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Broilers were randomly divided into three groups: (1) Control (23\u00b0C\u2009\u00b1\u20092\u00b0C), (2) Heat stress (HS, 35\u00b0C\u2009\u00b1\u20092\u00b0C, 8\u2009h\/day), and (3) Resveratrol (HS\u2009+\u2009resveratrol) group. Resveratrol supplementation (400\u2009mg\/kg diet) commenced 48\u2009h prior to HS and continued throughout the experimental period. The results showed that resveratrol improved growth performance with a higher average daily gain (ADG) and lower feed conversion ratio (FCR), and increased liver weight and index along with reduced inflammatory cell infiltration in broilers. In addition, resveratrol upregulated the autophagy\u2010related genes and protein levels in the liver. Moreover, resveratrol obviously down\u2010regulated the protein and mRNA levels of the NOD\u2010like receptor protein 3 (NLRP3) inflammasome. In conclusion, resveratrol mitigated heat stress\u2010induced liver injury by modulating autophagy and down\u2010regulating NLRP3 inflammasome activation.<\/jats:p>","DOI":"10.1002\/fsn3.71326","type":"journal-article","created":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T11:42:47Z","timestamp":1764934967000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Protective Effects of Resveratrol on Heat Stress\u2010Induced Liver Dysfunction in Broilers Through Modulating Autophagy and\n                    <scp>NLRP3<\/scp>\n                    Inflammasome"],"prefix":"10.1002","volume":"13","author":[{"given":"Kang\u2010Ning","family":"Ding","sequence":"first","affiliation":[{"name":"School of Animal Science and Technology Foshan University  Foshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi\u2010Hao","family":"Li","sequence":"additional","affiliation":[{"name":"School of Animal Science and Technology Foshan University  Foshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia\u2010Ci","family":"Cai","sequence":"additional","affiliation":[{"name":"School of Animal Science and Technology Foshan University  Foshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui\u2010Lin","family":"Li","sequence":"additional","affiliation":[{"name":"School of Animal Science and Technology Foshan University  Foshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Animal Science and Technology Foshan University  Foshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya\u2010Qiong","family":"Ye","sequence":"additional","affiliation":[{"name":"School of Animal Science and Technology Foshan University  Foshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6790-3480","authenticated-orcid":false,"given":"Lu\u2010Ping","family":"Tang","sequence":"additional","affiliation":[{"name":"School of Animal Science and Technology Foshan University  Foshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,5]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtherbio.2021.103019"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10010035"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psj.2021.101217"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.859231"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11481\u2010024\u201010101\u20105"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2022.950174"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40104\u2010022\u201000822\u2010z"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtherbio.2022.103332"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psj.2022.101794"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118833"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011\u2010019\u201001841\u20100"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adj8027"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25084537"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022\u20100302(03)74040\u20105"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells8020141"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psj.2022.102085"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612826666200417165801"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani10081266"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.2141\/jpsa.0200003"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2017.1378838"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psj.2023.102968"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09663"}],"container-title":["Food Science &amp; 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