine Pharmacology, Department of 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