{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T04:03:15Z","timestamp":1792641795739,"version":"4.5.0"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study investigated the anti\u2010aging effects of algal Omega3\u2010DHA in senescence\u2010accelerated mice (SAM). Male and female SAMP8 mice (3\u2009months old) were divided into a control group and four experimental groups (1\u00d7 or 2\u00d7 algal Omega3\u2010DHA, with\/without phospholipids). The mice were orally administered test samples dissolved in corn oil daily for 13\u2009weeks. Aging scores were significantly lower in male mice across all experimental groups and in female mice in the phosphatidylcholine (PC) and phosphatidylserine (PS) (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05) groups. Learning and memory improved significantly in all the experimental groups (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Brain biomarkers of aging, including 8\u2010hydroxy\u20102\u2032\u2010deoxyguanosine (8\u2010OHdG), thiobarbituric acid\u2010reactive substances (TBARS), protein carbonyl content, and \u03b2\u2010amyloid (A\u03b2) protein, were significantly reduced, while liver antioxidant enzyme activities, including superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx), were increased in the PC and PS groups (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Additionally, survival times were extended in both male and female mice compared to controls. No adverse effects were observed in terms of body weight or activity level. In summary, algal Omega3\u2010DHA supplementation improved cognitive performance, enhanced antioxidant defenses, reduced aging markers, and delayed aging in SAM mice, highlighting its potential as a promising anti\u2010aging strategy.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.71353","type":"journal-article","created":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T06:18:07Z","timestamp":1769840287000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Potential Anti\u2010Aging Effects of a Dietary Supplement From the Algal\u2010Derived Omega\u20103\n                    <scp>DHA<\/scp>\n                    in Aged\n                    <scp>SAMP<\/scp>\n                    8 Mice"],"prefix":"10.1002","volume":"14","author":[{"given":"Ming\u2010Yu","family":"Chou","sequence":"first","affiliation":[{"name":"Wenzhou Medical University Big One Health Development Research Institute  Wenzhou City Zhejiang Province China"},{"name":"International Aging Industry Research &amp; Development Center (AIC), Providence University  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I\u2010Hung","family":"Lin","sequence":"additional","affiliation":[{"name":"Y.C.C. Parts MFG Co., Ltd.  Lukang Township Changhua County Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia\u2010Jung","family":"Chen","sequence":"additional","affiliation":[{"name":"Y.C.C. Parts MFG Co., Ltd.  Lukang Township Changhua County Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting\u2010Jian","family":"Guo","sequence":"additional","affiliation":[{"name":"Wenzhou Medical University Big One Health Development Research Institute  Wenzhou City Zhejiang Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Che\u2010An","family":"Lin","sequence":"additional","affiliation":[{"name":"Wenzhou Medical University Big One Health Development Research Institute  Wenzhou City Zhejiang Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dao\u2010Na","family":"Yang","sequence":"additional","affiliation":[{"name":"Wenzhou Medical University Big One Health Development Research Institute  Wenzhou City Zhejiang Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9686-8434","authenticated-orcid":false,"given":"Po\u2010Hsien","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Food and Nutrition Providence University  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Chen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Food and Nutrition Providence University  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei\u2010Due","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Surgery, Department of Clinical Nutrition China Medical University Hospital  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chieh\u2010Chang","family":"Tien","sequence":"additional","affiliation":[{"name":"Y.C.C. 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