{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T11:02:31Z","timestamp":1789988551886,"version":"4.0.1"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:00:00Z","timestamp":1768521600000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Type 2 diabetes mellitus (T2DM) is frequently associated with liver injury. This study examines the therapeutic potential of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Fucus vesiculosus<\/jats:italic>\n                    <\/jats:styled-content>\n                    \u2010derived low\u2010molecular\u2010weight fucoidan (Fuc\u2010S) in mitigating T2DM\u2010related hepatic damage. In STZ\/HFD\u2010induced diabetic mice, Fuc\u2010S treatment (100 or 200\u2009mg\/kg, 5\u2009weeks) significantly improved glucose tolerance, lipid metabolism, and liver function, while reducing hepatic steatosis and serum ALT\/AST levels. Fuc\u2010S enhanced hepatic antioxidant defenses, increasing SOD, CAT, and GSH\u2010Px activity while decreasing MDA levels. Gut microbiota analysis showed that Fuc\u2010S promoted the growth of beneficial bacteria (\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Bacteroides acidifaciens<\/jats:italic>\n                    <\/jats:styled-content>\n                    ) and elevated fecal short\u2010chain fatty acids (SCFAs), such as acetate, propionate, and butyrate. Furthermore, Fuc\u2010S reinforced intestinal barrier integrity by upregulating tight junction proteins (ZO\u20101 and occludin). These results indicate that Fuc\u2010S alleviates T2DM\u2010induced liver injury by modulating the gut microbiota\u2010SCFA\u2010liver axis, thereby reducing oxidative stress and inflammation. The study suggests Fuc\u2010S as a promising dietary intervention for T2DM, acting through multi\u2010target microbiota\u2010metabolite interactions.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.71321","type":"journal-article","created":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T09:00:46Z","timestamp":1768554046000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Fuc\u2010S, a New Degraded Polysaccharide From Fucoidan, Alleviates Type 2 Diabetes\u2010Associated Liver Injury Through Modulating Gut Microbiota"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2146-5854","authenticated-orcid":false,"given":"Bin","family":"Du","sequence":"first","affiliation":[{"name":"Hebei Key Laboratory of Natural Products Activity Components and Function Hebei Normal University of Science and Technology  Qinhuangdao 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