{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:08:08Z","timestamp":1790690888961,"version":"4.1.0"},"reference-count":194,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp;amp; Nutrition"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Human health and ever\u2010increasing disease burden demand the inclusion of traditional medicines in modern healthcare sectors. Phytochemicals extracted from medicinal plants can be utilized to prepare nutritious and quality food products that could offer nutritional and curative benefits. This review highlights the nutritional, phytochemical, and therapeutic profile of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Salvia coccinea<\/jats:italic>\n                    <\/jats:styled-content>\n                    and its bioactive compound i.e., apigenin.\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Salvia coccinea<\/jats:italic>\n                    <\/jats:styled-content>\n                    , the urban green, scarlet, lance\u2010shaped flower, is cultivated in warm climatic conditions from summer to autumn. The micronutrient\u2010dense (sodium, calcium, potassium, zinc, nitrogen, and copper) leaves can prevent micronutrient\u2010deficiency disorders among consumers. Furthermore, apigenin along with other bioactive constituents e.g., luteolin, flavonoids, and phenolic acids offer strong antioxidants, anticancer, anti\u2010inflammatory, antidiabetic, antimicrobial, and anti\u2010cardiovascular properties. The free radical scavenging potential of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Salvia coccinea<\/jats:italic>\n                    <\/jats:styled-content>\n                    and apigenin is responsible for reduced oxidative stress and tumor cell metastasis modulated through PARP\u2010cleavage, caspase\u20103, ERK, CDK\u20101, JAK2\/STAT3, Bax\/Bcl\u20102, AMPK, and Wnt\/\u03b2\u2010catenin pathways. They attenuate inflammation\u2010induced disorders such as cardiovascular and neurological disorders via down\u2010regulating pro\u2010inflammatory cytokines (IL\u20106, CRP, COX\u20102, LPO, TGF\u2010\u03b21, NF\u2010\u03baB, and TNF\u2010\u03b1), and pathways (IRAK4, MAPK, JAK\/STAT3, TLR4, and ERK). The antimicrobial properties against multiple bacterial, viral, and fungal strains make them effective candidates for alleviating microbial disorders. Furthermore, apigenin and\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Salvia coccinea<\/jats:italic>\n                    <\/jats:styled-content>\n                    promote hypoglycemic effect by attenuating \u03b1\u2010amylase activity, cholesterol levels, insulin resistance, DRP1 expression by improving GLUT4, GSK\u20103\u03b2, AMPK\/PI3K\/Nrf2, and Akt pathways. Moreover,\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Salvia coccinea<\/jats:italic>\n                    <\/jats:styled-content>\n                    regulates wound healing after infection, injury, or surgery, in addition to improving agricultural productivity by reducing rodent attacks.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.71354","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T09:16:00Z","timestamp":1770110160000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>\n                      <i>Salvia coccinea<\/i>\n                    <\/scp>\n                    and Apigenin: A Natural Treasure of Lamiaceae in Pharmacological Innovation"],"prefix":"10.1002","volume":"14","author":[{"given":"Muhammad Usman","family":"Khalid","sequence":"first","affiliation":[{"name":"Faculty of Food Science and Nutrition Bahauddin Zakariya University  Multan Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2852-7555","authenticated-orcid":false,"given":"Muhammad Tauseef","family":"Sultan","sequence":"additional","affiliation":[{"name":"Faculty of Food Science and Nutrition Bahauddin Zakariya University  Multan Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Maaz","sequence":"additional","affiliation":[{"name":"Faculty of Food Science and Nutrition Bahauddin Zakariya University  Multan Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shehnshah","family":"Zafar","sequence":"additional","affiliation":[{"name":"Faculty of Food Science and Nutrition Bahauddin Zakariya University  Multan Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anum","family":"Shoukat","sequence":"additional","affiliation":[{"name":"Faculty of Food Science and Nutrition Bahauddin Zakariya University  Multan Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nudrat","family":"Khursheed","sequence":"additional","affiliation":[{"name":"Faculty of Food Science and Nutrition Bahauddin Zakariya University  Multan Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6587-9843","authenticated-orcid":false,"given":"Matteo","family":"Bordiga","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences Universit\u00e0 Degli Studi del Piemonte Orientale \u201cA. 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